A5052492909- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Folate and B Vitamins Research
- Endoplasmic Reticulum Stress and Disease
- Diabetes Treatment and Management
- Retinal Diseases and Treatments
- Gout, Hyperuricemia, Uric Acid
- Nuclear Receptors and Signaling
- Diabetes Management and Research
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Animal Disease Management and Epidemiology
- Alcohol Consumption and Health Effects
- Mitochondrial Function and Pathology
- Influenza Virus Research Studies
- Autophagy in Disease and Therapy
- Gas Sensing Nanomaterials and Sensors
- Advanced Chemical Sensor Technologies
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Ministry of Agriculture and Rural Affairs
2025
Zhongnan Hospital of Wuhan University
2015-2024
Wuhan University
2015-2024
Soochow University
2024
Soochow University
2024
Peking University Shenzhen Hospital
2024
State Forestry and Grassland Administration
2015-2023
This study aims to explore the indicators for severity of coronavirus disease 2019 (COVID-19) in young patients between ages 18 and 40 years.This retrospective cohort included 65 consecutively admitted with COVID-19 who were years old Zhongnan Hospital Wuhan University Wuhan, China. Among them, 53 moderate cases, 12 severe or critical cases. Epidemiological, clinical, laboratory characteristics treatment data collected. A multivariate logistic regression analysis was implemented risk...
The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly among Chinese adults, and limited data are available on T2DM management the status glycemic control in China. We assessed efficacy oral antidiabetes drugs (OADs), glucagon-like peptide-1 (GLP-1) receptor agonists, insulin for treatment across multiple regions This was a multicenter, cross-sectional survey outpatients conducted 606 hospitals Data from all patients were collected between April June, 2011. A total 238,639...
Abstract Cancer-associated cachexia is a multi-organ weight loss syndrome, especially with wasting disorder of adipose tissue and skeletal muscle. Small extracellular vesicles (sEVs) serve as emerging messengers to connect primary tumour metabolic organs exert systemic regulation. However, whether how tumour-derived sEVs regulate white (WAT) browning fat poorly defined. Here, we report breast cancer cell-secreted exosomal miR-204-5p induces hypoxia-inducible factor 1A (HIF1A) in WAT by...
BACKGROUND Gestational diabetes mellitus (GDM) is common all over the world. GDM women are with inflammatory and metabolisms abnormalities. However, few studies have focused on association of IL-65-72C/G TNF-α -857C/T single nucleotide polymorphisms (SNPs), biomarkers, metabolic indexes in GDM, especially Inner Mongolia population. The aim this study was to investigate associations SNPs, inflammation biomarkers pregnancies. MATERIAL AND METHODS Blood samples placentas from 140 healthy...
H5N6 avian influenza viruses (AIVs) may pose a potential human risk as suggested by the first documented naturally-acquired virus infection in 2014. Here, we report cases of fatal (AIV) domestic cat and wild birds. These followed infections China preceded an outbreak chickens. The extensive migration routes birds contribute to geographic spread AIVs humans susceptible domesticated animals, from southern northern Additional surveillance is required better understand threat zoonotic transmission AIVs.
BACKGROUND:The aim of this study was to determine the effect C-reactive protein (CRP), lymphocytes (LYM), and ratio CRP LYM (CRP/LYM) on assessing prognosis COVID-19 severity at early stages disease. MATERIAL AND METHODS:A total 108 hospitalized patients diagnosed with in Zhongnan Hospital Wuhan University from January 17, 2020 March 12, were enrolled. Data demographic parameters, clinical characteristics, laboratory indicators, manifestation, outcome disease collected. The divided into a...
Chiglitazar (Carfloglitazar) is a novel non-thiazolidinedione (TZD) structured peroxisome proliferator-activated receptor (PPAR) pan-agonist that has shown promising effects on glycemic control and lipid regulation in patients with type 2 diabetes previous clinical studies. This randomized phase 3 trial aimed to compare the efficacy safety of chiglitazar placebo insufficient by strict diet exercise alone. Eligible were randomly assigned receive 32 mg (n = 167), 48 166), or 202) once daily....
Background The relationship between serum uric acid (SUA) and several diabetic complications or co-morbidities remains a matter of debate. study aims to explore the association SUA levels prevalence non-alcoholic fatty liver disease (NAFLD), retinopathy (DR), nephropathy (DN) peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM). Methods A total 2,809 participants (1,784 males 1,025 females) were included this cross-sectional study. Clinical characteristics each four...
Diabetic kidney disease (DKD) is a devastating complication of diabetes mellitus (DM) and the most prevalent chronic (CKD). Poricoic acid A (PAA), component isolated from Traditional Chinese Medicine (TCM) Poria cocos, has hypoglycaemic anti-fibrosis effects. However, role PAA in DKD remains largely unclear. To mimics an vitro model DKD, mouse podocyte MPC5 cells were treated with high glucose (25 mM; HG) for 24 h. CCK-8 flow cytometry assays conducted assessing cell viability apoptosis....
Abstract The triglyceride glucose (TyG) index has been confirmed a predictive value for type 2 diabetes mellitus (T2DM). However, no research yet whether there is linear correlation between the TyG and MACCEs in DFUs. present study aimed to delve into association risk of patients with A total 960 inpatients DFUs were recruited. All participants followed up every 6 months 11 years median 83 months. According cut‐off acquired from receiver operating characteristic (ROC) analysis, subjects...
Diabetic nephropathy (DN) is a severe renal disorder characterized by podocyte damage and accumulation of extracellular matrix leading to further glomerulosclerosis, possibly via the activation inflammatory signaling generation oxidative stress. Melatonin has been considered robust anti‑oxidant, able attenuate DN in several animal models. In present study, cell viability was examined CCK-8 assay. Cell apoptosis, intracellular reactive oxygen species mitochondrial membrane potential (MMP)...
Glucose and fatty acids play essential physiological roles in nearly all living organisms, the pathway that converts glucose into acid is pivotal to central metabolic network. We have successfully reconstituted a vitro using 30 purified proteins. Through systematic titration optimization of glycolytic pyruvate dehydrogenase, we increased yield free from nondetectable level exceeded 9% theoretical yield. also entire pentose-phosphate Escherichia coli established pentose phosphate-glycolysis...
Background and Objective Human beta‐defensins ( hBD s) are a group of antimicrobial peptides important in epithelial innate immunity, their differential expression is associated with periodontal diseases. The aim this study was to explore relationships among s, total subgingival bacteria periodontopathogens healthy subjects patients chronic periodontitis. Material Methods clinical parameters 29 25 periodontitis were recorded. relative 1 , hBD2 hBD3 genes gingival biopsies measured using...
Improving the early prediction and detection of diabetic nephropathy (DN) remains a great challenge in disease management. The aim this study was to evaluate power urinary vitamin D‑binding protein (VDBP) for diagnosis DN. Urine samples were obtained from 45 healthy volunteers 105 patients with normoalbuminuria (DM group), microalbuminuria (DN1 group) macroalbuminuria (DN2 (n=35 per group). VDBP expression patterns urine controls quantified by western blot analysis. excretion levels...
To describe the phenotypes associated with laser-induced retinal damage in children.Five patients maculopathy and reduced visual acuity laser pointer use were evaluated. Best-corrected acuity, structure, function monitored color fundus, infrared (IR), red-free images, fundus autofluorescence (AF), spectral domain-optical coherence tomography (SD-OCT), full-field electroretinography (ERG).All five injury had lesions resembling a macular dystrophy (one bilateral four unilateral). These...