A5102783417- Renal Diseases and Glomerulopathies
- Telomeres, Telomerase, and Senescence
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammasome and immune disorders
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Vasculitis and related conditions
- Oral and Maxillofacial Pathology
- Genomics and Rare Diseases
- Nanoplatforms for cancer theranostics
- Retinal Development and Disorders
- Chronic Kidney Disease and Diabetes
- Retinoids in leukemia and cellular processes
- Sphingolipid Metabolism and Signaling
- Pharmacological Effects of Natural Compounds
- Aortic aneurysm repair treatments
- PI3K/AKT/mTOR signaling in cancer
- Congenital heart defects research
- Epigenetics and DNA Methylation
- Gastrointestinal motility and disorders
- Whipple's Disease and Interleukins
- Chemotherapy-induced organ toxicity mitigation
- Lipid metabolism and disorders
Nanjing Medical University
2022
State Key Laboratory of Oncogene and Related Genes
2019-2021
Renji Hospital
2017-2021
Shanghai Jiao Tong University
2008-2021
Shanghai Cancer Institute
2019-2021
Tongji University
2021
Shanghai Tenth People's Hospital
2021
Shanghai Sixth People's Hospital
2011-2020
Anhui Provincial Children's Hospital
2001-2019
Baylor College of Medicine
2010-2011
Abstract Hepatocellular carcinoma (HCC) is a malignancy with poor prognosis. Surgery combined chemotherapy has been recommended as curative regimen for HCC. Nevertheless, the anticancer mechanisms of chemicals in hepatocellular remain unclear. Pyroptosis type programmed necrosis, and its mechanism poorly understood. The efficacy arsenic trioxide nanoparticles treatment HCC were explored this research. Arsenic alone conveniently administered to mice intratumorally using needle. Compared As 2...
Abstract Background CircRNAs are found to affect initiation and progression of several cancer types. However, whether circRNAs implicated in gallbladder (GBC) remains obscure. Methods We perform RNA sequencing 10 pairs GBC para-cancer tissues. CCK8 clone formation assays used evaluate proliferation ability cells. qPCR Western blot determine expression RNAs proteins, respectively. CircRNA-protein interaction is confirmed by pulldown, immunoprecipitation, fluorescence situ hybridization....
Detection of low-affinity or transient interactions can be a bottleneck in our understanding signaling networks. To address this problem, we developed an arrayed screening strategy based on protein complementation to systematically investigate protein-protein live human cells, and performed large-scale screen for regulators telomeres. Maintenance vertebrate telomeres requires the concerted action members Telomere Interactome, built upon six core telomeric proteins TRF1, TRF2, RAP1, TIN2,...
Abstract Gallbladder cancer represents the most common malignancy of biliary tract and is highly lethal with less than 5% overall 5-year survival rate. Chemotherapy remains major treatment for late-stage patients. However, insensitivity to these chemotherapeutic agents including cisplatin common. MicroRNAs (miRNAs) have been shown as modulators drug resistance in many types. We used genome-wide gene expression analysis clinical samples identify miR-125b-5p down-regulated gallbladder cancer....
To explore the approaches and diagnostic yield of genetic testing for renal disease in children, we describe genotype phenotype national cohort children with from 13 different regions China recruited 2014 to 2018 by building up multicenter registration system (Chinese Children Genetic Kidney Disease Database, CCGKDD). diagnosis was confirmed 42.1% our 1001 pediatric patients clinical suspicion a disease. Of 106 distinct monogenetic disorders detected, 15 accounted 60.7% diagnoses. The 29.1%...
Dyskeratosis congenita (DC) is a progressive and heterogeneous congenital disorder that affects multiple systems characterized by bone marrow failure triad of abnormal skin pigmentation, nail dystrophy, oral leukoplakia. One common feature for all DC patients abnormally short telomeres defects in telomere biology. Most the known mutations have been found to affect core components telomerase holoenzyme. Recently, gene encoding telomeric protein TIN2 identified with intact genes, but molecular...
Abstract Complete blood blockage and low ectopic embolism risk are urgently needed for transcatheter arterial chemoembolization (TACE) treatment. However, the clinically available embolic reagents still face huge challenges of fast recanalization undesirable migration. In present work, a temperature‐sensitive poloxamer 407 (F127)/hydroxymethyl cellulose (HPMC)/sodium alginate (SA)‐derived hydrogel (FHSgel) is explored as novel material in TACE With increasing temperature, this FHSgel...
To explore the changes of inflammatory and oxidative stress responses in Henoch-Schönlein purpura (HSP) children, further analyzed therapeutic effects mechanisms hemoperfusion (HP) on HSP with severe gastrointestinal (GI) involvement.There were 200 children divided into three groups according to their clinical manifestations: 60 without GI renal involvement group, 80 HSPN group. The group was subdivided conventional treatment (n = 30) HP groups. Thirty who visited department healthcare for...
An amendment to this paper has been published and can be accessed via the original article.
We investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita, on doxorubicin- (DXR-) induced renal fibrosis in mice. The mice were pretreated for 7 days with DAL followed by single injection DXR (10 mg/kg) via tail vein. Renal function was analyzed 5 weeks after treatment. caused nephrotoxicity. symptoms nephrotic syndrome greatly improved indices fibrosis, phosphorylation Smad3, and expression alpha-smooth muscle actin (α-SMA), fibronectin,...
Gallbladder cancer (GBC) is the most common malignancy of biliary tract, with extremely dismal prognosis. Limited therapeutic options are available for GBC patients. We used whole-exome sequencing human to identify ErbB and epigenetic pathways as two vulnerabilities in GBC. screened focused small-molecule libraries that target these using cell lines identified mTOR inhibitor INK-128 histone deacetylase (HDAC) JNJ-26481585 compounds inhibited proliferation at low concentrations. Both...
Telomeres are specialized chromatin structures at the end of chromosomes. Telomere dysfunction can lead to chromosomal abnormalities, DNA damage responses, and even cancer. In mammalian cells, a six-protein complex (telosome/shelterin) is assembled on telomeres through interactions between various domain six telomere proteins (POT1, TPP1, TIN2, TRF1, TRF2 RAP1), functions in maintenance protection. Within telosome, TPP1 interacts directly with POT1 TIN2 help mediate telosome assembly....
Gallbladder cancer (GBC) is a rare malignancy of the biliary system and characterized by early metastasis poor prognosis. To date, no efficient treatment available for GBC patients. Based on data from cBioPortal, TIMER, GDSC, we performed an unbiased screening with 25 candidate compounds that predominantly target ErbB family identified HKI-272, highly selective EGFR/ErbB2 inhibitor, displayed decreased IC50 values in three cell lines. HKI-272 not only promoted gemcitabine-mediated...