A5101753251- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cardiac Ischemia and Reperfusion
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Antibiotic Resistance in Bacteria
- RNA Research and Splicing
- Cardiovascular Disease and Adiposity
- Infections and bacterial resistance
- Environmental and Agricultural Sciences
- 3D Surveying and Cultural Heritage
- Lipid metabolism and disorders
- Environmental Changes in China
- Liver Disease Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Anesthesia and Neurotoxicity Research
- Alcohol Consumption and Health Effects
- ATP Synthase and ATPases Research
- Osteoarthritis Treatment and Mechanisms
- Nanoparticle-Based Drug Delivery
- Renal cell carcinoma treatment
- Advanced Nanomaterials in Catalysis
305 Hospital of People Liberation Army
2024-2025
Shanghai Jiao Tong University
2013-2024
Central Hospital of Zibo
2024
Chinese People's Liberation Army
2022-2024
Ruijin Hospital
2012-2024
Chinese PLA General Hospital
2022-2024
People's Liberation Army No. 150 Hospital
2023
Shanghai Institute of Materia Medica
2020-2023
Chinese Academy of Sciences
2019-2023
Southern Medical University
2023
Fructose as a daily sweetener is widely recognized risk catalyst for nonalcoholic fatty liver disease (NAFLD). The aim of current study to evaluate the effects and molecular mechanism by which polyphenol-rich loquat fruit extract (LFP) prevents NAFLD in mice fed 30% fructose water (HF) 8 weeks. Administration LFP HF-fed mitigated abnormal body weight, disordered lipid metabolism, oxidative stress, inflammation through regulated AKT, ChREBP/SREBP-1c, Nrf2, TLR4/MyD88/TRIF pathways. caused...
Early detection of acute kidney injury is difficult due to lack known biomarkers; previous studies have tried identify new biomarkers for detecting at an early stage. MicroRNA, a 21-23 nucleotide noncoding RNA molecule, has emerged as desirable marker in the diagnosis and prognosis various diseases. This study aims expression profile microRNA ischemia–reperfusion-induced determine possibility using candidate biomarker I/R-induced injury. Based on established rat model injury, microarray...
Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generation RNA isoforms with distinct 3' termini. Increasing evidence has revealed that APA actively involved in development and disease, including hepatocellular carcinoma (HCC). However, how functions tumor formation progression remains elusive. In this study, we investigated the role cleavage factor I (CFIm) subunit CPSF6 human (HCC).Expression levels clinical tissues cell lines were...
The present study aimed to evaluate the effects of ulinastatin on permeability and apoptosis lipopolysaccharide (LPS)-induced cardiac microvascular endothelial cells (CMVECs), investigate its molecular mechanisms in sepsis. sepsis rat model was induced by cecal ligation puncture (CLP), CMVECs were isolated treated with LPS or/and ulinastatin. Then, cell evaluated transendothelial electrical resistance, reactive oxygen species (ROS) levels assessed 2,7-dichlorofluorescein diacetate, detected...
As a noninvasive blood testing, the detection of cell-free DNA (cfDNA) methylation in plasma has raised an increasing interest due to diagnostic applications. Although extensively used cfDNA analysis, bisulfite sequencing is less cost-effective. In this study, we investigated patterns lung cancer patients by MeDIP-seq. Compared with healthy individuals, 330 differentially methylated regions (DMRs) at gene promoters were identified 33 hypermethylated and 297 hypomethylated regions,...
Background: With the recent evolution of multidrug-resistant strains, genetic characteristics foodborne Salmonella enterica serovar Enteritidis and clinical isolates have changed. ST11 is now most common genotype associated with S. isolates. Methods: A total 83 strains were collected at General Hospital People’s Liberation Army. Of these, 37 from aseptic sites in patients, 11 feces patients diarrhea, remaining 35 chicken-origin. The minimum inhibitory concentration was determined by broth...
Previous studies have shown that Atp6v1c1, a regulator of the assembly V0 and V1 domains V-ATPase complex, is up-regulated in metastatic oral tumors.Despite these studies, function Atp6v1c1 tumor growth metastasis still unknown.Atp6v1c1's expression squamous cell carcinoma indicates has an important cancer metastasis.We hypothesized elevated essential to promotes through activation activity.To test this hypothesis, Lentivirus-mediated RNAi knockdown approach was used study mouse 4T1 mammary...
In this retraction note, we have decided to retract an article published in World Journal of Psychiatry due disagreement among the authors.
To fully reveal impacts of agronomic managements on yield-nutrition relationships in maize kernels for micronutrient biofortification while enhancing yields simultaneously, effects various soil fertilization and drone-based foliar spraying measures were studied. Maize grain Zn concentrations simultaneously increased by 12.4%-23.0% 41.4%-110.1%, respectively, the experiment. Soil improvements extra-addition humic acid (HA), bio-organic (BO) and/or Ca-Mg-S-Si fertilizers into calcareous tested...
AimsWe here investigated the endothelial effects of chromogranin A-derived peptide vasostatin-2 and its relation to coronary artery disease (CAD).
Atmospheric deposition samples were collected over 15 mo at several locations near an operating smelter and abandoned Pb to investigate the contribution of smelting depositional fluxes potential local air quality degradation. Samples analyzed for As, Cd, Cu, Pb, Zn subjected scanning electron microscopy (SEM)-energy dispersive spectroscopy (EDS). Concentrations Cd both sites greater than control site (p < .05), significant correlations existed between concentrations .05). Monthly flux...
Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an important pathogen causing hospital-associated outbreaks worldwide. The spread of K. carbapenemase-2 (KPC-2)-producing CRKP primarily associated with sequence type (ST) 11. Methods A total 152 KPC-2-producing ST11 isolates were collected from the respiratory department a tertiary care hospital in Beijing, China between 2009 and 2018. genome sequencing these was performed on HiSeq X Ten sequencer. Multilocus typing (MLST),...
Traditional Chinese Medicine (TCM) has been extensively used in clinical practices and proven to be effective against cancer. However, the underlying mechanisms remain investigated. In this study, we examined anticancer activities of herbal formula Yangyinjiedu (YYJD) found that YYJD exhibits cytotoxicity lung cancer cells. Transcriptome analysis indicated 2178 genes were differentially expressed (P < 0.05) upon treatment, with 1464 being (67.2%) up-regulated. Among these, tumour suppressor...
Recent studies have shown osteocalcin (OC) plays an important role in regulating glucose and lipid metabolism. Thus, the aim of this study was to investigate association OC with metabolism patients type 2 diabetes mellitus (T2DM) Chinese Han Uygur population.A total 1397 T2DM (705 692 patients) were enrolled present study. Lipid profile, metabolic indices (TOC) measured. Homeostasis model assessment β-cells function (HOMA-β), insulin sensitivity (HOMA-IS) resistance (HOMA-IR) also calculated...
Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA involved in cell self-renewal, development, immunity, and cancer. CPSF6 one of the core proteins CFIm complex modulate process. Although it has been reported to play oncogenic roles cancer, underlying mechanisms remain unclear. The aim present study was characterize human gastric cancer (GC). We observed upregulated GC. Knockdown...
To compare the treatment outcome of laparoscopic versus open surgery for renal masses with infrahepatic (levels I and II) tumor thrombus analyze largest series retroperitoneal experience in such cases from China.Forty-nine patients were analyzed retrospectively between January 2009 2013 at our institution. The diagnosis was confirmed by computed tomography and/or magnetic resonance imaging preoperatively. They divided into two groups based on detailed surgical approach applied. Group 1 (A,...