A5033645349- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Connexins and lens biology
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Heme Oxygenase-1 and Carbon Monoxide
- Tissue Engineering and Regenerative Medicine
- Neurological Disease Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Paleontology and Evolutionary Biology
- Ichthyology and Marine Biology
- Acupuncture Treatment Research Studies
- Retinal Diseases and Treatments
- Asthma and respiratory diseases
- Neurological Disorders and Treatments
- Avian ecology and behavior
- Tumors and Oncological Cases
- Ocular Oncology and Treatments
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Bone Tissue Engineering Materials
- Ocular Infections and Treatments
- Dental Implant Techniques and Outcomes
- Venous Thromboembolism Diagnosis and Management
Fudan University
2020-2025
University of Auckland
2015-2025
Zhongshan Hospital
2019-2025
Guangxi Institute of Botany
2025
Chinese Academy of Sciences
2025
Le Bonheur Children's Hospital
2013-2024
Beijing Luhe Hospital Affiliated to Capital Medical University
2024
Chinese PLA General Hospital
2024
University of Tennessee Health Science Center
2013-2024
Beijing Children’s Hospital
2021-2023
Leukocyte adhesion to the vascular endothelium and subsequent transendothelial migration play essential roles in pathogenesis of cardiovascular diseases such as atherosclerosis. The leukocyte is mediated by localized activation through action inflammatory cytokines. exact proinflammatory factors, however, that activate their cellular sources remain incompletely defined.Using bone marrow-derived mast cells from wild-type, Tnf(-/-), Ifng(-/-), Il6(-/-) mice, we demonstrated all three these...
Connexin43 gap junction protein is expressed in astrocytes and the vascular endothelium central nervous system. It upregulated following system injury recognized as playing an important role modulating extent of damage. Studies that have transiently blocked connexin43 spinal cord epileptic models reported neuronal rescue. The purpose this study was to investigate rescue retinal ischaemia-reperfusion by blocking activity using a mimetic peptide. A further aim evaluate effect on permeability...
Abstract Sepsis‐induced immunosuppression is related to increased susceptibility secondary infections and death. Lung the most vulnerable target organ in sepsis, but understanding of pulmonary state still limited. Here, single‐cell RNA sequencing bronchoalveolar lavage fluid (BALF) performed map landscape immune cells, revealing a neutrophil‐driven immunosuppressive program lungs patients with sepsis. Although genes are upregulated different only neutrophils dramatically increase BALF phase...
BACKGROUND Gestational diabetes mellitus (GDM) is common all over the world. GDM women are with inflammatory and metabolisms abnormalities. However, few studies have focused on association of IL-65-72C/G TNF-α -857C/T single nucleotide polymorphisms (SNPs), biomarkers, metabolic indexes in GDM, especially Inner Mongolia population. The aim this study was to investigate associations SNPs, inflammation biomarkers pregnancies. MATERIAL AND METHODS Blood samples placentas from 140 healthy...
Abstract Stroke is the most frequent cause of secondary epilepsy in elderly. The incidence cerebral stroke increasing with extension life expectancy, and prevalence post-stroke (PSE) rising. There are various seizure types after stroke, occurrence closely related to type location stroke. Moreover, clinical treatment difficult, which increases risk disability death, affects prognosis quality patients. Now more get attention medical profession, has been researchers have devoted seizures PSE...
Globally millions are blind due to corneal disease, yet tissue for transplantation is a limited resource. This study characterizes the physical and biological properties of novel collagen-based scaffold. Transparency, optical coherence tomography (OCT), scanning electron microscopy (SEM) were used analyze structure scaffold, synthesized using rat tail collagen I. Water content was determined. The tensile strength assessed micro-mechanical analyzer. In vitro biocompatibility by culturing...
MicroRNAs (miRNAs) have been reported to circulate in the blood a highly stable and cell-free form. Dysregulated expression of miRNAs has detected various pathological conditions including atopic dermatitis. In our study, human plasma were identified by high-throughput sequencing compared among patients dermatitis healthy controls. We found that miR-151a was differentially expressed patients. MiR-151a regulates IL12RB2 targeting two loci 3' untranslated region Il12rb2 gene. Moreover,...
Diabetic retinopathy is a vascular disease of the retina characterised by hyperglycaemic and inflammatory processes. Most animal models diabetic are hyperglycaemia-only that do not account for significant role inflammation plays in development disease. In present study, we data on establishment new model incorporates both hyperglycaemia inflammation. We hypothesized may trigger worsen environment. Pro-inflammatory cytokines, IL-1β TNF-α, were therefore injected into vitreous non-obese (NOD)...
The immobilization of heparin, a new and versatile approach to the surface modification decellularized tissues, has potential greatly improve hemocompatibility engineered tissue constructs derived from organs. We report on porcine liver scaffolds (DLSs) heparinized by end-point attachment (EPA) technique. DLSs (HEP-DLSs) have ability bind slowly release heparin-binding growth factors. hypothesized that DLS-immobilized heparin acts as an antithrombotic coating reagent binds vascular...
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. The inflammatory cytokine storm causes systemic damage, especially acute lung injury in sepsis. In this study, we found that the expression of S-phase kinase-associated protein 2 (Skp2) was significantly decreased sepsis-induced (ALI). activated MEK/ERK pathway and inhibited Skp2 pulmonary epithelium, resulting reduction K48 ubiquitination solute carrier family 3 member (SLC3A2), thereby...