A5100416529- Advanced biosensing and bioanalysis techniques
- Mass Spectrometry Techniques and Applications
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Advanced Proteomics Techniques and Applications
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Electrochemical Analysis and Applications
- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Biosensors and Analytical Detection
- Ubiquitin and proteasome pathways
- Advanced Biosensing Techniques and Applications
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Metabolomics and Mass Spectrometry Studies
- HER2/EGFR in Cancer Research
- Electrochemical sensors and biosensors
- Analytical Chemistry and Chromatography
- Immune Cell Function and Interaction
Nanjing Medical University
2016-2025
State Key Laboratory of Reproductive Medicine
2017-2025
Soochow University
2025
South China Agricultural University
2025
Naval Medical Research Command
2025
The Seventh Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Agricultural Genomics Institute at Shenzhen
2025
Dongguan University of Technology
2024
Naval University of Engineering
2024
Interleukin-22 (IL-22), one of the cytokines secreted by T helper 17 (Th17) cells, was recently reported to be a novel inflammation driver through STAT3 signaling activation. We aimed investigate role IL-22 expression in hepatocellular carcinoma (HCC). demonstrated significant up-regulation human HCC tumor infiltrated leukocytes (TILs) compared peripheral lymphocytes. Moreover, significantly higher Edmondson Grade III-IV patients versus I-II, confirmed both real-time polymerase chain...
Despite a good and overall prognosis, papillary thyroid cancer (PTC) can still affect the quality of life many patients, even be life-threatening due to its invasiveness metastasis. Emerging studies demonstrate that circular RNAs (circRNAs) participate in regulation various cancers. However, circRNA profile invasive PTC is not well understood. Competing endogenous RNA (ceRNA) microarrays were performed determine circRNAs contributed tumorigenesis PTC. Bioinformatics methods used narrow down...
Luminol electrochemiluminescence (ECL) imaging was developed for the parallel measurement of active membrane cholesterol at single living cells, thus establishing a novel electrochemical detection technique cells with high analysis throughput and low limit. In our strategy, luminescence generated from luminol hydrogen peroxide upon potential recorded in one image so that surface multiple could be simultaneously analyzed. Compared classic microelectrode array single-cell analysis, plat...
Wnt signaling is one of the key regulators hepatocellular carcinoma (HCC) tumor progression. In addition to classical receptor frizzled (FZD), various coreceptors including heparan sulfate proteoglycans (HSPGs) are involved in activation. Glypican‐3 (GPC3) an HSPG that overexpressed HCC and functions as a coreceptor modulates cell proliferation. These features make GPC3 attractive target for liver cancer therapy. However, precise interaction how GPC3, Wnt, FZD cooperate with each other...
Abstract The human SLC26 transporter family exhibits various transport characteristics, and member SLC26A9 performs multiple roles, including acting as Cl – /HCO 3 exchangers, channels, Na + transporters. Some mutations of are correlated with abnormalities in respiration digestion systems. As a potential target colocalizing CFTR cystic fibrosis patients, is great value drug development. Here, we present cryo-EM structure the dimer at 2.6 Å resolution. A segment C-terminal end bound to entry...
Abstract Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the “best” indicator metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular typing system to predict colorectal cancer metastasis potential based on metabolic fingerprints single CTCs. After identification metabolites potentially related using mass spectrometry-based untargeted metabolomics, setup home-built single-cell...
Abstract Lead halide perovskite quantum dots (QDs) are promising electrochemiluminescence (ECL) nanoemitters due to their fascinating photophysical properties. However, poor structural stability against the external environment, trade‐off between colloidal and carrier injection/transport efficiency is a major challenge in advancement of perovskite‐based ECL technology. In this work, intense stable from CsPbBr 3 (CPB) QDs achieved by simultaneously encapsulating CPB coreactant (CoR) into situ...
We report a new mass spectrometric method for detecting electrogenerated intermediates. This approach is based on simultaneous activation of electrospray ionization and redox reaction wireless bipolar ultramicroelectrode, which fabricated in the tip quartz nanopipette. The hollow structure ultramicroelectrode permits rapid transferring transient species from electrode-electrolyte interfaces into gas phase identification time scale microseconds. long-sought fleeting intermediates including...
Glioblastoma (GBM) is the deadliest primary brain tumor and generally resistant to immunotherapy because of severe dysfunction T cells. Novel treatment options are critically needed overcome resistance GBM. Here we demonstrate that Zika virus (ZIKV) improves efficacy anti-PD ligand 1 (PD-L1) in We found ZIKV induces a strong pro-inflammatory response increases CD4+ CD8+ cell intratumoral infiltration activation GBM mouse models. mice bearing tumors inhibits growth prolongs survival. These...
The NuRD (nucleosome remodeling and deacetylase) complex serves as a crucial epigenetic regulator of cell differentiation, proliferation, hematopoietic development by coupling the deacetylation demethylation histones, nucleosome mobilization, recruitment transcription factors. core function mammalian is executed helicase-domain-containing ATPase CHD4 (Mi-2β) subunit, which also contains N-terminal plant homeodomain (PHD) chromo domains. mode regulation chromatin not well understood, nor role...
HER2-positive breast cancer correlates with more aggressive tumor growth, a poorer prognosis and reduced overall survival. Currently, trastuzumab (Herceptin), which is an anti-HER2 antibody, one of the key drugs. There evidence indicating that conjugation chemotherapy drugs, such as doxorubicin (DOX), for multiple targets could be effective. However, incomplete penetration into tumors has been noted those conjugates. Compared to peptides may represent attractive alternative. For HER2,...
Abstract Carbonic anhydrase IV (CAIV) is a membrane‐associated enzyme anchored to plasma membrane surfaces by phosphatidylinositol glycan linkage. We have determined the 2.8‐Å resolution crystal structure of truncated, soluble form recombinant murine CAIV. also its complex with drug used for glaucoma therapy, sulfonamide inhibitor brinzolamide (Azopt™). The overall CAIV generally similar that human CAIV; however, some local structural differences are found in active site resulting from amino...
Abstract A doxorubicin (DOX) delivery system of pH‐sensitive micelles self‐assembled from cholesterol conjugated His 5 Arg 10 (HR15‐Chol) and (HR20‐Chol) has been described in this article. The amphiphilic molecules have low critical micelle concentrations 17.8 28.2 μg/mL for HR15‐Chol HR20‐Chol, respectively, even at a pH 5.0. histidine segment the polypeptide block is insoluble 7.4 but becomes positively charged soluble via protonation lower than 6.0. size zeta potential DOX‐loaded...