A5048718343- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Cystic Fibrosis Research Advances
- Infectious Diseases and Tuberculosis
- Total Knee Arthroplasty Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Pleural and Pulmonary Diseases
- Neonatal Respiratory Health Research
- Marine Bivalve and Aquaculture Studies
- Lung Cancer Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Marine and fisheries research
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Dental Anxiety and Anesthesia Techniques
- Immune Cell Function and Interaction
- Orthopedic Infections and Treatments
- RNA modifications and cancer
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Aquaculture Nutrition and Growth
- Amoebic Infections and Treatments
National Taiwan University Hospital
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2019-2024
Chongqing Medical University
2019-2024
Shanghai Pulmonary Hospital
2015-2024
Tongji University
2015-2024
Shanghai Clinical Research Center
2021-2024
Novartis (United States)
2024
Stomatological Hospital of Chongqing Medical University
2021-2024
Second Affiliated Hospital of Nanjing Medical University
2024
Shandong University
2024
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage lobe-finned fish thought to have become extinct 70 million years ago. modern looks remarkably similar many its ancient relatives, and evolutionary proximity our own ancestors provides glimpse the that first walked on land. Here we report genome sequence African coelacanth, Latimeria chalumnae. Through phylogenomic analysis, conclude lungfish, not is closest relative tetrapods. Coelacanth protein-coding...
Renal ischemia/reperfusion (I/R) injury is the main reason for acute kidney (AKI) and closely related to high morbidity mortality. In this study, we found that exosomes from human-bone-marrow-derived mesenchymal stem cells (hBMSC-Exos) play a protective role in hypoxia/reoxygenation (H/R) injury. hBMSC-Exos were enriched miR-199a-3p, hBMSC-Exo treatment increased expression level of miR-199a-3p renal cells. We further explored function on H/R was knocked down hBMSCs with inhibitor. HK-2...
Tumour‑associated macrophages (TAMs) compose a major component of the tumour microenvironment and form in this prior to cancer metastasis. However, detailed mechanisms TAM remodelling context bladder have not been clearly defined. The present study collected exosomes from conditioned medium human T24 cells. effects treated with derived cells on cell migration invasion were analysed by Transwell assays. expression levels endogenous exosomal microRNA‑21 (miR‑21) examined reverse...
Abstract The role of the PD-1/PD-L pathway in a murine model tuberculosis remains controversial regarding viral infections and clinical tuberculosis. We conducted case-control study to investigate modulating mechanism patients with active Fifty-nine participants, including 43 (ATB) 16 healthy controls (HC), were enrolled. Cell surface staining flow cytometry used detect expressions PD-1 its ligands on T cells monocytes. Intracellular cytokine was determine PPD-specific IFN-γ-secreting T-cell...
Cystic fibrosis is realizing the promise of personalized medicine.Recent advances in drug development that target causal CFTR directly result lung function improvement, but variability response demanding better prediction outcomes to improve management decisions.The genetic modifier SLC26A9 contributes disease severity CF pancreas and intestine at birth here we assess its relationship with therapeutic airways.SLC26A9 association was assessed individuals from Canadian French Gene Modifier...
Bone marrow–derived mesenchymal stem cells (BMSCs) have been recently reported to play a variety of vital roles in organ and tissue damage repair, mainly via potent paracrine activity, including secreting extracellular vesicles, such as exosomes, that serve mediators facilitating intercellular communication reprogramming recipient by delivering their contents target cells. However, the underlying mechanisms are diverse complex, influencing characteristics rarely studied. Accordingly, we...
To evaluate the diagnostic performance of Xpert MTB/RIF Ultra for EPTB (Extrapulmonary Tuberculosis) patients on different types extrapulmonary specimens from anatomic sites.Patients with suspected were prospectively included, collected and subjected to culture, assays in accordance relevant guidelines.A total 225 cases included which contained 200 (43 culture-positive EPTB, 157 culture-negative diagnosed based pathological results a satisfied response anti-TB treatment) 25 non-EPTB cases....
Cystic Fibrosis (CF) exhibits morbidity in several organs, including progressive lung disease all patients and intestinal obstruction at birth (meconium ileus) ~15%. Individuals with the same causal CFTR mutations show variable presentation which is partly attributed to modifier genes. With >6,500 participants from International CF Gene Modifier Consortium, genome-wide association investigation identified a new locus for meconium ileus encompassing ATP12A on chromosome 13 (min p =...
Metagenomic Next-Generation Sequencing (mNGS) has been applied as a novel method of detection pathogens for infectious diseases, but its value in the rapid diagnosis tuberculous meningitis(TBM)has not clarified based on large samples.A retrospective analysis was conducted 51 inpatients with suspected TBM who underwent mNGS and four other tests cerebrospinal fluid (CSF).Among included patients, 45 cases were diagnosed (38 definite, 5 probable, 2 possible) 6 non-TBM. Using final reference...
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), and remains a leading public health problem. Previous studies have identified host genetic factors that contribute to Mtb infection outcomes. However, much of the heritability in TB unaccounted for additional susceptibility loci most likely exist. We perform multistage genome-wide association study on 2949 pulmonary patients 5090 healthy controls (833 cases 1220 were genotyped) from Han Chinese population....
Due to the inherent characteristics of immersion, imagination, and interactivity in virtual reality (VR), it might be suitable for non-drug behavior management children dental clinics. The purpose this trial was measure role VR distraction on short-term procedures children.
Background: The aim of the study was to compare clinical outcomes patients undergoing all-arthroscopic (AA) or mini-open (MO) rotator cuff repair. Methods: present evaluated 50 who had undergone AA repair and MO with a minimum 1-year follow-up. Every patient asked complete Disabilities Arm, Shoulder Hand (DASH) visual analog scale (VAS) questionnaires. Constant–Murley score (CMS) active ranges, forward flexion external rotation, were also documented. One year after surgery, ultrasound...
In recent years, the number of people using mobile applications to promote health and welfare has exponentially increased. However, there are fewer in field ERAS. How rapid rehabilitation patients with malignant tumor surgery during perioperative period mastery its long-term nutritional state is a problem be solved.The purpose this study design develop application, use Internet technology better manage achieve recovery surgery.This divided into three stages: (1) Design: participating make...
The severity of intestinal disease associated with Cystic Fibrosis (CF) is variable in the patient population and this variability partially conferred by influence modifier genes. Genome-wide association studies have identified SLC6A14, an electrogenic amino acid transporter, as a genetic CF-associated meconium ileus. purpose current work was to determine biological role Slc6a14, disrupting its expression CF mice bearing major mutation, F508del. We found that disruption Slc6a14 worsened...