A5054982722- Neuroinflammation and Neurodegeneration Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- RNA regulation and disease
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- DNA and Nucleic Acid Chemistry
- Cyclopropane Reaction Mechanisms
- Advanced Photocatalysis Techniques
- Gut microbiota and health
- Advanced Thermoelectric Materials and Devices
- Fluorine in Organic Chemistry
- Laser Design and Applications
- Molecular Biology Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- RNA Research and Splicing
- Cardiac electrophysiology and arrhythmias
- Epigenetics and DNA Methylation
- Spectroscopy and Laser Applications
- Covalent Organic Framework Applications
South China Agricultural University
2024-2025
Lanzhou University
2024
Affiliated Hospital of Southwest Medical University
2018-2024
Southwest Medical University
2021-2024
Nanjing Normal University
2021-2023
University of Wisconsin–Madison
2021
Nanyang Technological University
2019-2020
Minneapolis Heart Institute Foundation
2018
University of Minnesota
2018
Xiamen University
2015-2017
Hypoxia of solid tumor compromises the therapeutic outcome photodynamic therapy (PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting ruthenium as active catalytic site anchored in metal-organic framework Mn3[Co(CN)6]2 with encapsulated chlorin e6 (Ce6), which serves catalase-like nanozyme for generation....
Covalent organic frameworks (COFs) are excellent platforms with tailored functionalities in photocatalysis. There still challenges increasing the photochemical performance of COFs. Therefore, we designed and prepared a series COFs for photocatalytic hydrogen generation. Varying different ratios β-ketoenamine to imine moieties linkages could differ ordered structure, visible light harvesting, bandgap. Overall, β-ketoenamine-linked exhibited much better activity than those having both on...
Abstract Nanomaterials with enzyme‐mimicking activity (nanozymes) show potential for therapeutic interventions. However, it remains a formidable challenge to selectively kill tumor cells through enzymatic reactions, while leaving normal unharmed. Herein, we present new strategy based on single‐site cascade reaction tumor‐specific therapy that avoids off‐target toxicity tissues. A copper hexacyanoferrate (Cu‐HCF) nanozyme active exhibited within the microenvironment: Tumor‐specific...
Covalent organic frameworks (COFs) are an emerging class of crystalline porous polymers with tailor-made structures and functionalities. To facilitate their utilization for advanced applications, it is crucial to develop a systematic approach control the properties COFs, including crystallinity, stability, However, such integrated design challenging achieve. Herein, we report supramolecular strategy-based linkage engineering fabricate versatile 2D hydrazone-linked COF platform coordination...
Intracellular antioxidants such as glutathione (GSH) play a critical role in protecting malignant tumor cells from apoptosis induced by reactive oxygen species (ROS) and mechanisms of multidrug radiation resistance. Herein, we rationally design two multicomponent self-assembled photodynamic therapy (PDT) nanoagents, that is, Glup-MFi-c Glud-MFo-c, which consist respective GSH-passivation GSH-depletion linkers metal–organic frameworks encapsulated with photosensitizers for deeply...
Leukoaraiosis (LA) refers to white matter hyperintensities or lesions (WMLs) on magnetic resonance imaging (MRI) scans of the brain; this disease is associated with an increased risk stroke, dementia, and cognitive decline. The aims study are assess incidence LA its factors in a Chinese population. A hospital-based cross-sectional was conducted that included 4683 patients who were 40 years older. Data collected age, sex, hypertension, diabetes, smoking, drinking, homocysteine (HCY),...
The aim of this study was to identify mRNA targets dysregulated miRNAs through the integrated analysis miRNA and expression profiling in men with normal versus impaired spermatogenesis. mRNAs testicular tissues obtained from males non-obstructive azoospermia (NOA, n = 4) or obstructive (OA, 3) spermatogenesis analyzed using microarray technology. Some most interesting results were validated by real time PCR samples same cohort. Ninety-three 4172 differentially expressed NOA normozoospermic...
Abstract Nanomaterials with enzyme‐mimicking activity (nanozymes) show potential for therapeutic interventions. However, it remains a formidable challenge to selectively kill tumor cells through enzymatic reactions, while leaving normal unharmed. Herein, we present new strategy based on single‐site cascade reaction tumor‐specific therapy that avoids off‐target toxicity tissues. A copper hexacyanoferrate (Cu‐HCF) nanozyme active exhibited within the microenvironment: Tumor‐specific...
We herein report the development of a novel Pd/Ni dual-catalyzed ring-opening functionalization
Abstract Neuroinflammation has been reported to be associated with white matter injury (WMI) after subarachnoid hemorrhage (SAH). As the main resident immune cells of brain, microglia can activated into proinflammatory and anti‐inflammatory phenotypes. Toll‐like receptor 4 (TLR4), expressed on surface microglia, plays a key role in microglial inflammation. However, relationship between TLR4, polarization, WMI following SAH remains unclear. In this study, total 121 male adult C57BL/6...
We herein report the development of a novel Pd-catalyzed dearomative functionalization pyrroles with gem-difluorinated cyclopropanes (gem-F2CPs). This dearomative/ring-opening strategy streamlines diversity-oriented synthesis (DOS) α-quaternary 2-fluoroallylic 2H-pyrroles broad scope and excellent functional group tolerance, which enables efficient late-stage transformation complex bioactive molecule-derived gem-F2CPs. Derivation resulting fluoroallylic to different synthetically useful...
Hereditary hemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is an autosomal dominant disorder characterized by arteriovenous malformations (AVMs) affecting multiple organs. This case report presents a rare of 62-year-old female with cerebral infarctions following fall, subsequently diagnosed HHT. Clinical features included recurrent epistaxis, tongue telangiectasias, and pulmonary AVMs (PAVMs). Genetic testing identified novel duplication mutation in the ENG gene,...
Neuroinflammation can be caused by various factors in early brain injury after subarachnoid hemorrhage (SAH). One of the most important features this process is M1 microglial activation. In turn, TLR4/NF-κB pathway plays an essential role activating phenotypic microglia. Biglycan, a small leucine-rich proteoglycan, functions as endogenous ligand TLR4 and TLR2 macrophages. However, underlying mechanisms associated with activation stroke pathogenesis are poorly understood. Here, we aimed to...
The thermoelectric generator (TEG) can convert heat to electricity and is widely used. To overcome the limitation for low efficiency of materials, optimizing performance TEG in given system necessary. This study proposes a method match individual components environment based on two boundary conditions—temperature flux. With this method, geometrical parameters be determined optimize by varying temperature as an independent variable. Using undersea Radioisotope (u‐RTG) optimized. exhibits...
After ischemic stroke (IS), secondary injury is intimately linked to endoplasmic reticulum (ER) stress and body-brain crosstalk. Nonetheless, the underlying mechanism systemic immune disorder mediated ER in human IS remains unknown. In this study, 32 candidate stress-related genes (ERSRGs) were identified by overlapping MSigDB pathway DEGs. Three Key ERSRGs (ATF6, DDIT3 ERP29) using LASSO, random forest, SVM-RFE. patients with different profile clustered into two groups consensus clustering...
COG1410, a mimetic peptide derived from the apolipoprotein E (apoE) receptor binding region, exerts positive effect on neurological deficits in early brain injury (EBI) after experimental subarachnoid hemorrhage (SAH). Currently neuroprotective of COG1410 includes inhibiting BBB disruption, reducing neuronal apoptosis and neuroinflammation. However, mechanism to subcellular organelles disorder have not been fully investigated. As main pathway for recycling long-lived proteins damaged...
Abstract Hepatocellular carcinoma (HCC) is a life‐threatening disease for which there no cure. Traditional Chinese medicine treasure trove of Medicinals that has been used thousands years. In China, the traditional herb pair, Curcumae Rhizoma and Sparganii (CR‐SR) represent classic herbal combination treatment HCC. However, drug targets pharmacological mechanism action CR‐SR in HCC are unclear. To address this, we screened active components from Medicine Systems Pharmacology (TCMSP) database...
Objectives The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, European populations. This study aims to assess association of variant with PD leucoaraiosis (LA) Han Chinese population. Setting population-based was conducted China by Xiamen University its affiliated hospital. Participants 308 patients LA, 342 198...
Glioblastoma multiforme (GBM) is the most malignant primary tumour in central nervous system, but molecular mechanisms underlying its pathogenesis remain unclear. In this study, data set GSE50161 was used to construct a co‐expression network for weighted gene analysis. Two modules (dubbed brown and turquoise) were found have strongest correlation with GBM. Functional enrichment analysis indicated that module involved cell cycle, DNA replication, pyrimidine metabolism. The turquoise primarily...
Arterial hypertension is considered the most prevalent risk factor for stroke. Both pathophysiologic and clinical data previously acquired suggest a strong correlation between hemodynamic nature of arterial an increase in ischemic insult to tissues. However, knowledge specific molecular interactions stroke (IS) limited. In this study, we performed systematic bioinformatics analysis stroke-prone spontaneous hypertensive brain tissue samples rats (GSE41452), middle cerebral artery occlusion...
A modified molecular beacon that possesses a stem-hairpin structure as seen in conventional beacons and can be cleaved during PCR is designed, it specifically recognize the presence of target was obviously more sensitive than beacons.