A5072456259- Immune cells in cancer
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Viral-associated cancers and disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Solar Radiation and Photovoltaics
- Atherosclerosis and Cardiovascular Diseases
- Extracellular vesicles in disease
- Environmental DNA in Biodiversity Studies
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Advanced Algorithms and Applications
- Inflammatory Bowel Disease
- Histone Deacetylase Inhibitors Research
- Wind Energy Research and Development
- Acute Lymphoblastic Leukemia research
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 and COVID-19 Research
- Bone Metabolism and Diseases
- HVDC Systems and Fault Protection
- Retinal Diseases and Treatments
Center for Life Sciences
2023-2025
Southern Medical University
2025
Zhujiang Hospital
2025
Guangxi Academy of Sciences
2023-2025
Guangxi Medical University
2024
California Liver Research Institute
2023
Qingdao University
2023
Cell Technology (China)
2023
Yuhuangding Hospital
2023
University of Hong Kong
2017
Lung adenocarcinoma (LUAD) is a common type of lung cancer with high risk metastasis, but the exact molecular mechanisms metastasis are not yet understood.This study acquired single-cell transcriptomics profiling 11 distal normal tissues, primary LUAD and 4 metastatic tissues from GSE131907 dataset. The multicellular ecosystems were characterized at resolution, potential underlying angiogenesis explored.We constructed global landscape 93,610 cells found that IGF2BP2 was specifically...
Abstract In metabarcoding research, such as taxon identification, phylogenetic placement plays a critical role. However, many existing methods lack comprehensive features for downstream analysis and visualization. Visualization tools often ignore uncertainty, making it difficult to explore interpret data effectively. To overcome these limitations, we introduce scalable approach using treeio ggtree parsing visualizing data. The ‐ method supports filtration, uncertainty exploration, customized...
Abstract Sepsis‐induced immunosuppression is related to increased susceptibility secondary infections and death. Lung the most vulnerable target organ in sepsis, but understanding of pulmonary state still limited. Here, single‐cell RNA sequencing bronchoalveolar lavage fluid (BALF) performed map landscape immune cells, revealing a neutrophil‐driven immunosuppressive program lungs patients with sepsis. Although genes are upregulated different only neutrophils dramatically increase BALF phase...
Both environmental and genetic factors contribute to the etiology of autoimmune thyroid disease (AITD) including Graves' (GD) Hashimoto's thyroiditis (HT). However, exact pathogenesis interactions that occur between genes remain unclear, therapeutic targets require further investigation due limited options. To solve such problems, this study utilized single-cell transcriptome, whole full-length transcriptome (Oxford nanopore technology), metabolome sequencing examine lesion tissues from 2 HT...
In recent years, the global incidence of myopia has steadily increased, highlighting importance prevention and early intervention, particularly in absence effective treatments. Here, we identified a previously unreported mutation human N-acetylated alpha-linked acidic dipeptidase 2 (NAALAD2) gene (c.2109T>G, p.F703L) considered Chinese family with pathological (PM). We explored potential link between NAALAD2 development PM by using Naalad2 point knock-in mouse models. Through single-cell RNA...
With the aging of population, incidence osteoporosis (OP) is on rise, but ecology immune cell subpopulations in OP poorly understood. Therefore, identifying involved promoting development may facilitate new treatments. Based bioinformatics analysis, we constructed a single-cell landscape microenvironment and identified to further explore role different abnormal bone microenvironment. Among macrophages (Mac), Mac_OLR1 subpopulation has an M1-like phenotype significantly activates cytokine...
Bone metastasis (BM) is one of the main manifestations advanced breast cancer (BC), causing complications such as pathological fractures, which seriously affects quality life patients and even leads to death. In our study, a global single-cell landscape tumor microenvironment was constructed using single cell RNA sequencing data from BM. BC cells were found be reduced in BM, while mesenchymal stem (MSCs), Fibroblasts other significantly more abundant The subpopulations these further...
Aim: Study the correlation of expression genes involved in cytarabine metabolism to leukemia-free (LFS) and overall survival (OS) AML. Introduction: Cytarabine is backbone AML therapy. Understanding roles polymorphisms resistance will facilitate development novel therapeutics. Methods: Adults less than 60 years with non M3 were included. Archived diagnostic marrow samples studied for 10 by RT-qPCR; gene normalized GAPDH was compared using unpaired t-test Welch correction. SNP rs4694362...