A5057905036- Osteoarthritis Treatment and Mechanisms
- Exercise and Physiological Responses
- CAR-T cell therapy research
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Winter Sports Injuries and Performance
- Aquaculture Nutrition and Growth
- Fungal and yeast genetics research
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Biochemical effects in animals
- T-cell and B-cell Immunology
- Polysaccharides Composition and Applications
- GABA and Rice Research
- Bacillus and Francisella bacterial research
- Bone and Joint Diseases
- TGF-β signaling in diseases
- Laser Applications in Dentistry and Medicine
- Prion Diseases and Protein Misfolding
- Musculoskeletal synovial abnormalities and treatments
- Radiation Detection and Scintillator Technologies
- Nanoparticle-Based Drug Delivery
- High Altitude and Hypoxia
Yale University
2025
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
Sun Yat-sen University
2016-2023
China Academy of Engineering Physics
2008-2022
First Affiliated Hospital of Shihezi University Medical College
2017-2021
Shihezi University
2014-2020
Union Hospital
2017-2020
Huazhong University of Science and Technology
2017-2020
The University of Queensland
2020
Invasion and metastasis are the major causes of death in patients with esophageal squamous cell carcinoma (ESCC). Epithelial-mesenchymal transition (EMT) is a critical step tumor progression transforming growth factor-β1 (TGF-β1) signaling has been shown to play an important role EMT. In this study, we investigated how TGF-β1 pathways contributed EMT three ESCC lines as well 100 nomadic ethnic Kazakhs residing northwest Xinjiang Province China. vitro analyses included Western blotting detect...
Abstract Membrane type 1-matrix metalloproteinase (MT1-MMP) is associated with enhanced tumorigenicity in many cancers. A recent study has revealed that MT1-MMP induces epithelial-to-mesenchymal transition (EMT) prostate and breast cancer cells. However, its role esophageal squamous cell carcinoma (ESCC) not been studied. Here, we investigated the of dissemination ESCC. Expression was detected by immunohistochemistry tissue microarray 88 Kazakh ESCC patients. Western blotting performed to...
This study compared the physiological characteristics and transcriptomic profiles of single-budded multi-budded corms, as well developmental stages foliar bulbils in Amorphophallus muelleri, to reveal regulatory mechanisms underlying bud development. Hormonal analysis showed that IAA/CTK ratio was significantly higher corms (1.9060 vs 1.5753), while exhibited CTK (0.2766 μg/g), BR (0.8692 p mol/g), SLs (0.5090 ng/g) levels. During development, ABA content peaked at 41.54 ng/g G2 stage,...
Programmed death one homolog (PD-1H) is an immunoglobulin superfamily molecule and primarily acts as a coinhibitor in the initiation of T cell response to antigens. Here, we report that genetic ablation PD-1H mice blocks differentiation naive cells Foxp3+ inducible Treg (iTreg) with significant decrease iTreg lymphoid organs. This effect highly specific for because both naturally generated gut-related tissues vitro induced by TGF-β were decreased whereas genesis natural (nTreg) remains...
Targeted delivery of therapeutic drugs using nanoparticles to the highly aggressive triple negative breast cancer cells has potential reduce side effects and drug resistance. Cell entry into can be enhanced by incorporating cell binding receptor molecules on surface enhance receptor-mediated pathways, including clatherin or caveolae endocytosis. However, for cells, these pathways may not effective, with more rapid high volume uptake from macropinocytosis phagocytosis being significantly...
A growth trial was conducted to examine the effect of dietary digestible energy (DE) content on methionine (Met) utilization and requirement in juvenile Nile tilapia (Oreochromis niloticus). Ten iso-nitrogenous (288 g kg−1 protein) practical diets, with two DE levels (10.9 MJ kg−1; 12.4 kg−1) five supplementation (0, 1, 2, 4 6 kg−1), were hand-fed twice daily triplicate groups (initial body weight 8.95 ± 0.06 g) for 8 weeks. Weight gain (WG) specific rate (SGR) increased significantly...
The inhibitory effect of binary toxic (Bin) protein produced by Lysinibacillus sphaericus IAB872 on cell proliferation human lung, liver, stomach and cervical tumor lines was assessed using MTT assay. Bin A549 proliferation, apoptosis, cycle, migration invasion were examined assay, Western blotting, Immunocytochemical staining, flow cytometry assay wound-healing Results showed that inhibits a range cancer cells in vitro. anti-proliferative is associated with apoptosis as result an increased...
Abstract This paper presented a mobile CsI gamma detector developed to solve the problem of radioactive source detection in wide area. The performance was illustrated during spectra collection investigation. 1-s spectrum collected by low-count signal, which is hard distinguish whether it contained signal or not. A rapid method based on proposed. Principal component analysis (PCA) key technology able extract information efficiently. proposed improved sensitivity and accuracy.
[PSI(+)] phenotype can be transiently induced when Magnesium chloride (MgCl(2)) was the selective pressure in SUP35 repeat-expansion mutant [psi(-)] yeast strains. We further investigated change under different MgCl(2) conditions with native Sup35p and quantified status changes fluorescence recovery after photobleaching (FRAP) semi-denaturing detergent-agarose gel electrophoresis (SDD-AGE) analysis. It found that presented a dose-dependent relationship concentrations of MgCl(2). Furthermore,...