A5037939005- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Mechanical Circulatory Support Devices
- Parathyroid Disorders and Treatments
- Potassium and Related Disorders
- Electrolyte and hormonal disorders
- Cardiovascular and exercise physiology
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Renal function and acid-base balance
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Transplantation: Methods and Outcomes
- Sarcoidosis and Beryllium Toxicity Research
- Heart Rate Variability and Autonomic Control
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
- Galectins and Cancer Biology
- Eosinophilic Disorders and Syndromes
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
The University of Texas Southwestern Medical Center
2016-2025
Parkland Health & Hospital System
2020-2025
Southwestern Medical Center
2017-2024
Texas Health Harris Methodist Hospital Fort Worth
2024
Cleveland Clinic
2013-2021
Pfizer (United States)
2021
Oslo University Hospital
2018
University of Oslo
2018
University of North Texas at Dallas
2017
Korea University
2017
Background: Obesity may contribute to adverse outcomes in coronavirus disease 2019 (COVID-19). However, studies of large, broadly generalizable patient populations are lacking, and the effect body mass index (BMI) on COVID-19 outcomes— particularly younger adults—remains uncertain. Methods: We analyzed data from patients hospitalized with at 88 US hospitals enrolled American Heart Association’s Cardiovascular Disease Registry collection through July 22, 2020. BMI was stratified by World...
To develop and validate a novel, machine learning-derived model to predict the risk of heart failure (HF) among patients with type 2 diabetes mellitus (T2DM).Using data from 8,756 free at baseline HF, <10% missing data, enrolled in Action Control Cardiovascular Risk Diabetes (ACCORD) trial, we used random survival forest (RSF) methods, nonparametric decision tree learning approach, identify predictors incident HF. The RSF was externally validated cohort individuals T2DM using...
Acute myocarditis (AM) is thought to be a rare cardiovascular complication of COVID-19, although minimal data are available beyond case reports. We aim report the prevalence, baseline characteristics, in-hospital management, and outcomes for patients with COVID-19-associated AM on basis retrospective cohort from 23 hospitals in United States Europe.A total 112 suspected 56 963 hospitalized COVID-19 were evaluated between February 1, 2020, April 30, 2021. Inclusion criteria hospitalization...
HomeCirculationVol. 144, No. 6In-Depth Evaluation of a Case Presumed Myocarditis After the Second Dose COVID-19 mRNA Vaccine Free AccessCase ReportPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissionsDownload Articles + Supplements ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toSupplemental MaterialFree ReportPDF/EPUBIn-Depth Alagarraju Muthukumar, Madhusudhanan Narasimhan, Quan-Zhen Li, Lenin Mahimainathan, Imran Hitto, Franklin...
Background— Recent epidemiological studies have implicated chloride, rather than sodium, as the driver of poor survival previously attributed to hyponatremia in heart failure. Accumulating basic science evidence has identified chloride a critical factor renal salt sensing. Our goal was probe physiology bridging this and literature. Methods Results— Two failure cohorts were included: (1) observational: patients receiving loop diuretics at Yale Transitional Care Center (N=162) (2)...
<h3>Objective</h3> Cardiac amyloidosis (CA) is a rapidly progressive disease that portends poor prognosis. Our objective was to evaluate the prognostic impact of relative regional strain ratio (RRSR, measure apical sparing longitudinal (LS)) in CA. <h3>Methods</h3> This retrospective study evaluating 97 patients with CA from 2004 2013. Patients were included if they met criteria for based on endomyocardial biopsy or advanced imaging coupled either extracardiac genetic analysis. Baseline...
The aim of this analysis was to determine the long-term prognostic value lower serum chloride in patients with stable chronic heart failure. Electrolyte abnormalities are prevalent Little is known regarding implications chloride.Serum measured 1673 consecutively consented a history failure undergoing elective diagnostic coronary angiography. All were followed for 5-year all-cause mortality, and survival models adjusted variables that confounded chloride-risk relationship. average level 102 ±...
Background: In the phase 3 randomized controlled study, ATTRibute-CM, acoramidis, a transthyretin (TTR) stabilizer, demonstrated significant efficacy on primary endpoint. Participants with amyloid cardiomyopathy (ATTR-CM) who completed ATTRibute-CM were invited to enroll in an open-label extension study (OLE). We report and safety data of acoramidis participants enrolled ongoing OLE. Methods: previously received through Month 30 (M30) continued receive it (continuous acoramidis), those...
Duchenne muscular dystrophy (DMD) is frequently complicated by development of a cardiomyopathy. Despite significant medical advances provided to DMD patients over the past 2 decades, there remains group who die prematurely. The current study sought identify set prognostic factors that portend worse outcome among adult patients.A retrospective cohort 43 consecutive was followed in UT Southwestern Neuromuscular Cardiomyopathy Clinic. Clinical data were abstracted from electronic record...
<h3>Importance</h3> Heart failure (HF) incidence is declining among Medicare beneficiaries. However, the epidemiological mechanisms underlying this decline are not well understood. <h3>Objective</h3> To evaluate trends in HF across risk factor strata. <h3>Design, Setting, and Participants</h3> Retrospective, national cohort study of 5% all fee-for-service beneficiaries with no prior followed up from 2011 to 2016. The examined annual groups without primary factors (hypertension, diabetes,...
To evaluate the associations between long-term change and variability in glycemia with risk of heart failure (HF) among patients type 2 diabetes mellitus (T2DM).Among participants T2DM enrolled Action to Control Cardiovascular Risk Diabetes (ACCORD) trial, HbA1c was assessed from stabilization following enrollment (8 months) 3 years follow-up as follows: average successive (ASV) (average absolute difference values), coefficient variation (SD/mean), SD. Participants HF at baseline or within...