A5013178572- Signaling Pathways in Disease
- Medieval Literature and History
- Cancer, Hypoxia, and Metabolism
- Authorship Attribution and Profiling
- Historical Studies of British Isles
- Microbial Metabolic Engineering and Bioproduction
- Genetic Mapping and Diversity in Plants and Animals
- Digital Humanities and Scholarship
- Spaceflight effects on biology
- Bacterial Genetics and Biotechnology
- Smart Agriculture and AI
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- Ubiquitin and proteasome pathways
- Photosynthetic Processes and Mechanisms
- Carbon dioxide utilization in catalysis
- CO2 Reduction Techniques and Catalysts
- Carbon Dioxide Capture Technologies
- Circadian rhythm and melatonin
- Viral Infectious Diseases and Gene Expression in Insects
- Wnt/β-catenin signaling in development and cancer
- Remote Sensing in Agriculture
- Insect Resistance and Genetics
- Hair Growth and Disorders
- Metabolomics and Mass Spectrometry Studies
Max Planck Institute for Biology of Ageing
2019-2021
Max Planck Institute of Molecular Plant Physiology
2016-2019
University of Potsdam
2015-2016
University of Cambridge
2015
Significance Photorespiration limits plant carbon fixation by releasing CO 2 and using cellular resources to recycle the product of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) oxygenation, 2-phosphoglycolate. We systematically designed synthetic photorespiration bypasses that combine existing new-to-nature enzymatic activities do not release . Our computational model shows these could enhance rate under a range physiological conditions. To realize bypasses, glycolate reduction...
The ribulose monophosphate (RuMP) cycle is a highly efficient route for the assimilation of reduced one-carbon compounds. Despite considerable research, RuMP has not been fully implemented in model biotechnological organisms such as Escherichia coli, mainly since heterologous establishment pathway requires addressing multiple challenges: sufficient formaldehyde production, assimilation, and regeneration acceptor, 5-phosphate. Here, by efficiently producing from sarcosine oxidation...
Nucleoplasmin is a histone chaperone that consists of pentameric N-terminal domain and an unstructured C-terminal tail. The core domain, doughnut-like structure with central pore, only found in the nucleoplasmin family. Here, we report first nucleoplasmin-like (NPL) from unrelated Drosophila protein, FKBP39, present evidence this protein associates chromatin. Furthermore, show two other chromatin proteins, Arabidopsis thaliana deacetylase type 2 (HD2) Saccharomyces cerevisiae Fpr4, share NPL...
The engineering of synthetic metabolic routes can provide valuable lessons on the roles different biochemical constraints in shaping pathway activity. In this study, we designed and engineered a novel glycerol assimilation Escherichia coli. While was based only well-characterized endogenous reactions, were not able to establish robust growth using standard concentrations glycerol. Long-term evolution failed improve via pathway, indicating that limitation regulatory but rather relates...
The many source texts that late medieval adaptors like Thomas Malory worked with constitute a potential wealth of information concerning the genesis linguistic and stylistic features shaping their works. As result, provide useful framework for further developing testing methods stylometric analysis in context adaptation as collaborative form authorship. Our interdisciplinary team has undertaken eight different sections Malory's <em>Morte Darthur</em>, order to identify differences between...
Abstract This article draws on computational methods including multi-dimensional scaling and clustering to analyse the contents of Middle English multi-text manuscript London, British Library, Cotton Caligula A.ii (Part One). It makes argument that digital linguistic analysis can complement analogue scholarship collections this kind by providing new perspectives networks intertextuality thematic resonance these groups texts engender. In particular, it argues for use scatterplots dendrograms...