A5103017898- Helicobacter pylori-related gastroenterology studies
- Reproductive biology and impacts on aquatic species
- Inflammasome and immune disorders
- Veterinary medicine and infectious diseases
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Antifungal resistance and susceptibility
- Aquaculture Nutrition and Growth
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Invertebrate Immune Response Mechanisms
- Mycobacterium research and diagnosis
- Probiotics and Fermented Foods
- Fluoride Effects and Removal
- Protein Kinase Regulation and GTPase Signaling
- Autoimmune and Inflammatory Disorders Research
- Heme Oxygenase-1 and Carbon Monoxide
- Fungal Infections and Studies
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Metabolomics and Mass Spectrometry Studies
- Growth Hormone and Insulin-like Growth Factors
- Gout, Hyperuricemia, Uric Acid
- Osteoarthritis Treatment and Mechanisms
- Cerebrovascular and genetic disorders
Zhejiang University
2023-2025
First Affiliated Hospital Zhejiang University
2024-2025
Peking University
2002-2024
Peking University People's Hospital
2015-2024
Stomatology Hospital
2023
Jinan University
2020-2022
Shanghai Jiao Tong University
2004-2021
State Key Laboratory of Oncogene and Related Genes
2019-2021
Shanghai Cancer Institute
2019-2021
Renji Hospital
2014-2021
Abstract Hepatocellular carcinoma (HCC) is a malignancy with poor prognosis. Surgery combined chemotherapy has been recommended as curative regimen for HCC. Nevertheless, the anticancer mechanisms of chemicals in hepatocellular remain unclear. Pyroptosis type programmed necrosis, and its mechanism poorly understood. The efficacy arsenic trioxide nanoparticles treatment HCC were explored this research. Arsenic alone conveniently administered to mice intratumorally using needle. Compared As 2...
Helicobacter pylori (H. pylori) infects more than half of the world's population, causing chronic gastritis, peptic ulcers and gastric cancer. Urease B subunit (UreB), a conserved protein H. pylori, is capable inducing specific CD4(+) T-cell responses provides protection against this infection. Previous studies have confirmed effectiveness rUreB vaccines in generating T-cell-mediated protection, but less known regarding roles different subtypes immunity, such as Th1, Th2 Th17, particularly...
DFNA5 (GSDME) belongs to Gasdermin familily that is involved in a variety of cancers and triggers cell pyroptosis after chemical treatment. However, the relationship between prognosis immune cells diverse has been receiving little attention. Tumor infiltration exhaustion may associate with patients prognosis. The roles tumor have not clarified.The expression level was determined by Tumour Immune Estimation Resource Oncomine database. Then impacts were assessed Kaplan-Meier plotter ULACAN....
Abstract Complete blood blockage and low ectopic embolism risk are urgently needed for transcatheter arterial chemoembolization (TACE) treatment. However, the clinically available embolic reagents still face huge challenges of fast recanalization undesirable migration. In present work, a temperature‐sensitive poloxamer 407 (F127)/hydroxymethyl cellulose (HPMC)/sodium alginate (SA)‐derived hydrogel (FHSgel) is explored as novel material in TACE With increasing temperature, this FHSgel...
Type 2 diabetes mellitus (T2DM) exacerbates irreversible bone loss in periodontitis, but the mechanism of impaired regeneration caused by abnormal metabolic process T2DM remains unclear. Exosomes are regarded as critical mediator diabetic impairment via organ or tissue communication. Here, we find that abnormally elevated exosomes derived from metabolically liver significantly enriched periodontal region and induced pyroptosis ligament cells (PDLCs). Mechanistically, fatty acid synthase...
Binding of La3+ to calmodulin (CaM) and its effects on the complexes CaM CaM-binding peptide, polistes mastoparan (Mas), were investigated by nuclear magnetic resonance (NMR) spectroscopy, fluorescence circular dichroism stopped-flow method. The four binding sites identified as same Ca2+ through NMR titration uniformly 15N-labeled CaM. showed a slightly higher affinity N-terminal domain than that C-terminal. Large differences between 1H-15N heteronuclear single quantum coherence (HSQC)...
Candida dubliniensis is closely related to albicans, a major causative agent of candidiasis, and primarily associated with oral colonization infection in human immunodeficiency virus (HIV)-positive patients. Despite the high similarity genomic phenotypic features between 2 species, C. much less virulent prevalent than albicans. The ability change morphological phenotypes striking feature species linked virulence. In this study, we report novel phenotype, gray dubliniensis. Together...
// Bin Li 1 , Hanmei Yuan Chen 2 Heqiang Sun Jian Hu 3, 4 Shanshan Wei Zhuo Zhao Quanming Zou and Chao Wu National Engineering Research Center of Immunological Products, Department Microbiology Biochemical Pharmacy, College Third Military Medical University, Chongqing, PR China Blood Transfusion, Xinqiao Hospital, 3 Intensive Care Unit, Chengdu General Chengdu, Gastroenterology, Correspondence to: Wu, email: wuchao99261@163.com Zou, qmzou2007@163.com Keywords: adjuvants, vaccine, protection,...
Disrupted immune response is an important feature of many neurodegenerative conditions, including sepsis-associated cognitive impairment. Accumulating evidence has demonstrated that memory occurs in microglia, which a significant impact on pathological hallmarks neurological diseases. However, it remains unclear whether can cause subsequent alterations the brain and affect neurobehavioral outcomes sepsis survivors. In present study, mice received daily intraperitoneal injection low-dose...
Staphylococcal enterotoxin B (SEB) is one of the most potent Staphylococcus aureus exotoxins (SEs). Due to its conserved sequence and stable structure, SEB might be a good candidate antigen for MRSA vaccines. Although cellular immune responses are well-characterized, much less known regarding SEB-specific humoral responses, particularly detailed epitope mapping. In this study, we utilized recombinant nontoxic mutant (rSEB) an AlPO4 adjuvant immunize BALB/c mice confirmed that rSEB can induce...
In mice, antigen-specific CD4+ T cell response is indispensible for the protective immunity against Helicobacter pylori (H. pylori). It has been demonstrated that neuraminyllactose-binding hemagglutinin (HpaA) immunization protected mice from H. infection in a dependent manner. However, much remains unclear concerning human responses to HpaA. We conducted systematic study here explore immunodominant, HpaA-specific infected individuals. found varied remarkably their magnitude and had broad...