A5034214837- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Electrospun Nanofibers in Biomedical Applications
- Immune Cell Function and Interaction
- Graphene and Nanomaterials Applications
- Gut microbiota and health
- Supramolecular Self-Assembly in Materials
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Inhalation and Respiratory Drug Delivery
- Analytical Chemistry and Sensors
- CAR-T cell therapy research
- Advanced Causal Inference Techniques
- Spinal Cord Injury Research
- Advanced Nanomaterials in Catalysis
- Polymer Surface Interaction Studies
- Nerve injury and regeneration
- Hydrogels: synthesis, properties, applications
- Intraperitoneal and Appendiceal Malignancies
Soochow University
2021-2025
Xiamen University
2023-2025
Collaborative Innovation Center of Chemistry for Energy Materials
2024-2025
Tan Kah Kee Innovation Laboratory
2023-2024
University of Science and Technology of China
2018-2021
Changchun Institute of Applied Chemistry
2015-2021
Chinese Academy of Sciences
2015-2021
University of Chinese Academy of Sciences
2015-2017
Radiotherapy (RT), as one of the main methods in clinical treatment various malignant tumors, would induce systemic immunotherapeutic effects by triggering immunogenic cell death (ICD) cancer cells. However, antitumor immune responses produced RT-induced ICD alone usually are not robust enough to eliminate distant tumors and thus ineffective against metastases. Herein, a biomimetic mineralization method for facile synthesis MnO2 nanoparticles with high anti-programmed ligand 1 (αPDL1)...
For idiopathic pulmonary fibrosis (IPF), interleukin 11 (IL-11) is a pivotal cytokine that stimulates the transformation of fibroblasts into myofibroblasts, thus accelerating progression fibrosis. Here, we develop an innovative inhalable small interfering RNA (siRNA) delivery system termed PEI-GBZA, which demonstrates impressive efficiency in loading siIL-11 targeting IL-11 (siIL-11) and substantially suppresses differentiation myofibroblasts epithelial-mesenchymal transition (EMT), reduces...
High transfection efficiency and low cytotoxicity are the two key factors to be considered in design of gene carriers. Herein, a novel versatile carrier (PLL-RT) was prepared by introducing "molecular string" RT (i.e., p-toluylsulfonyl arginine) onto polylysine backbone. The introduction string contributed formation multiple interactions between polycationic carriers cell membrane or DNA, as well adopting α-helix conformation, all which would beneficial enhance transfection. In addition,...
Immunotherapy holds great promise for patients undergoing tumor treatment. However, the clinical effect of immunotherapy is limited because immunogenicity and its immunosuppressive microenvironment. Herein, metal–organic framework (MIL-100) loaded with chemotherapeutic agent mitoxantrone (MTO) was combined photothermal-chemotherapy enhancing immunogenic cell death. MIL-100 MTO hyaluronic acid as nanoparticles (MMH NPs) yielded an NP two therapeutic properties (photothermal chemotherapy) dual...
Tumor nanovaccines have potential applications in the prevention and treatment of malignant tumors. However, it remains a longstanding challenge exploiting efficient nanocarriers for inducing potent specifically cellular immune responses. Toward this objective, we herein explore an intensive tumor immunotherapeutic strategy by combining mannosylated gene regulated PD-L1 blockade stimulation killing activity. Here, fabricate mannose modified PLL-RT (Man-PLL-RT) mediated with dendritic cells...
Abstract Immunotherapy has become a powerful cancer treatment, but only small fraction of patients have achieved durable benefits due to the immune escape mechanism. In this study, epigenetic regulation is combined with gene therapy-mediated checkpoint blockade relieve PPD (i.e., m P EG-b-PLG/ EI-RT3/ D NA) developed mediate plasmid-encoding shPD-L1 delivery by introducing multiple interactions electrostatic, hydrogen bonding, and hydrophobic interactions) polyproline II (PPII)-helix...
Clinical evidence indicates that tumor-colonizing bacteria can be closely related to the tumor development and therapeutic responses. Selectively eliminating within tumors may an attractive approach enhance cancer treatment without additional side effects. Herein, it is found that, owing high affinity between membrane protein Fap-2 on Fusobacterium nucleatum d-galactose-β (1-3)-N-acetyl-d-galactosamine (Gal-GalNAc) overexpressed colorectal cells, F. colonize in tumors, as evidenced by both...
Oral administration of protein drugs has always been challenging owing to various intestinal barriers. Herein, we developed an efficient oral delivery strategy by using in situ polymerization zwitterions encapsulate proteins, which were then loaded into enteric coated capsules for feeding. After such capsules, the coating would be degraded once capsule enters intestine, releasing polyzwitterion/protein nanocomplexes. With help polyzwitterion modification, nanocomplexes able pass through...
Abstract Spinal cord injury (SCI) is a severe neurological disorder characterized by significant disability and limited treatment options. Mitigating the secondary inflammatory response following initial primary focus of current research in SCI. CCL2 (C─C motif chemokine ligand 2) serves as regulator responsible for chemotaxis majority peripheral immune cells, blocking CCL2‐CCR2 receptor type axis has shown considerable therapeutic potential diseases, including In this study, it presents...
The aberrant tumor microenvironment (TME), especially immature and leaky vessels, prevents the penetration accumulation of chemotherapeutics results in failure chemotherapy to treat gynecologic cancer. Herein, dexamethasone (Dex), a glucocorticoid steroid used moderate extracellular matrix normalize was enclosed within biocompatible material known as poly(lactic-co-glycolic acid) (PLGA), obtained Dex@PLGA further coated with mouse cervical cancer cell membrane (CM). formulated Dex@PLGA-CM...
Lithocholic acid (LCA) is accumulated in mammals during calorie restriction and it can activate AMP-activated protein kinase (AMPK) to slow down ageing1. However, the molecular details of how LCA activates AMPK induces these biological effects are unclear. Here we show that enhances activity sirtuins deacetylate subsequently inhibit vacuolar H+-ATPase (v-ATPase), which leads activation through lysosomal glucose-sensing pathway. Proteomics analyses proteins co-immunoprecipitated with sirtuin...
Obesity usually induces systemic metabolic disturbances, including in the tumor microenvironment (TME). This is because adaptive metabolism related to obesity TME with a low level of prolyl hydroxylase-3 (PHD3) depletes major fatty acid fuels CD8+ T cells and leads poor infiltration unsatisfactory function cells. Herein, we discovered that could aggravate immunosuppressive weaken cell-mediated cell killing. We have thus developed gene therapy relieve obesity-related promote cancer...
Osteosarcoma is an aggressive malignant tumor that primarily develops in children and adolescents. The conventional treatments for osteosarcoma often exert negative effects on normal cells, chemotherapeutic drugs, such as platinum, can lead to multidrug resistance cells. Herein, this work reports a new bioinspired tumor-targeting enzyme-activatable cell-material interface system based DDDEEK-pY-phenylboronic acid (SAP-pY-PBA) conjugates. Using tandem-activation system, selectively regulates...
Constructing an efficient in vivo gene delivery system has always been extremely challenging. Herein, a highly H2O2-responsive polycationic is developed for the first time. The vector PLL-RT (i.e., polylysine grafted with p-tosyl-l-arginine) used to mediate plasmid DNA (pDNA) delivery, and thioketal dipropanedioic acid-modified dextran (TDPAD) as shielding effectively coating vector/pDNA polyplexes. constructed exhibits prolonged circulatory half-life accelerates accumulation of vector/DNA...
Vaccine technology is effective in preventing and treating diseases, including cancers viruses. The efficiency of vaccines can be improved by increasing the dosage frequency injections, but it would bring an extra burden to people. Therefore, necessary develop vaccine-boosting techniques with negligible side effects. Herein, we reported a cupping-inspired noninvasive suction therapy that could enhance efficacy cancer/SARS-CoV-2 nanovaccines. Negative pressure caused mechanical immunogenic...