A5101567372- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Photosynthetic Processes and Mechanisms
- Single-cell and spatial transcriptomics
- Lower Extremity Biomechanics and Pathologies
- Orthopedic Infections and Treatments
- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
- Biochemical and biochemical processes
- Knee injuries and reconstruction techniques
- Sarcoma Diagnosis and Treatment
- Plant biochemistry and biosynthesis
- Extracellular vesicles in disease
- Gut microbiota and health
- Nerve Injury and Rehabilitation
- SARS-CoV-2 detection and testing
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Health, Environment, Cognitive Aging
- Crop Yield and Soil Fertility
- Blood transfusion and management
- Shoulder and Clavicle Injuries
- Biosensors and Analytical Detection
- RNA Research and Splicing
- Plant Parasitism and Resistance
Shanghai Jiao Tong University
2025
Changchun University of Chinese Medicine
2016-2025
Shanghai Tenth People's Hospital
2015-2024
Tongji University
2017-2024
La Jolla Bioengineering Institute
2024
University of California, San Diego
2022-2024
Yunnan Academy of Agricultural Sciences
2020-2023
Wenshan University
2022
China Tobacco
2020-2021
Yunnan Agricultural University
2009-2020
Osteoarthritis (OA) is characterized by cartilage degradation and subchondral bone remodeling. However, most available studies focus on either or lesion, alone, rarely pay attention to the synergy of these two pathological changes. Herein, a dual-functional medication developed simultaneously protect achieve repair. Black phosphorus nanosheets (BPNSs), with strong reactive oxygen species (ROS)-scavenging capability high biocompatibility, also present notable promoting effect in osteogenesis....
Abstract Osteosarcoma is one of the most dreadful bone neoplasms in young people, necessitating development innovative therapies that can effectively eliminate tumors while minimizing damage to limb function. An ideal therapeutic strategy should possess three essential capabilities: antitumor effects, tissue‐protective properties, and ability enhance osteogenesis. In this study, self‐assembled Ce‐substituted molybdenum blue (CMB) nanowheel crystals are synthesized loaded onto 3D‐printed...
Abstract Osteoarthritis (OA) is marked by cartilage deterioration, subchondral bone changes, and an inflammatory microenvironment. The study introduces the Microneedle‐Delivered Polydopamine‐Exosome (PDA@Exo MN), a therapeutic that not only preserves promotes regeneration but also improves localized drug delivery through enhanced penetration capabilities. PDA@Exo MN shows strong reactive oxygen species (ROS) scavenging abilities high biocompatibility, fostering osteogenesis balancing...
Background: The aim of the study was to compare clinical outcomes patients undergoing all-arthroscopic (AA) or mini-open (MO) rotator cuff repair. Methods: present evaluated 50 who had undergone AA repair and MO with a minimum 1-year follow-up. Every patient asked complete Disabilities Arm, Shoulder Hand (DASH) visual analog scale (VAS) questionnaires. Constant–Murley score (CMS) active ranges, forward flexion external rotation, were also documented. One year after surgery, ultrasound...
Osteosarcoma (OS), the most common bone cancer, causes high morbidity in children and young adults. TRIM46 is a member of family tripartite motif (TRIM)-containing proteins that serve as important regulators tumorigenesis. Here we investigate possible role OS underlying molecular mechanism. We report an increase expression its association with tumor size, Ennekings stage, patient prognosis. knockdown inhibits cell viability cycle progression induces apoptosis, while overexpression exerts...
Abstract The composition and content of aroma substances in flue-cured tobacco ( Nicotiana tabacum L.) will affect the quality tobacco. To investigate correlation between various K326 before after flue-curing, their impact on diversity, this study employed middle leaves KRK26 as test materials. Samples were collected both flue-curing for untargeted metabolomics analysis. results showed that 584 metabolites significantly different there 44 aroma-related metabolites, including alcohols,...
Background Corona Virus Disease 2019 (COVID-19) and Osteoarthritis (OA) are diseases that seriously affect the physical mental health life quality of patients, particularly elderly patients. However, association between COVID-19 osteoarthritis at genetic level has not been investigated. This study is intended to analyze pathogenesis shared by OA identify drugs could be used treat SARS-CoV-2-infected Methods The four datasets (GSE114007, GSE55235, GSE147507, GSE17111) for analysis in this...
Abstract Osteosarcoma, recognized for its aggressiveness and resistance to chemotherapy, notably doxorubicin, poses significant treatment challenges. This comprehensive study investigated the CXCR4–CARM1–YAP signaling axis pivotal function in controlling aerobic glycolysis, which plays a crucial role doxorubicin resistance. Detailed analysis of Dox‐resistant 143b/MG63‐DoxR cells has uncovered overexpression CXCR4. Utilizing combination molecular biology techniques including gene silencing,...
Morphologic measurements of the femoral and tibial features western population have been done in several studies, which provides fundamental data for design total knee arthroplasty prosthesis used globally, including China. However, researches on anatomic morphologic Chinese populations both sexes never conducted. Our study was aimed at investigating knees Southeastern by magnetic resonance imaging (MRI) scans, so as to provide parameters sex- ethnic-specific implant designs future.A 245...
Recent studies show that lncRNAs involve in the initiation and progression of various cancers including osteosarcoma (OS). IncRNA Xist has been verified as an oncogene several human cancers, its abnormal expression was closely associated with tumor progression. Nevertheless, role OS remains unclear. Here, we revealed level up-regulated tissues discovered knockdown significantly repressed cell proliferation. Additionally, mechanistic analysis can repress P21 to regulate cycle proliferation by...
Pseudolaric acid B (PAB) has been demonstrated to exert antitumor effects in MCF-7 human breast cancer cells. The present study aimed investigate the mechanism of resistance PAB-induced cell death. Following incubation with 4 µM PAB for 3 days, majority cells became senescent, while some retained same morphology as control cells, assessed using a senescence detection kit. Additionally, 36 h treatment increased positive staining autophagy markers, shown by monodansylcadaverine and acridine...
An amendment to this paper has been published and can be accessed via the original article.
Abstract Background This randomized controlled study compared standard supervised physiotherapy (SPT) with a self-developed, home-based, enhanced knee flexion exercise program involving low stool (KFEH) in patients who underwent total arthroplasty (TKA). Methods Patients were recruited from July 2014 to December 2015 and randomly assigned one of two groups: KFEH ( n = 60) SPT 59). Outcomes (joint function) evaluated according the Knee Society Score (KSS), visual analog scale (VAS), Western...
Background: The gut microbiota is associated with osteoarthritis (OA) progression. Miya (MY) a product made from Clostridium butyricum, member of microbiota. This study was conducted to investigate the effects MY on OA and its underlying mechanisms. Methods: An rat model established, used treat rats for 4 weeks. Knee joint samples were stained hematoxylin-eosin, fecal OA+MY groups subjected 16S rDNA sequencing metabolomic analysis. contents succinate dehydrogenase muscle glycogen in tibia...
Abstract BACKGROUND Our objective in this study was to evaluate the effectiveness of oligosaccharides extracted from black ginseng (OSBG), innovatively prepared by a low‐temperature steam‐heating process, improvement learning and memory impairment mice, as well mechanism(s). RESULTS Eight carbohydrates involving isomaltose maltotetraose were detected gensing; monosaccharide residues including mannose rhamnose also discovered. OSBG‐treated mice showed significant amelioration recognition...