A5091484412- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- T-cell and B-cell Immunology
- Genetic and phenotypic traits in livestock
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Transplantation: Methods and Outcomes
- Salivary Gland Disorders and Functions
- Rice Cultivation and Yield Improvement
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- Atherosclerosis and Cardiovascular Diseases
- Plant Molecular Biology Research
- Immunotherapy and Immune Responses
- Nuclear Structure and Function
- Inflammasome and immune disorders
- Celiac Disease Research and Management
- Hidradenitis Suppurativa and Treatments
- IL-33, ST2, and ILC Pathways
- Renal Transplantation Outcomes and Treatments
- Plant Disease Resistance and Genetics
- Wheat and Barley Genetics and Pathology
- Chromosomal and Genetic Variations
The University of Texas Southwestern Medical Center
2017-2025
Southwestern Medical Center
2019-2024
Southwestern University
2024
University of Missouri
2016-2020
Bioarray Genetics (United States)
2020
Iowa State University
2013-2019
Kansas State University
2008-2014
University of Iowa
2014
Nanjing Agricultural University
2005-2008
Henan Academy of Agricultural Sciences
2007
There is tremendous interest in using association mapping to identify genes responsible for quantitative variation of complex traits with agricultural and evolutionary importance. Recent advances genomic technology, impetus exploit natural diversity, development robust statistical analysis methods make appealing affordable plant research programs. Association identifies trait loci (QTLs) by examining the marker‐trait associations that can be attributed strength linkage disequilibrium between...
HomeCirculationVol. 144, No. 6In-Depth Evaluation of a Case Presumed Myocarditis After the Second Dose COVID-19 mRNA Vaccine Free AccessCase ReportPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissionsDownload Articles + Supplements ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toSupplemental MaterialFree ReportPDF/EPUBIn-Depth Alagarraju Muthukumar, Madhusudhanan Narasimhan, Quan-Zhen Li, Lenin Mahimainathan, Imran Hitto, Franklin...
Salinity stress progressively reduces plant growth and productivity, while has developed complex signaling pathways to confront salt stress. However, only a few genetic variants have been identified mediate tolerance in the major crop rice, molecular mechanism remains poorly understood. Here, we identify ten candidate genes associated with salt-tolerance (ST) traits by performing genome-wide association analysis rice landraces. We characterize two ST-related genes, encoding transcriptional...
Sorghum, an ancient old-world cereal grass, is the dietary staple of over 500 million people in more than 30 countries tropics and semitropics. Its C4 photosynthesis, drought resistance, wide adaptation, high nutritional value hold promise to alleviate hunger Africa. Not present other major cereals, such as rice, wheat, maize, condensed tannins (proanthocyanidins) pigmented testa some sorghum cultivars have been implicated reducing protein digestibility but recently shown promote human...
The complex genomes of many economically important crops present tremendous challenges to understand the genetic control quantitative traits with great importance in crop production, adaptation, and evolution. Advances genomic technology need be integrated strategic design novel perspectives break new ground. Complementary individual-gene–targeted research, which remains challenging, a global assessment distribution trait-associated SNPs (TASs) discovered from genome scans can provide...
Sheath blight (ShB) caused by the soil-borne pathogen Rhizoctonia solani is one of most devastating diseases in rice world-wide. Global attention has focused on examining individual mapping populations for quantitative trait loci (QTLs) ShB resistance, but to date no study taken advantage association examine hundreds lines potentially novel QTLs. Our objective was identify QTLs via using 217 sub-core entries from USDA core collection, which were phenotyped with a micro-chamber screening...
The cultivated [Glycine max (L) Merr.] and wild soja Siebold & Zucc.] soybean species comprise wide variation in seed composition traits. Compared to soybean, contains low protein, high oil, sucrose. In this study, an interspecific population was derived from a cross between G. (Williams 82) (PI 483460B). This recombinant inbred line (RIL) of 188 lines sequenced at 0.3× depth. Based on 91 342 single nucleotide polymorphisms (SNPs), recombination events RILs were defined, high-resolution bin...
Introduction Immune checkpoint inhibitors (ICI) are a novel cancer therapeutic that have been successful in treating advanced malignancies; however, they also cause immune-related adverse events (irAE). Given some irAE clinically similar to traditional autoimmune diseases, autoantibodies suggested as possible biomarkers of irAE. However, there very little data on autoantibody investigation prior ICI. Our aim was determine if specific baseline were associated with and see changes...
Autoantibodies to nuclear antigens are hallmarks of systemic lupus erythematosus (SLE) where they contribute pathogenesis. However, there remains a gap in our knowledge regarding how different isotypes autoantibodies this autoimmune disease, including the production critical type I interferon (IFN) cytokines by plasmacytoid dendritic cells (pDCs) response immune complexes (ICs). We focused on IgA, which is second-most prevalent isotype serum and, along with IgG, deposited glomeruli...
Recent research has developed various promising methods to control for population structure in genomewide association mapping of complex traits, but systematic examination how well these perform under different genetic scenarios is still lacking. Appropriate controlling relationships among individuals need balance the concern false positives and statistical power, which can vary sample types. We used a series simulated samples empirical data sets from cross- self-pollinated species...
Markers with segregation ratio distortion are commonly observed in data sets used for quantitative trait locus (QTL) mapping. In this study, a multipoint method of maximum likelihood (ML) was newly developed to estimate the positions and effects loci (SDLs) two F 2 populations rice ( Oryza sativa L.), i.e. Taichung65/Bhadua (TB; japonica – indica cross) CPSLO17/W207-2 (CW; ). Of four parents, W207-2 Bhadua were found be spikelet semi-sterile stably inherited through selfing, fertility...
Abstract The clinical relevance of human leucocyte antigen‐G (HLA‐G) has been postulated in malignancies. Hepatocellular carcinoma (HCC) is a major contributor to cancer incidence and mortality worldwide; however, potential roles HLA‐G HCC remain unknown. In the current study, expression 219 primary lesions their adjacent non‐tumourous samples was analysed with immunohistochemistry. Correlations among various parameters were evaluated. Meanwhile, functional analysis transfected cell surface...
Complex trait dissection through association mapping provides a powerful complement to traditional linkage analysis. The genetic structure of an panel can be estimated by genomewide background markers and subsequently accounted for in Deciding the number is common issue that needs addressed many studies. We first showed adequacy relationship estimation influences maximum likelihood model explaining phenotypic variation demonstrated this influence with series computer simulations different...
Acquired lipodystrophy is often characterized as an idiopathic subtype of lipodystrophy. Despite suspicion immune-mediated pathology, biomarkers such autoantibodies are generally lacking. Here, we used unbiased proteome-wide screening approach to identify the adipocyte-specific lipid droplet protein perilipin 1 (PLIN1) in a murine model autoimmune polyendocrine syndrome type (APS1). We then tested for PLIN1 human subjects with acquired two independent severe breaks immune tolerance...