A5035832797- Ferroptosis and cancer prognosis
- Sulfur-Based Synthesis Techniques
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Chemical Synthesis and Reactions
- Lung Cancer Treatments and Mutations
- Phytochemicals and Antioxidant Activities
- Synthesis and Catalytic Reactions
- Noise Effects and Management
- Bone and Joint Diseases
- Air Quality and Health Impacts
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Toxic Organic Pollutants Impact
- Cancer Genomics and Diagnostics
- Fermentation and Sensory Analysis
- Catalytic C–H Functionalization Methods
- PI3K/AKT/mTOR signaling in cancer
- Bone health and osteoporosis research
- Liver physiology and pathology
- Ovarian cancer diagnosis and treatment
- Saffron Plant Research Studies
- Atmospheric chemistry and aerosols
Institute of Food Science & Technology
2025
Northwest A&F University
2025
Nanjing General Hospital of Nanjing Military Command
2021-2024
Third Hospital of Hebei Medical University
2023-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
Nanjing University
2021-2024
Dalian Medical University
2023-2024
Chongqing Medical University
2023-2024
Fred Hutch Cancer Center
2021-2024
Xi'an University of Science and Technology
2024
Sepsis is a dysregulated response to infection that can result in life-threatening organ failure, and septic cardiomyopathy serious complication involving ferroptosis. Olaparib, classic targeted drug used oncology, has demonstrated potential protective effects against sepsis. However, the exact mechanisms underlying its action remain be elucidated. In our study, we meticulously screened ferroptosis genes associated with sepsis, conducted comprehensive functional enrichment analyses delineate...
Black rice anthocyanin-rich extract and rosmarinic acid ameliorated DSS-induced colitis in mice by down-regulating pro-inflammatory mediators exhibited an additive interaction reducing MPO, NO the expression of some mediators.
The distribution and fractionation of persistent organic pollutants (POPs) in different matrices refer to how these are dispersed separated within various environmental compartments. This is a significant study area as it helps us understand the transport efficiencies long-range potentials POPs enter remote areas, particularly polar regions. provides comprehensive review progress understanding POPs. We focus on contributions four intermedia processes (dry wet depositions for gaseous...
Septic cardiomyopathy (SCM) is associated with an imbalance in mitochondrial quality and high mortality rates, no effective treatment developed to date. Curcumin provides antioxidant, anti-inflammatory, cardiovascular, protection. However, curcumin has not been confirmed improve cardiac dysfunction sepsis. We hypothesized that can reduce abnormal inflammatory responses by improving function as a novel mechanism SCM. To explore this hypothesis, we used vivo male C57BL/6 mouse sepsis model...
The objective of this study was to investigate the molecular interaction and complex stability four major cow's milk (CM) proteins (α-LA, β-LG, αs1-CA, β-CA) with cyanidin-3-O-glucoside (C3G) using computational methods. results docking analysis revealed that hydrogen bond hydrophobic were main binding forces maintain C3G-CM protein complexes. Molecular dynamics simulation showed all complexes except for C3G-αs1-CA found reach equilibrium within 50 ns simulation. αs1-CA β-CA switched a more...
Objectives: Citrobacter freundii is a frequent cause of nosocomial infections and known diarrheal infections, has increasingly becoming multi-drug resistant (MDR). In this study, we aimed to determine the genetic diversity, antimicrobial resistance profiles in vitro virulence properties C. from patients healthy individuals. Methods: 82 were obtained human outpatients Multilocus Sequence Typing (MLST) seven housekeeping genes was performed. Antimicrobial susceptibility testing carried out...
Background Oxidative stress is a significant contributor to the development of various diseases, and oxidative balance score (OBS) valuable tool for assessing impact dietary lifestyle factors on in humans. Nevertheless, precise relationship between OBS thyroid function adults remains elusive. Methods This cross-sectional study comprised 6222 adult participants drawn from National Health Nutrition Examination Survey (NHANES) conducted 2007 2012. Employing weighted multivariable linear...
Long non-coding RNAs (lncRNAs) have been found to show important regulatory roles in various human cancers. Lnc-RNA PANDAR is a novel identified lncRNA that was previously reported abnormal expression pattern However, little known of its and biological function thyroid cancer. Here, we used the quantitative real-time PCR (qRT-PCR) determine 64 cancer tissues. We up-regulated tissues compared with adjacent non-tumor Functional assays vitro demonstrated knockdown could inhibit proliferation,...
Osimertinib, a third‐generation irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI), provides marked clinical benefit for patients with EGFR‐activating mutations. Unfortunately, limited treatments exist who acquire osimertinib resistance. We observed two ‘special’ regained an antitumor response plus aspirin treatment. As previous data indicate that induces antiproliferative effects in tumor cells, we designed preclinical study to explore whether combined could...
The objective of this study was to investigate the structure characteristics flavonoids that act as inhibitors for heterocyclic aromatic amines (HAAs) formation. Five quantitative structure–activity relationship models predicting inhibitory rates HAAs (norharman, harman, PhIP, MeIQx, and 4,8-DiMeIQx) were established using selected chemometric parameters (R2: 0.591–0.920), indicated hydrophobicity, hydroxyl groups, topological played important roles in inhibition 5,7-dihydroxyls...
Context Sepsis can result in critical organ failure, and notoginsenoside R1 (NGR1) offers mitochondrial protection.
Autism spectrum disorder is a serious neurodevelopmental whose early onset significantly affects an individual's social interactions and cognitive function. Recent research suggests that modulating the gut microbiota could be potential intervention strategy for autism symptoms. 2'-Fucosyllactose has been identified as regulator of homeostasis, however, its effectiveness in addressing remains unclear. In this study, effects daily supplementation 2'-FL 3-week-old male offspring mice 5 weeks...
The third-generation epidermal growth factor receptor (EGFR) inhibitor osimertinib is a promising therapeutic option for patients with advanced non-small-cell lung cancer (NSCLC) in second-line or first-line treatment because of its applications selectively inhibiting EGFR T790M and EGFR-tyrosine kinase sensitizing mutations. However, the activation autophagy associated may play protective role NSCLC cells injury induced by osimertinib.The aim present study was to effects osimertinib-induced...
Abstract Background Few studies have explored the modifications by family stress and male gender in relationship between early exposure to traffic-related air pollution (TRAP) allergic rhinitis (AR) risk preschool children. Methods We conducted a case-control study of 388 children aged 2–4 years Shenyang, China. These AR were diagnosed clinicians. By using measured concentrations from monitoring stations, we estimated exposures particulate matter less than 10 μm diameter (PM ), nitrogen...