A5023238050- Growth Hormone and Insulin-like Growth Factors
- Renal Diseases and Glomerulopathies
- Hypothalamic control of reproductive hormones
- Chronic Kidney Disease and Diabetes
- Sexual Differentiation and Disorders
- Renal and related cancers
- Metabolism and Genetic Disorders
- Ovarian function and disorders
- Diabetes and associated disorders
- Acute Kidney Injury Research
- Lipid metabolism and disorders
- Birth, Development, and Health
- Urinary Tract Infections Management
- Genetic and Kidney Cyst Diseases
- Childhood Cancer Survivors' Quality of Life
- Complement system in diseases
- Pancreatic function and diabetes
- RNA modifications and cancer
- Diet and metabolism studies
- Vasculitis and related conditions
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- RNA regulation and disease
- MicroRNA in disease regulation
- Genetic Syndromes and Imprinting
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
China Medical University
2015-2025
Ningxia Medical University
2016-2025
Second Affiliated Hospital of Nanjing Medical University
2025
Sichuan University
2024
Takeda (France)
2021
Takeda (Japan)
2021
Women's Hospital, School of Medicine, Zhejiang University
2019-2020
First Hospital of China Medical University
2019
Abstract Background Emerging evidence has shown that circular RNAs (circRNAs) play essential roles in cancer biology and are potential biomarkers targets for therapy. However, the expression function of circRNAs ovarian carcinogenesis its progression remain elusive. Methods RNA sequencing was performed to reveal circRNA profiles cancerous normal tissues. Single-molecule in-situ hybridization used quantify circPLEKHM3 tumor Cell-based in-vitro in-vivo assays were subsequently conducted...
Aicardi-Goutières syndrome (AGS) is a genetically heterogeneous type-I interferonopathy presenting in infancy with intracranial calcifications, white matter lesions, and brain atrophy. AGS7, caused by gain-of-function (GOF) mutations the IFIH1 gene, triggers excessive interferon production, leading to autoimmune responses. We describe an 18-year-old female diagnosed AGS7 due somatic GOF mutation IFIH1. In 2014, she presented multiple joint swelling, facial rash, hair loss, received diagnosis...
We assessed the efficacy and safety of a weekly pegylated human growth hormone (PEG-rhGH) (Jintrolong) vs daily rhGH for children with deficiency (GHD).Phase II III, multicenter, open-label, randomized controlled trials.108 343 treatment-naive GHD from 6 hospitals in China were enrolled phase III studies respectively. Patients study 1:1:1 to Jintrolong (0.1 mg/kg/week PEG-rhGH complex), (0.2 complex) or (0.25 mg/kg/week) 25 weeks. 2:1 ratio The primary endpoint both was height velocity (HV)...
Background and Aims A novel bioactive peptide, mitochondrial-derived peptide (MOTS-c), has recently attracted attention as a potential prevention or therapeutic option for obesity type 2 diabetes mellitus (T2DM). MOTS-c profiles have not yet been reported in human T2DM. We aimed to determine circulating levels explore the association between various metabolic parameters. Methods In this case-control study, 40 obese children adolescents (27 males) 57 controls (40 were recruited Hubei Province...
To explore the approaches and diagnostic yield of genetic testing for renal disease in children, we describe genotype phenotype national cohort children with from 13 different regions China recruited 2014 to 2018 by building up multicenter registration system (Chinese Children Genetic Kidney Disease Database, CCGKDD). diagnosis was confirmed 42.1% our 1001 pediatric patients clinical suspicion a disease. Of 106 distinct monogenetic disorders detected, 15 accounted 60.7% diagnoses. The 29.1%...
Abstract Rare diseases are usually chronically debilitating or even life-threatening with diagnostic and therapeutic challenges in current clinical practice. It has been estimated that 80% of rare genetic origin, thus genome sequencing-based diagnosis offers a promising alternative for rare-disease management. In this study, 79 individuals from 16 independent families were performed whole-genome sequencing (WGS) an effort to identify the causative mutations distinct largely clinically...
Objective: Recombinant human growth hormone (rhGH) replacement therapy in children generally requires daily subcutaneous (sc) injections, which may be inconvenient for patients. Jintrolong ® is a PEGylated rhGH with the purpose of weekly sc injections. The aim current study was to examine pharmacokinetics, pharmacodynamics, safety, and tolerability multiple doses vs rhGH. Design methods: Twelve deficiency participated this single-center, open-label, crossover Phase I trial. All subjects...
Abstract Context The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric deficiency (GHD) is limited. Objective This study aimed to examine the effectiveness and safety PEG-rhGH children with GHD real world, as well effects dose on patient outcomes. Design A prospective, observational, posttrial (NCT03290235). Setting, participants intervention Children were enrolled from 81 centers China 4 individual clinical trials received weekly 0.2 mg/kg/wk (high-dose)...
STUDY QUESTIONCan the chemokine CXCL6 affect trophoblast cell migration and invasion in human first-trimester placenta?
Abstract Chronic Kidney Disease (CKD) is a global health challenge, with acute kidney injury (AKI) from ischemia‐reperfusion (IRI) as common cause. This study explored the role of Hepatocyte Nuclear Factor 3 alpha (HNF3α/FOXA1) in renal fibrosis and CKD after IRI. biopsy specimens patients mouse models (IRI or unilateral ureteral obstruction) showed HNF3α upregulation fibrotic kidneys, linked to function decline. Additional experiments demonstrated that deletion mitigated IRI‐induced...
Reduction of pancreatic β-cells mass, major secondary to increased apoptosis, is increasingly recognized as one the main contributing factors pathogenesis type 2 diabetes (T2D), and saturated free fatty acid palmitate has been shown induce endoplasmic reticulum (ER) stress that may contribute promoting apoptosis. Recent literature suggests valproate, a diffusely prescribed drug in treatment epilepsy bipolar disorder, can inhibit glycogen synthase kinase-3β (GSK-3β) activity cytoprotective...
Background Nephronophthisis-related ciliopathies (NPHP-RC) account for the majority of cases monogenetically caused end-stage renal disease (ESRD) in children. Exploring correlation between phenotype and genotype NPHP-RC is helpful early diagnosis management. We investigated spectra a Chinese multicentre cohort. Methods Crosss-ectional longitudinal data 60 patients from 57 families with pathogenic gene mutations distributed 22 regions China were collected into unified, anonymous database....
Objective Cardiovascular injury is a common complication of heat stroke (HS). However, the mechanism underlying vascular smooth muscle cells (VSMCs) following HS remains unclear.
Background Chronic Obstructive Pulmonary Disease (COPD) is a major global health concern, with lifestyle factors playing crucial role in its prevention. This study aims to explore the relationship between Life’s Crucial 9 (lc9) scores and COPD odds, assess mediating potential of lean body mass (LBM) this association. Methods used cross-sectional association lc9 score using data from National Health Nutrition Examination Survey (NHANES) 2007 2020. Weighted multivariate regression analyses...
Abstract Dent disease is a rare X‐linked recessive inherited tubular disease. In this multicenter study, the clinical presentation and genetic background of Chinese children with are studied to improve cognition diagnostic ability pediatricians. prospective cohort, we described genotype phenotype national cohort composed 45 pediatric probands belonging families from 12 different regions China recruited 2014 2018 by building up registration system. The CLCN5 gene 32 affected revealed 28...
Renal interstitial fibrosis (RIF) is characterized by excessive extracellular matrix deposition and involves epithelial-mesenchymal transition (EMT). The lncRNA taurine-upregulated gene 1 (TUG1) participates in EMT several cancers; however, the effect underlying mechanism of TUG1 RIF-related remain unclear. Here, we explored mechanisms which modulates RIF. An vivo model renal was established unilateral ureteral obstruction Balb/c mice. Human proximal tubular epithelial (HK-2) cells treated...
The aim of this study was to investigate the expression neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) in serum, urine renal tissues children with acute (AKI) Henoch-Schönlein purpura nephritis (A-on-C). A prospective single-center evaluation NGAL KIM-1 levels performed a cohort children. Blood 5-ml samples were collected from each patient for analysis using an ELISA. In addition, examined immunohistochemistry patients A-on-C HSPN. serum cystatin C,...