A5081248483- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Peptidase Inhibition and Analysis
- Molecular Biology Techniques and Applications
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- Ultrasound and Hyperthermia Applications
- Drug Transport and Resistance Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Advanced Fluorescence Microscopy Techniques
- Nanoplatforms for cancer theranostics
Sun Yat-sen University
2009-2024
Nanjing University of Chinese Medicine
2021-2024
The First Affiliated Hospital, Sun Yat-sen University
2007-2024
Xijing Hospital
2024
Air Force Medical University
2013-2024
Nanjing University of Posts and Telecommunications
2024
Affiliated Hospital of Guizhou Medical University
2024
Tianjin Medical University Cancer Institute and Hospital
2015-2024
Chengdu University of Traditional Chinese Medicine
2024
University of Cambridge
2012-2023
Despite the great potential of cuproptosis in tumor therapy, current cuproptosis‐based therapy still suffers from compromised efficiency immune activation. Pyroptosis, a proinflammatory cell death modality, provides good opportunity to induce immunogenic (ICD) and promote systemic response. However, synergistic pyroptosis has not been fully explored. Herein, it is discovered that Cu(II)‐based metal–organic framework (MOF) nanoparticles (NPs) can synergistically evoke ICD for high‐efficiency...
Polyethylenimine (PEI) is a class of cationic polymers proven to be effective for gene delivery. However, PEI nondegradable and the molecular weight affects cytotoxicity transfer activity. Aiming prepare biodegradable vector with high transfection efficiency low cytotoxicity, we conjugated (LMW) PEIs backbone polyglutamic acids derivative (PEG-b-PBLG) by aminolysis form combined PEG-b-PLG-g-PEIs (GGI). Two copolymers, GGI 30 40, were synthesized. The chemistry was characterized using IR, 1H...
Abstract Hypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast cancer stroma are less studied. So, the study was aimed to investigate role cancer-associated fibroblasts (CAFs) cells cancer. circRNA array analysis performed screen differential expressed circRNAs between and normoxic CAFs exosomes. Candidate circHIF1A (circ_0032138) screened out it confirmed that up-regulated their Through investigating cellular functions including cell proliferation stem...
Increasing evidence demonstrates that long non-coding RNAs (lncRNAs) regulate diverse cellular processes and cancer progression. Whether lncRNAs play any functional role in colorectal carcinoma (CRC) remains largely unknown. The aim of this study was to investigate the lncRNA CPS1 intronic transcript 1 (CPS1-IT1) CRC.Expression CPS1-IT1 initially assessed human CRC tissues a series cell lines. correlations between levels survival outcomes were analyzed elucidate clinical significance CRC....
Abstract Research in intelligent drug delivery systems within the field of biomedicine promises to enhance efficacy at disease sites and reduce associated side effects. Mesoporous silica nanoparticles (MSNs), characterized by their large specific surface area, appropriate pore size, excellent biocompatibility, have garnered significant attention as one most effective carriers for delivery. The hydroxyl groups on are active functional groups, facilitating easy functionalization. installation...
The NuRD (nucleosome remodeling and deacetylase) complex serves as a crucial epigenetic regulator of cell differentiation, proliferation, hematopoietic development by coupling the deacetylation demethylation histones, nucleosome mobilization, recruitment transcription factors. core function mammalian is executed helicase-domain-containing ATPase CHD4 (Mi-2β) subunit, which also contains N-terminal plant homeodomain (PHD) chromo domains. mode regulation chromatin not well understood, nor role...
Tamoxifen resistance remains to be a huge obstacle in the treatment of hormone-dependent breast cancer, and this therefore highlights dire need explore underlying mechanisms. The epithelial-mesenchymal transition (EMT) is molecular process through which an epithelial cell transfers into mesenchymal phenotype. Roles EMT embryo development, cancer invasion metastasis have been extensively reported. Herein, we established tamoxifen-resistant MCF-7/TR cells showed that underwent driven by...
Long noncoding RNA HOTAIR has been detected in the serum of patients with various malignances and may be served as novel biomarker for diagnosis prognosis prediction breast cancer. However, value circulating to predict response neoadjuvant chemotherapy (NAC) remains unclear.In present study, we analyzed whether pretreatment levels NAC investigated prognostic impact on disease-free survival (DFS) cancer treated NAC.Circulating 112 before were measured using quantitative real-time PCR. The...
Background: The role of B7-H3 in acute monocytic leukemia U937 cells has not been thoroughly investigated. Materials and methods: knockdown the cell line was performed using small hairpin (sh)RNA lentivirus transduction. effects on proliferation, cycle, migration, invasion were investigated by Cell Counting Kit-8 assay, methyl cellulose colony-forming propidium iodide staining, Transwell assays vitro. Changes growth inhibition apoptosis, when combined with chemotherapy drugs, determined...
Abstract Background Circular RNAs (circRNAs) have been reported to play vital roles in colorectal cancer (CRC). However, only a few circRNAs experimentally validated and functionally described. In this research, we aimed reveal the functional mechanism of circCSPP1 CRC. Methods 36 DOX sensitive resistant CRC cases participated study. The expression circCSPP1, miR-944 FZD7 were detected by quantitative real time polymerase chain reaction (qRT-PCR) protein levels FZD7, MRP1, P-gp LRP western...
Hypoxia, a common phenomenon during the development of malignant solid tumors including breast cancer, serves to propagate cascade molecular pathways triggered by hypoxia-inducible factor-1α (HIF-1α). Carbonic anhydrase IX (CA IX), one target genes HIF-1α, has been reported be involved in progression tumors. The objective this study was investigate expression HIF-1α and CA hypoxia, involvement regulation migration invasion/metastasis its prognostic significance cancer. We used cobalt...
We have investigated the potential anticancer effects of karanjin, a principal furanoflavonol constituent Chinese medicine Fordia cauliflora, using cytotoxic assay, cell cycle arrest, and induction apoptosis in three human cancer lines (A549, HepG2 HL-60 cells). MTT assay showed that karanjin could inhibit proliferation viability all cells. The arrest was observed via PI (propidium iodide)/RNase Staining Buffer detection kit analyzed by flow cytometry: dose-dependently induce at G2/M phase...
Nucleoplasmin is a histone chaperone that consists of pentameric N-terminal domain and an unstructured C-terminal tail. The core domain, doughnut-like structure with central pore, only found in the nucleoplasmin family. Here, we report first nucleoplasmin-like (NPL) from unrelated Drosophila protein, FKBP39, present evidence this protein associates chromatin. Furthermore, show two other chromatin proteins, Arabidopsis thaliana deacetylase type 2 (HD2) Saccharomyces cerevisiae Fpr4, share NPL...
Ubiquitin-specific protease 7 (USP7) is a de-ubiquitin enzyme that plays an essential role in multiple cancers and becomes target for treatment. However, the of USP7 its therapeutic value HCC remains unclear.USP7 expression was examined tissues by western blot immunohistochemistry. The correlation prognosis analyzed Kaplan-Meier survival method. Mass spectrometry determined cell proliferation tumorigenicity assays were conducted vitro vivo treated P22077 sgRNA-USP7.USP7 significantly...
Abstract Itraconazole, an FDA-approved antifungal, has antitumor activity against a variety of cancers. We sought to determine the effects itraconazole on esophageal cancer and elucidate its mechanism action. Itraconazole inhibited cell proliferation induced G1-phase cell-cycle arrest in squamous carcinoma adenocarcinoma lines. Using unbiased kinase array, we found that downregulated protein AKT phosphorylation OE33 cells. also decreased downstream ribosomal S6, transcriptional expression...
B7-H3 (CD276), known as a member of B7 immunoregulatory family, is type I transmembrane glycoprotein aberrantly expressed in numerous types cancer and associated with poor prognosis. However, the role oncogenesis chemosensitivity mantle cell lymphoma (MCL) remains unknown. We determined effects downregulating expression on tumor progression sensitivity chemotherapeutic drug lymphoma. knockdown was performed using lentivirus transduction Maver Z138 lines, respectively. The proliferation,...
Abstract Increasing evidence shows that circular RNAs (circRNAs) play a regulatory role in cancer. In the present study, we aimed to investigate characteristics and effects of hsa_circ_0026134 hepatocellular carcinoma (HCC). We investigated expression 20 pairs clinical tissues from HCC patients; different cell lines; effect on proliferation invasion mechanisms interactions among hsa_circ_0026134, miR-127-5p, tripartite motif-containing protein 25 (TRIM25) insulin-like growth factor 2...
The promyelocytic leukemia protein (PML) plays an essential role in multiple pathways of apoptosis. Our previous study showed that PML enhances tumor necrosis factor-induced apoptosis by inhibiting the NFκB survival pathway. To continue exploring mechanism PML-induced apoptosis, we performed a DNA microarray screening target genes using PML-inducible stable cell line. We found Survivin was one downstream PML. Cotransfection experiments demonstrated PML4 repressed transactivation promoter...