A5100332286- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Hippo pathway signaling and YAP/TAZ
- Neurogenesis and neuroplasticity mechanisms
- RNA modifications and cancer
- Nerve injury and regeneration
- RNA Research and Splicing
- Spine and Intervertebral Disc Pathology
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Cancer-related Molecular Pathways
- Pain Mechanisms and Treatments
- RNA regulation and disease
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
- Osteoarthritis Treatment and Mechanisms
- Oral microbiology and periodontitis research
- RNA Interference and Gene Delivery
- Lipid metabolism and biosynthesis
- Nuclear Receptors and Signaling
- Immune Cell Function and Interaction
Soochow University
2015-2025
First Affiliated Hospital of Zhengzhou University
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
The First People's Hospital of Changzhou
2010-2024
State Key Laboratory of Chemical Engineering
2024
State Grid Corporation of China (China)
2024
Nanjing Medical University
2024
East China University of Science and Technology
2024
Qilu Hospital of Shandong University
2023
Fudan University
2020-2022
Yes-associated protein 1 (YAP1) exerts significant effects in various malignancies. However, the oncogenic role of YAP1 remains controversial, and mechanism by which regulates non-coding RNAs is still largely unknown. The present study aimed to assess effect on malignant behaviors colorectal carcinoma (CRC) explore underlying regulatory YAP1-MALAT1-miR-126-5p axis. was highly expressed CRC tissues as assessed GSE20916 its expression negatively correlated with overall survival 83 cases....
Tumor metastasis is the leading cause of death in patients with colorectal cancer (CRC). Circular RNAs (circRNAs) have been shown to be involved progression. However, regulatory mechanisms circRNAs CRC tumor are currently unknown. Methods: High-throughput sequencing was performed on 6 pairs and adjacent normal tissues identify expression profiles mRNA circRNA. circ1662 assessed by RNA-ISH IHC a tissue chip. The function evaluated knocking down or overexpressing circ1662. MeRIP-qPCR,...
Abstract Reactive oxygen species (ROS) plays a critical role in tissue repair, including bone. Therefore, detecting and regulating ROS is essential for monitoring facilitating bone repair. In this study, the first time, spatiotemporal profile of ROS, represented by hydrogen peroxide (H 2 O ), injury microenvironment using photoacoustic imaging technique visualized. The levels significantly increase upon injury, peak at certain stage healing, then gradually decrease toward baseline level. To...
Abstract Background Glycolysis plays an essential role in the growth and metastasis of solid cancer has received increasing attention recent years. However, complex regulatory mechanisms tumour glycolysis remain elusive. This study aimed to explore molecular effect mechanism noncoding RNA miR-103a-3p on colorectal (CRC). Methods We explored effects biological functions CRC cells vitro vivo. Furthermore, we investigated whether regulates HIF1A expression through Hippo/YAP1 pathway, evaluated...
Background Accumulating evidence demonstrates that an increased tumor-associated macrophage abundance is often associated with poor prognosis in colorectal cancer (CRC). The mechanism underlying the effect of tumor-derived exosomes on M2 polarization remains elusive. Results novel circular RNA circPOLQ exhibited significantly higher expression CRC tissues than paired normal tissues. Higher was poorer patients CRC. In vitro and vivo experiments showed exosomal did not directly regulate cell...
Abstract The distinctive structure and composition of the Haversian canal within osteons play a pivotal role in sustaining nutritional supply to individual bone cells. Consequently, osteon's inherent advantages facilitating repair have garnered increasing attention. However, most existing designs emulate only partial aspects architecture, failing replicate its functionality comprehensively. This study aimed develop functional 3D biomimetic osteon enhance regeneration. To achieve this,...
Telomerase, the enzyme that elongates telomeric DNA (TTAGGG)n, may be involved in cellular immortality and oncogenesis. To investigate effect of inhibition telomerase on tumor cells, we transfected antisense vector against human RNA into malignant glioma cells exhibiting activity. After 30 doublings, some subpopulations transfectants expressed a high level interleukin-1beta-converting (ICE) protein underwent apoptosis. In contrast, other also showed enhanced ICE but escaped from apoptotic...
Background The exosomes contain many important proteins that can be used for early tumor diagnosis or patient prognosis analysis. In this study, we investigated plasma exosome-derived sentrin SUMO-specific protease 1 (SENP1) levels as a prognostic biomarker in patients with osteosarcoma. Methods expression of SENP1 protein osteosarcoma tissues and adjacent was detected by immunohistochemistry (IHC). were identified transmission electron microscopy, nanoparticle tracking analysis, western...
Abstract Objective: The senescence of nucleus pulposus (NP) cells induced by oxidative stress is one the important causes intervertebral disc degeneration (IDD). Herein, we investigated role and action mechanism silent information regulator 1 (SIRT1) in stress-induced rat NP cell. Methods: Premature was sublethal concentration hydrogen peroxide (H2O2) (100 μM). SIRT1 activated with SRT1720 (5 μM) to explore its effect on senescence. FoxO1 Akt were inhibited AS1842856 (0.2 MK-2206 μM),...
Abstract T1/ ST 2, an orphan receptor with homology the interleukin ( IL )‐1 family, is ligand‐binding component of for cytokine ‐33, a newly identified known to amplify T h2 cell‐dominant immune responses. The function ‐33/ 2 signalling during respiratory syncytial virus RSV ) infection not fully known. In this study, following intranasal , BALB /c mice showed marked increase in production elevated expression mRNA as well massive infiltration CD 45 + cells lungs, suggesting that early phase...
Long noncoding RNAs (LncRNAs) play a crucial role in cell growth, development, and various diseases related to the central nervous system. However, LncRNA differential expression profiles spinal cord injury are yet be reported. In this study, we profiled pattern of LncRNAs using microarray method contusion (SCI) mouse model. Compared with without injury, few changes levels were noted 1 day after injury. The peaked week SCI subsequently declined until 3 weeks Quantitative real-time polymerase...
Osteosarcoma is the most frequent malignant bone tumor, affecting extremities of adolescents and young adults. Ubiquitin-specific protease 1 (USP1) plays a critical role in many cellular processes including proteasome degradation, chromatin remodeling cell cycle regulation. In present study, we discovered that USP1 was overexpressed 26 out 30 osteosarcoma tissues compared to cartilage tumor normal tissues. We then constructed lentiviral vector mediating RNA interference (RNAi) targeting...