A5026192475- Bone Metabolism and Diseases
- Bone health and treatments
- Bone and Dental Protein Studies
- Nutrition, Genetics, and Disease
- interferon and immune responses
- Species Distribution and Climate Change
- Nanoparticle-Based Drug Delivery
- Skin Protection and Aging
- Bone health and osteoporosis research
- Electrospun Nanofibers in Biomedical Applications
- Genomics and Phylogenetic Studies
- Micro and Nano Robotics
- Osteoarthritis Treatment and Mechanisms
- Facial Trauma and Fracture Management
- Cytokine Signaling Pathways and Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Bone Tissue Engineering Materials
- Vitamin K Research Studies
- Intraperitoneal and Appendiceal Malignancies
- Silk-based biomaterials and applications
- Telomeres, Telomerase, and Senescence
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Antioxidants, Aging, Portulaca oleracea
Southern Medical University
2021-2025
Chinese PLA General Hospital
2025
Third Affiliated Hospital of Southern Medical University
2019-2023
Abstract In metabarcoding research, such as taxon identification, phylogenetic placement plays a critical role. However, many existing methods lack comprehensive features for downstream analysis and visualization. Visualization tools often ignore uncertainty, making it difficult to explore interpret data effectively. To overcome these limitations, we introduce scalable approach using treeio ggtree parsing visualizing data. The ‐ method supports filtration, uncertainty exploration, customized...
Abnormal subchondral bone remodeling plays a pivotal role in the progression of osteoarthritis (OA). Here, we analyzed samples from OA patients and observed significant upregulation ubiquitin carboxy-terminal hydrolase L1 (UCHL1) specifically osteoclasts. Notably, found strong correlation between UCHL1 expression osteoclast activity during both human murine models. Conditional deletion precursors exacerbated progression, while its overexpression, mediated by adeno-associated virus 9,...
The C-X-C motif chemokine ligand 2 (CXCL2), a member of the CXC receptor family, is involved in various immune and inflammatory processes, but its effect(s) on bone formation have not yet been reported. We report here that CXCL2 enriched marrow show abundant expression osteoblasts osteoporotic mice. neutralization within by using antibody alleviated loss mice, indicating negative role formation. In line with this, overexpression attenuated proliferation, as well differentiation, vitro By...
Senescence impairs preosteoblast expansion and differentiation into functional osteoblasts, blunts their responses to bone formation-stimulating factors stimulates secretion of osteoclast-activating factors. Due these adverse effects, senescence is a crucial target for the treatment age-related loss; however, underlying mechanism remains unclear. We found that mTORC1 accelerated in vitro mouse model. Mechanistically, induced change membrane potential from polarization depolarization, thus...
The application of chitosan nanofibers in biological tissue-engineering materials has attracted wide attention. A novel and organic solvent-free method was developed for the fabrication rootlike (CSNFs) with diameters 40–250 nm. This includes three-step mechanical processing swelling–beating-centrifugation or swelling–beating–homogenization. obtained showed high yields (>95%) positive specific surface charges (up to +375 μeq/g) could be uniformly dispersed aqueous phase. unique fiber shape...
Estrogen deficiency leads to bone loss in postmenopausal osteoporosis, because formation, albeit enhanced, fails keep pace with the stimulated osteoclastic resorption. The mechanism driving this uncoupling is central pathogenesis of which, however, remains poorly understood. We previously found that Cxcl9 secreted by osteoblasts inhibited osteogenesis bone, while roles on resorption and osteoporosis are unclear.Postmenopausal mouse model was established bilateral surgical ovariectomy (OVX)....
Although clinical evidence has indicated an association between skin atrophy and bone loss during ageing, their causal relationship the underlying mechanisms are unknown. Here we show that premature ageing drives age-related in mice. We further identify cystatin-A (Csta), a keratinocyte-enriched secreted factor, mediates effect of on bone. Keratinocyte-derived Csta binds receptor for activated C-kinase 1 (Rack1) osteoblast osteoclast progenitors, thus promoting proliferation, but inhibiting...