A5100744099- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Hydrogels: synthesis, properties, applications
- Nanoplatforms for cancer theranostics
- Advanced Sensor and Energy Harvesting Materials
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Electrospun Nanofibers in Biomedical Applications
- Advanced Polymer Synthesis and Characterization
- MXene and MAX Phase Materials
- ATP Synthase and ATPases Research
- Rock Mechanics and Modeling
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Silicone and Siloxane Chemistry
- biodegradable polymer synthesis and properties
- Polymer Surface Interaction Studies
- Conducting polymers and applications
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Circular RNAs in diseases
- 3D Printing in Biomedical Research
- MicroRNA in disease regulation
Chinese Academy of Agricultural Sciences
2025
Capital Medical University
2025
Beijing Friendship Hospital
2025
Shanxi Agricultural University
2025
Chongqing Medical University
2022-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
Dalian Medical University
2023-2024
Xuzhou University of Technology
2015-2024
Nanjing Agricultural University
2024
Southern University of Science and Technology
2024
Single-atom nanozymes (SAzymes), with individually isolated metal atom as active sites, have shown tremendous potential enzyme-based drugs for enzymatic therapy. However, using SAzymes in tumor theranostics remains challenging because of deficient activity and insufficient endogenous H2O2. We develop an external-field-enhanced catalysis by atom-level engineered FeN4-centered nanozyme (FeN4-SAzyme) radio-enzymatic This FeN4-SAzyme exhibits peroxidase-like capable catalyzing H2O2 into hydroxyl...
Metastasis of breast carcinoma is commonly realized through lymphatic circulation, which seriously threatens the lives cancer patients. Therefore, efficient therapy for both primary tumor and metastatic sentinel lymph nodes (SLNs) highly desired to inhibit growth metastasis. During treatment, radiotherapy (RT) a common clinical method. However, efficacy RT decreased by radioresistance hypoxic microenvironment inevitable side effects healthy issues at high radiation doses. Considering...
Dielectric elastomers (DEs) are widely used in soft actuation and sensing. Current DE actuators require high driving electrical fields because of their low permittivity. Most sensors suffer from viscoelastic effects, leading to mechanical loss large shifts signals. This study demonstrates a valuable strategy produce polyvinyl chloride (PVC)-based with permittivity viscoelasticity. The introduction cyanoethyl cellulose (CEC) into plasticized PVC gel (PVCg) not only confers dielectric (18.9@1...
Septic cardiomyopathy (SCM) is associated with an imbalance in mitochondrial quality and high mortality rates, no effective treatment developed to date. Curcumin provides antioxidant, anti-inflammatory, cardiovascular, protection. However, curcumin has not been confirmed improve cardiac dysfunction sepsis. We hypothesized that can reduce abnormal inflammatory responses by improving function as a novel mechanism SCM. To explore this hypothesis, we used vivo male C57BL/6 mouse sepsis model...
DNA double-strand break (DSB) repair is critical for the maintenance of genome stability. The current models mechanism DSB are based on studies proteins. Long non-coding RNAs (lncRNAs) have recently emerged as new regulatory molecules, with diverse functions in biological processes. In present study, we found that expression ionizing radiation-inducible lncRNA, lnc-RI, was correlate negatively micronucleus frequencies human peripheral blood lymphocytes. Knockdown lnc-RI significantly...
We examined the application of six different resins with aim selecting a macroporous resin suitable for purifying Acanthopanax senticosus total flavonoids (ASTFs) from crude extract (EAS) by comparing their adsorption/desorption capacities, which led to selection HPD-600. Research on adsorption mechanism showed that process had pseudo-second-order kinetics and fit Freundlich model. Moreover, analysis thermodynamic parameters indicated is spontaneous endothermic. The optimal conditions...
The hydrodeoxygenation of lactic acid (LA) to propionic (PA) is great significance for the conversion biomass valuable products; however, it remains a challenge because trade-off between LA and PA selectivity. Here, we prepared ultrathin MoS2 nanosheets containing rich sulfur vacancies by lithium exfoliation. With increase exfoliation time, vacancy in accordingly increased adsorption activation on enhanced. Increasing lowered valence band simultaneously enhanced dissociation H2 molecule....
Oral squamous cell carcinoma (OSCC) is one of the most common oral malignancies. Radiotherapy primary noninvasive treatment OSCC for avoiding surgery-induced facial deformities and impaired function. However, specificity in situ limits radiotherapeutic effects because hypoxia-induced low radiosensitivity tumors radiation tolerance surrounding normal tissues. Here, we design a highly efficient low-toxic radiosensitization strategy. On hand, biocompatible poly(vinyl pyrrolidone)-modified...
Excessive mitochondrial fission following ischemia and hypoxia relies on the formation of contacts between endoplasmic reticulum mitochondria (ER-Mito); however, specific mechanisms behind this process remain unclear. Confocal microscopy time course recording are used to investigate how affect activation dynamin-related protein 1 (Drp1), a central dynamics, ER-Mito interactions, consequences modifying expression Drp1, shroom (Shrm) 4, inverted formin (INF) 2 contact establishment. Both Drp1...
Taking the water level fluctuating zone of Danjiangkou Reservoir as a case, and by method hierarchical cluster analysis, soil seed banks at 37 sampling plots within areas 140-145 m elevation were divided into 6 groups, species composition, density, diversity among groups compared. The differences between aboveground vegetations analyzed S0rensen similarity coefficient, correlations banks, vegetations, environmental factors explored principal component analysis (PCA) multivariable regression...
The structure and properties of conventional, singly crosslinked, pH-responsive microgel particles (SX microgels) have been extensively studied. Recently, doubly crosslinked microgels (DX reported. These are a new type hydrogel that constructed from covalently linked SX microgels. In this study we report for the first time an investigation class DX which pH responsive. were prepared using covalent linking physically gelled dispersions inter-penetrating, vinyl-functionalised used...
Abstract Membrane type 1-matrix metalloproteinase (MT1-MMP) is associated with enhanced tumorigenicity in many cancers. A recent study has revealed that MT1-MMP induces epithelial-to-mesenchymal transition (EMT) prostate and breast cancer cells. However, its role esophageal squamous cell carcinoma (ESCC) not been studied. Here, we investigated the of dissemination ESCC. Expression was detected by immunohistochemistry tissue microarray 88 Kazakh ESCC patients. Western blotting performed to...
The objective of the current study was to discover how processing technology affects beany flavor soymilk. Four different routes, namely soaked soybean-boiling before filtration, after dry filtration (DS-BBF soymilk), and 26 soy cultivars were utilized process nine odor compounds hexanal, hexanol, trans-2-nonenal, 1-octen-3-ol, trans,trans-2,4-decadienal, benzaldehyde, 2-pentyl furan, 1-octen-3-one, trans,trans-2,4-nonadienal detected by headspace gas chromatography using 2-methyl...
The past decades have witnessed an increasing interest in the exploration of room temperature gallium-based liquid metal (LM) field microfluidics, soft robotics, electrobiology, and biomedicine. Herein, this study for first time reports utilization nanosized gallium-indium eutectic alloys (EGaIn) as a radiosensitizer enhancing tumor radiotherapy. sodium alginate (Alg) functionalized EGaIn nanoparticles (denoted EGaIn@Alg NPs) are prepared via simple one-step synthesis method. coating Alg not...
In order to improve the aqueous solubility and enhance bioavailability of Hyperoside (Hyp), three inclusion complexes (ICs) Hyp with 2-hydroxypropyl-β-cyclodextrin (2H-β-CD), β-cyclodextrin (β-CD), methyl-β-cyclodextrin (M-β-CD) were prepared using ultrasonic method. The characterization was achieved Fourier-transform infrared spectroscopy (FTIR), scanning electronic microscopy (SEM), X-ray powder diffraction (XRPD), thin-layer chromatography (TLC), 1H nuclear magnetic resonance (1H NMR)....