A5009587339- Extracellular vesicles in disease
- Bone Metabolism and Diseases
- Telomeres, Telomerase, and Senescence
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Bone and Dental Protein Studies
- Renal cell carcinoma treatment
- Nanoplatforms for cancer theranostics
- Genetics and Neurodevelopmental Disorders
- Kruppel-like factors research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- T-cell and B-cell Immunology
- Photodynamic Therapy Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- interferon and immune responses
- Viral Infections and Vectors
- Photoacoustic and Ultrasonic Imaging
- CAR-T cell therapy research
- Advancements in Transdermal Drug Delivery
- RNA Research and Splicing
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
Mengchao Hepatobiliary Hospital
2022-2025
Fujian Medical University
2022-2025
Third Affiliated Hospital of Southern Medical University
2020-2025
Southern Medical University
2021-2025
Fuzhou University
2025
Tongji University
2023-2024
Xuzhou Medical College
2023
The First People’s Hospital of Lianyungang
2023
Shanghai Jiao Tong University
2023
Bridge University
2023
Abstract Osteoarthritis (OA) is marked by cartilage deterioration, subchondral bone changes, and an inflammatory microenvironment. The study introduces the Microneedle‐Delivered Polydopamine‐Exosome (PDA@Exo MN), a therapeutic that not only preserves promotes regeneration but also improves localized drug delivery through enhanced penetration capabilities. PDA@Exo MN shows strong reactive oxygen species (ROS) scavenging abilities high biocompatibility, fostering osteogenesis balancing...
Bone marrow-derived mesenchymal stem cells (BMSCs) tend to differentiate into adipocytes rather than osteoblasts in osteoporosis and other pathological conditions. Understanding the mechanisms underlying adipo-osteogenic imbalance greatly contributes ability induce specific MSC differentiation for clinical applications. This study aimed explore whether DEP-domain containing mTOR-interacting protein (DEPTOR) regulated fate bone-fat switch, which was indicated be a key player bone homeostasis....
Abstract Hypoxia‐associated radioresistance in rectal cancer (RC) has severely hampered the response to radioimmunotherapy (iRT), necessitating innovative strategies enhance RC radiosensitivity and improve iRT efficacy. Here, a catalytic radiosensitizer, DMPtNPS, STING agonist, cGAMP, are integrated overcome iRT. DMPtNPS promotes efficient X‐ray energy transfer generate reactive oxygen species, while alleviating hypoxia within tumors, thereby increasing radiosensitivity. Mechanistically,...
Rationale: Although neoantigen-based cancer vaccines have shown promise in various solid tumors, limited immune responses and clinical outcomes been reported patients with advanced disease.Cytosolic transport of neoantigen adjuvant is required for the activation intracellular Toll-like receptors (TLRs) cross-presentation to prime neoantigen-specific CD8 + T cells but remains a significant challenge.Methods: In this study, we aimed develop virus-like silicon vaccine (V-scVLPs) unique spike...
Rationale: Immuno-virotherapy has emerged as a promising approach for cancer treatment, it directly and cytotoxically eliminates tumors with systemic immune stimulation. However, the clinical efficacy of this remains limited by inappropriate delivery routes, robust antiviral responses, tumor immunosuppressive microenvironment. Methods: To address these challenges, we propose surface engineering strategy that masks oncolytic herpes simplex virus (oHSV) galactose-polyethylene-glycol (PEG)...
Senescence impairs preosteoblast expansion and differentiation into functional osteoblasts, blunts their responses to bone formation-stimulating factors stimulates secretion of osteoclast-activating factors. Due these adverse effects, senescence is a crucial target for the treatment age-related loss; however, underlying mechanism remains unclear. We found that mTORC1 accelerated in vitro mouse model. Mechanistically, induced change membrane potential from polarization depolarization, thus...
Abstract Osteosarcoma (OS), the most common primary bone tumor in children and young adults, poses significant clinical challenges. In this study, we investigated role of exosomes—key mediators intercellular communication—in OS progression identified potential therapeutic targets. Functional assays cellular animal models demonstrated that OS‐derived exosomes markedly enhanced proliferation, migration, invasion. Data‐independent acquisition‐based mass spectrometry analysis revealed a notable...
X-ray-induced photodynamic therapy offers substantial promise for treating deep-seated tumors, but it is still limited by highly inefficient energy transfer processes and the stringent requirements scintillators with high luminescence quantum yield significant singlet-triplet intersystem crossing ratios. Herein, we describe electron-dynamic (X-eDT), which obviates need exposing nonluminescent hafnium-silica nanoparticles to X-rays, generate high-energy electrons that can sensitize...
Purpose: This study aimed to assess the efficacy and safety of adjuvant transarterial chemoembolization (TACE) plus tyrosine kinase inhibitor (TKI) treatment in patients with hepatocellular carcinoma (HCC) a high risk early recurrence after curative resection. Patients Methods: from multiple centres were divided into postoperative TACE (n=57) or without (n=142) TKI administration groups. The disease-free survival (DFS) curve was depicted by Kaplan–Meier method, difference between two groups...
Estrogen deficiency leads to bone loss in postmenopausal osteoporosis, because formation, albeit enhanced, fails keep pace with the stimulated osteoclastic resorption. The mechanism driving this uncoupling is central pathogenesis of which, however, remains poorly understood. We previously found that Cxcl9 secreted by osteoblasts inhibited osteogenesis bone, while roles on resorption and osteoporosis are unclear.Postmenopausal mouse model was established bilateral surgical ovariectomy (OVX)....
<title>Abstract</title> <bold>Background</bold> Osteosarcoma (OS) stands as the predominant primary bone tumor impacting children and young adults. Exosomes, vital for cellular communication, emerge promising markers diagnosing prognosticating tumors. While few proteomic studies have delved into osteosarcoma's exosomal protein secretion, examining differences in proteomes from OS cells can unveil insights development spread. <bold>Methods </bold>This investigation employed Data-Independent...
Tyrosine kinase inhibitors (TKIs) and anti-PD-1 antibodies in combination provide survival benefits for patients with unresectable hepatocellular carcinoma (uHCC). However, the tool used to determine which likely benefit most from this treatment strategy has not been reported. We sought develop a prognostic scoring system based on tumor burden score (TBS) alpha-fetoprotein (AFP) predict long-term prognosis of uHCC treated TKIs antibodies. Data multiple centers were collected. The accuracy...
Abstract In osteosarcoma, the efficacy of immune-checkpoint blockade immunotherapy is hindered by low immunogenicity and limited T-cell infiltration thus, triggering robust antitumor immune responses has become a pivotal goal in cancer therapy. Herein, we design novel approach to promote combining checkpoint therapy with newly developed nanoplatform for sonodynamic The study involved attachment Ce6 photosensitizer phenylboronic acid -based nanoparticles named NPs, which were encapsulated...
Abstract SARC (sarcoma) is a heterogeneous group of stromal tumors originating from mesenchymal tissues with poor prognosis. There growing evidence that senescent cells in the tumor microenvironments (TME) are associated development and metastasis cancer. The impact senescence on sarcomas has been initially recognized, but not fully understood. Here, we revealed level age were both TME, immune treatment indicators prognosis SARC. WGCNA least-selection absolute regression algorithm (LASSO)...
Although clinical evidence has indicated an association between skin atrophy and bone loss during ageing, their causal relationship the underlying mechanisms are unknown. Here we show that premature ageing drives age-related in mice. We further identify cystatin-A (Csta), a keratinocyte-enriched secreted factor, mediates effect of on bone. Keratinocyte-derived Csta binds receptor for activated C-kinase 1 (Rack1) osteoblast osteoclast progenitors, thus promoting proliferation, but inhibiting...