A5114929491- Growth Hormone and Insulin-like Growth Factors
- Seed Germination and Physiology
- Plant Stress Responses and Tolerance
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Hypothalamic control of reproductive hormones
- Plant Molecular Biology Research
- Sexual Differentiation and Disorders
- Diabetes Management and Research
- Metabolism and Genetic Disorders
- Plant Micronutrient Interactions and Effects
- Ovarian function and disorders
- Liver Disease Diagnosis and Treatment
- Rice Cultivation and Yield Improvement
- Childhood Cancer Survivors' Quality of Life
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Preterm Birth and Chorioamnionitis
- Photosynthetic Processes and Mechanisms
- Cellular Mechanics and Interactions
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant nutrient uptake and metabolism
Chengdu Women's and Children's Central Hospital
2016-2025
Nanjing Agricultural University
2021-2025
University of Electronic Science and Technology of China
2020-2024
Anhui Agricultural University
2010-2024
Ministry of Agriculture and Rural Affairs
2019-2024
Institute of Crop Sciences
2024
Chinese Academy of Agricultural Sciences
2024
Heilongjiang Bayi Agricultural University
2019-2022
Children's Center
2021
Northwest A&F University
2016-2019
Abstract Excessive nitrogen promotes the formation of nonproductive tillers in rice, which decreases use efficiency (NUE). Developing high-NUE rice cultivars through balancing uptake and productive remains a long-standing challenge, yet how these two processes are coordinated elusive. Here we identify transcription factor OsGATA8 as key coordinator tiller rice. negatively regulates by repressing ammonium transporter gene OsAMT3.2 . Meanwhile, it OsTCP19 , negative modulator tillering. We -H...
Tissue optical clearing enables imaging deeper in large volumes with high-resolution. Clear T2 is a relatively rapid method no use of solvents or detergents, hence poses great advantage on preservation diverse fluorescent labels. However, this suffers from insufficient tissue transparency, especially for adult mouse brain blocks. In work, we develop and versatile based , termed RTF (Rapid Triethanolamine Formamide), aiming better capability. The results show that can not only efficiently...
To explore the distribution and differences in intestinal microbiota girls with obesity-related precocious puberty relationship between puberty. 16 S rRNA gene amplicons from fecal samples obesity-complicated healthy children were sequenced to define microbial taxa. The α- β-diversity indices of microbiome significantly differed among three groups. At phylum level, proportions Firmicutes, Actinobacteriota, Bacteroidota, Bacteria, Campylobacterota, Acidobacteriota different. genus there...
Seed dormancy and germination are important agronomic traits in wheat (Triticum aestivum L.) because they determine pre-harvest sprouting (PHS) resistance thus affect grain production. These processes regulated by Gibberellic Acid-Stimulated Regulator (GASR) genes. In this study, we identified 37 GASR genes common wheat, which were designated TaGASR1-37. Moreover, 40 pairs of paralogous genes, only one had a Ka/Ks value greater than 1, indicating that most TaGASR have undergone negative...
Wiedemann–Steiner syndrome (WDSTS) is a rare genetic disorder characterized by facial gestalt, neurodevelopmental delay, skeletal anomalies and growth retardation, which caused variation of KMT2A gene. To date, only 2 Chinese WDSTS patients have been reported. Here, we report the phenotypes gene variations in 14 unrelated investigate phenotypic differences between French cohorts. Next generation sequencing was performed for each patient, variants were validated Sanger sequencing. The 16...
Trihelix transcription factors (TTFs) are photoresponsive proteins that have a representative three-helix structure (helix-loop-helix-loop-helix). Members of this gene family been reported to play roles in many plant processes. In study, we performed functional and evolutionary analysis the TTFs Moso bamboo (Phyllostachys edulis). A total 35 genes were identified grouped into five subfamilies (GT-1, GT-γ, GT-2, SIP1 SH4) according their structural properties. Gene showed most PeTTF had fewer...
SUMMARY Saline‐alkali stress has detrimental effects on growth and development of rice ( Oryza sativa L.). Domesticated cultivars with high saline‐alkali tolerance (SAT) are essential for sustainable agriculture. To explore the genomic basis underlying SAT in rice, we integrate genome‐wide association study (GWAS) selective sweep analysis using a core population consisting 234 grown saline normal fields across three consecutive years identify 70 genes associated signals selection evolution...
Response regulators are part of a two-component regulatory system.The type-A Arabidopsis response act as negative regulators.To understand the function in model monocot plant, rice (Japonica cultivar-group: Zhonghua11), we overexpressed two OsRR genes, OsRR3 and OsRR5 (pACT1:OsRR3 pACT1:OsRR5).We hoped to gain insight into their molecular cytokinin-signaling pathways.Both overexpressors had longer roots more lateral compared with Zhonghua11, when treated exogenous cytokinin.Using callus...
B-box (BBX) proteins are a type of zinc finger containing one or two domains. They play important roles in development and diverse stress responses plants, yet their wheat remain unclear.
Introduction: REAL6 is a randomized, multi-centre, open-labelled, active-controlled parallel group phase 3 trial (NCT04970654) investigating once-weekly somapacitan, reversible albumin-binding growth hormone (GH) derivative, in Chinese children with GH deficiency (GHD). Methods: 110 treatment-naïve patients were randomized 2:1 to somapacitan (0.16 mg/kg/week) or daily (Norditropin®; 0.034 mg/kg/day) for 52 weeks. Annualized height velocity (HV; cm/year) at week was the primary measurement....
Wheat is one of the most widely cultivated food crops worldwide, and safe production wheat essential to ensure security. Soil salinization drought have severely affected yield quality wheat. Valine-glutamine genes play important roles in abiotic stress response. This study assessed effect gene TaVQ14 on salt stresses resistance. Sequence analysis showed that encoded a basic unstable hydrophobic protein with 262 amino acids. Subcellular localization was localized nucleus. upregulated seeds...
Summary Soil salinity has negative impacts on food security and sustainable agriculture. Ion homeostasis, osmotic adjustment reactive oxygen species scavenging are the main approaches utilized by rice to resist salt stress. Breeding cultivars with high tolerance (ST) yield is a significant challenge due lack of elite alleles conferring ST. Here, we report that allele LEA12 OR , which encodes late embryogenesis abundant (LEA) protein from wild Oryza rufipogon Griff., improves increases under...
To investigate the features and treatment status of children with type 1 diabetes mellitus (T1DM) in China.
Objective: This study aimed to evaluate the clinical efficacy of recombinant human growth hormone (rhGH) in treatment children with idiopathic short stature (ISS) and deficiency (GHD) explore related factors affecting efficacy. Methods: The current research reflects a real-world study. A total 79 patients ISS 95 GHD (both groups pre-puberty) who had been treated rhGH for more than one year from January 2010 September 2019 were included this divided into two groups, ie, an group,...
Abstract Background Heterozygous mutations in the AT‐hook DNA‐binding motif containing one ( AHDC1 , OMIM * 615790) gene cause an autosomal dominant multisystem developmental disorder known as Xia‐Gibbs syndrome (OMIM #615829). typically presented with global delay, hypotonia, obstructive sleep apnea, seizures, delayed myelination, micrognathia, and other mild dysmorphic features. Methods Description of clinical materials two Chinese boys who were diagnosed based on presentations next...
Seed dormancy and germination determine wheat resistance to pre-harvest sprouting thereby affect grain yield quality. Arabidopsis VQ genes have been shown influence seed germination; however, the functions of not characterized.We identified 65 TaVQ in common named them TaVQ1-65. We 48 paralogous pairs, 37 which had Ka/Ks values greater than 1, suggesting that most experienced positive selection. Chromosome locations, gene structures, promoter element analysis, ontology annotations TaVQs...
Improvement of grain weight and size is an important objective for high-yield wheat breeding. In this study, 174 recombinant inbred lines (RILs) derived from the cross between Jing 411 Hongmangchun 21 were used to construct a high-density genetic map by specific locus amplified fragment sequencing (SLAF-seq). Three mapping methods, including inclusive composite interval (ICIM), genome-wide (GCIM), mixed linear model performed with forward-backward stepwise (NWIM), identify QTLs thousand...