A5101625926- Cancer, Hypoxia, and Metabolism
- Mosquito-borne diseases and control
- Sperm and Testicular Function
- Aquaculture disease management and microbiota
- Reproductive Biology and Fertility
- Cancer Genomics and Diagnostics
- Environmental Toxicology and Ecotoxicology
- Viral Infections and Vectors
- Ferroptosis and cancer prognosis
- Invertebrate Immune Response Mechanisms
- Viral gastroenteritis research and epidemiology
- Heavy Metal Exposure and Toxicity
- Hormonal and reproductive studies
- Insect symbiosis and bacterial influences
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pregnancy and preeclampsia studies
- Gallbladder and Bile Duct Disorders
- Microbial Inactivation Methods
- Fecal contamination and water quality
- Dengue and Mosquito Control Research
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Pregnancy and Medication Impact
- 14-3-3 protein interactions
Institute of Microbiology
2020-2025
Guizhou University
2025
Zhuhai People's Hospital
2024
Shanghai Jiao Tong University
2019-2024
Ruijin Hospital
2019-2024
Guangdong Ocean University
2023-2024
Southwest Medical University
2021-2023
Zhejiang University of Technology
2022-2023
Affiliated Hospital of Southwest Medical University
2022
École Polytechnique Fédérale de Lausanne
2022
Prostaglandin E2 (PGE2) plays an important role in vascular homeostasis. Its receptor, E-prostanoid receptor 4 (EP4) is essential for physiological remodeling of the ductus arteriosus (DA). However, EP4 pathological remains largely unknown. We found that chronic angiotensin II (AngII) infusion mice with smooth muscle cell (VSMC)-specific gene knockout (VSMC-EP4-/-) frequently developed aortic dissection (AD) severe elastic fiber degradation and VSMC dedifferentiation. AngII-infused...
Abstract A positive thermoresponsive hydrogel composed of poly(acrylic acid)‐ graft ‐β‐cyclodextrin (PAAc‐ g ‐β‐CD) and polyacrylamide (PAAm) was synthesized with the sequential interpenetrating polymer network (IPN) method for purpose improving its loading release drugs. The structure properties PAAc‐ ‐β‐CD/PAAm (IPN hydrogel) were characterized Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), swelling measurements. FTIR studies showed that IPN...
Abstract Spermiogenesis is considered to be crucial for the production of haploid spermatozoa with normal morphology, structure and function, but mechanisms underlying this process remain largely unclear. Here, we demonstrate that SPEM family member 2 ( Spem2 ), as a novel testis-enriched gene, essential spermiogenesis male fertility. predominantly expressed in germ cells highly conserved across mammals. Mice deficient develop infertility associated impairment. Specifically, insufficient...
Accelerating urbanization development has a great impact on water environment with altered hydrological cycle process, deteriorating quality and redistributed quantity. In addition, urban river-lake networks have emerged as blend of natural engineered under artificial transformation. However, exchange relationships pollution patterns in such are complicated poorly understood due to various disturbances from both nature social activities. This study investigated chemistry stable isotopic...
Plants release a variety of defensive volatiles in response to biotic stress. The present study examined interactions between Colletotrichum fructicola and the defense induced by this fungal species tea cultivar "Qiancha No. 1". Analysis emitted from C. fructicola-infected leaves 1" revealed that four showed relative content increase more than 2%. Fungicidal activity assays demonstrated decanal exhibited strongest antifungal among volatiles. Further physiological experiments mechanism was...
Waterborne enteric viruses in lakes, especially at recreational water sites, may have a negative impact on human health. However, their fate and transport lakes are poorly understood. In this study, we propose coupled quality quantitative microbial risk assessment (QMRA) model to study the transport, infection of four common waterborne (adenovirus, enterovirus, norovirus rotavirus), using Lake Geneva as site. The measured virus load raw sewage entering lake was used source term simulations...
Background Obstructive sleep apnea (OSA) is a common and severe social problem. Erectile dysfunction (ED) an important health concern. The prevalence of OSA with ED increasing, which significantly affects the quality life work efficiency patients. However, mechanism underlying comorbidity these two diseases remains unclear. Objectives (1) Investigate ED; (2) analyze correlation between (3) explore treatment response to possible uvulapalatopharyngoplasty (UPPP) in patients ED. This study aims...
As more data on virus concentrations in influent water from wastewater treatment plants (WWTPs) becomes available, establishing best practices for measurements, monitoring, and statistical modelling can improve the understanding of concentration distributions wastewater. To support this, we assessed temporal variability norovirus, adenovirus, enterovirus, rotavirus across multiple WWTPs Switzerland, USA, Japan. Our findings demonstrate that lognormal distribution accurately predicts...
Testis-specific genes are prone to affect spermatogenesis or sperm fertility, and thus may play pivotal roles in male reproduction. However, whether a gene really affects reproduction vivo needs be confirmed using knock-out (KO) model, 'gold standard' method. Increasing studies have found that some of the evolutionarily conserved testis-enriched not essential for fertility. In this study, we report 1700121C10Rik, previously uncharacterized gene, is specifically expressed testis produces two...
A disintegrin and metalloproteinase 3 (ADAM3) is a sperm membrane protein critical for migration from the uterus into oviduct sperm-egg binding in mice. Disruption of PRSS37 results male infertility concurrent with absence mature ADAM3 cauda epididymal sperm. However, how modulates maturation remains largely unclear. Here, we determine interactome by GFP immunoprecipitation coupled mass spectrometry PRSS37-EGFP knock-in Three molecular chaperones (CLGN, CALR3 PDILT) three ADAM proteins...
In the present study, we investigated potential of nitrite exposure to induce infertility in mice. Adult female C57BL/6J mice were randomly divided into control and groups. Subsequently, rate mouse was calculated, pathological changes ovarian tissues examined using hematoxylin eosin staining. addition, TUNEL staining, immunofluorescent labeling, western blotting performed assess cell apoptosis oxidative stress response from various We observed that could (p<0.05) High-dose caused a...
Abstract Background Drug resistance and metastasis involving hypoxic tumor environments persistent stem cell populations are detrimental to the survival of patients with non-small lung carcinoma (NSCLC). Tie1 is upregulated in hypoxia believed counteract effectiveness platinum agents by promoting stemness properties cells. We have investigated association HIF-1α cisplatin NSCLC lines. Methods The expression a pulmonary microvascular endothelial line (HPMEC) lines was detected using qRT-PCR...
Abstract Serine proteases (PRSS) constitute nearly one-third of all proteases, and many them have been identified to be testis-specific play significant roles during sperm development male reproduction. PRSS54 is one the PRSS in mouse human but its physiological function remains largely unclear. In present study, we demonstrate detail that exists not only testis also mature sperm, exhibiting a change protein size from 50 kDa 42 sperm. Loss mice results subfertility, acrosome deformation,...
Abstract Background Serum CGRP has been found to increase during migraine attack. However, whether can identify MA with PFO subtypes in remains unknown. This study aimed investigate the differential expression of calcitonin gene-related peptide (CGRP) between (MA) patients and without patent foramen ovale (PFO), evaluate predictive value for PFO. Methods A total 153 MA, 51 102 without. Venous blood was drawn HIT-6 score calculated onset routine, inflammatory indexes serum were detected. The...
Irreversible electroporation has been proved as a feasible and safe method against tumor in liver. However, few studies focused on tumors adjacent to perihepatic important structure like vessels, biliary system gall bladder. These structures limit the effectiveness of conventional treatments. The aim this article is analyze clinical outcomes patients with hepatic at special sites who received IRE treatment provide reliable evidence for broadening scope IRE's application.