A5004273251- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Hippo pathway signaling and YAP/TAZ
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Immune cells in cancer
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Digestive system and related health
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal motility and disorders
- Cancer Research and Treatments
- Ion Transport and Channel Regulation
- Surgical Simulation and Training
- Congenital gastrointestinal and neural anomalies
First Affiliated Hospital of Zhengzhou University
2016-2025
Traditional Chinese Medicine Hospital of Kunshan
2024
Shanghai University of Traditional Chinese Medicine
2024
Sixth Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2017-2023
Nantong University
2023
Affiliated Hospital of Nantong University
2023
Zhengzhou University
2011-2018
Xinjiang Medical University
2017
Tumor Hospital of Xinjiang Medical University
2017
Yes-associated protein 1 (YAP1) exerts significant effects in various malignancies. However, the oncogenic role of YAP1 remains controversial, and mechanism by which regulates non-coding RNAs is still largely unknown. The present study aimed to assess effect on malignant behaviors colorectal carcinoma (CRC) explore underlying regulatory YAP1-MALAT1-miR-126-5p axis. was highly expressed CRC tissues as assessed GSE20916 its expression negatively correlated with overall survival 83 cases....
<h3>Background</h3> Colorectal cancer (CRC) is one of the most common forms worldwide. The tumor microenvironment plays a key role in promoting occurrence chemoresistance solid cancers. Effective targets to overcome resistance are necessary improve survival and prognosis CRC patients. This study aimed evaluate molecular mechanisms that might be involved patients with CRC. <h3>Methods</h3> We evaluated effects CCL20 on by recruitment regulatory T cells (Tregs) vitro vivo. <h3>Results</h3>...
Tumor metastasis is the leading cause of death in patients with colorectal cancer (CRC). Circular RNAs (circRNAs) have been shown to be involved progression. However, regulatory mechanisms circRNAs CRC tumor are currently unknown. Methods: High-throughput sequencing was performed on 6 pairs and adjacent normal tissues identify expression profiles mRNA circRNA. circ1662 assessed by RNA-ISH IHC a tissue chip. The function evaluated knocking down or overexpressing circ1662. MeRIP-qPCR,...
MRI is the gold standard for confirming a pelvic lymph node metastasis diagnosis. Traditionally, medical radiologists have analyzed image features of regional nodes to make diagnostic decisions based on their subjective experience; this diagnosis lacks objectivity and accuracy. This study trained faster region-based convolutional neural network (Faster R-CNN) with 28,080 images metastasis, allowing Faster R-CNN read those diagnoses. For clinical verification, 414 cases rectal cancer at...
Abstract Background Glycolysis plays an essential role in the growth and metastasis of solid cancer has received increasing attention recent years. However, complex regulatory mechanisms tumour glycolysis remain elusive. This study aimed to explore molecular effect mechanism noncoding RNA miR-103a-3p on colorectal (CRC). Methods We explored effects biological functions CRC cells vitro vivo. Furthermore, we investigated whether regulates HIF1A expression through Hippo/YAP1 pathway, evaluated...
Abstract Background Cancer is a thorny problem which cannot be conquered by mankind at present and recent researchers have put their focus on tumor microenviroment. Neutrophils, the prominent leukocytes in peripheral blood that accumulate tumours, serves as frontline cells response to tumour progression owing rapid development of micro biotechnology. Hence, targeted therapy with these neutrophils has made targeting treatment promising field cancer therapy. Main body We broadly summarise some...
Recent studies have reported that microRNAs (miRNAs) often function as negative post-transcriptional regulators with altered expression levels found in colorectal cancer (CRC). There been few on miRNAs regulate the oncogenic alterations CRC. Here, we aim to explore anti-cancer miRNA and potential mechanisms by which modulate CRC progression. We performed an integrated analysis of datasets The Cancer Genome Atlas (TCGA). lowest expression, miR-760, was validated independent validation sample...
Increasing evidence demonstrates that long non-coding RNAs (lncRNAs) regulate diverse cellular processes and cancer progression. Whether lncRNAs play any functional role in colorectal carcinoma (CRC) remains largely unknown. The aim of this study was to investigate the lncRNA CPS1 intronic transcript 1 (CPS1-IT1) CRC.Expression CPS1-IT1 initially assessed human CRC tissues a series cell lines. correlations between levels survival outcomes were analyzed elucidate clinical significance CRC....
CD8+ T cell trafficking to the tumor site is essential for effective colorectal cancer (CRC) immunotherapy. However, mechanism underlying infiltration in tissues not fully understood. In present study, we investigated CRC and role of chemokine-chemokine receptor signaling regulation recruitment.We screened chemokines cytokines healthy donor from early- advanced-stage patients using multiplex assays PCR screening. We also utilized transcription factor activation profiling arrays established a...