A5084467800- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heart Failure Treatment and Management
- Sarcoidosis and Beryllium Toxicity Research
- Cardiovascular Function and Risk Factors
- Parathyroid Disorders and Treatments
- Cardiac pacing and defibrillation studies
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Potassium and Related Disorders
- Cardiac Imaging and Diagnostics
- Electrolyte and hormonal disorders
- IL-33, ST2, and ILC Pathways
- Viral Infections and Immunology Research
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroendocrine Tumor Research Advances
- Cardiac electrophysiology and arrhythmias
- Pulmonary Hypertension Research and Treatments
Mayo Clinic
2016-2025
Mayo Clinic in Arizona
2015-2024
WinnMed
2014-2024
Mayo Clinic in Florida
2009-2024
Soochow University
2023
Intermountain Healthcare
2023
University of Michigan
2023
Hennepin County Medical Center
2015
Brigham and Women's Hospital
2013-2015
Clinical Research Institute
2013-2015
Background— The prevalence and clinical significance of right ventricular (RV) systolic dysfunction (RVD) in patients with heart failure preserved ejection fraction (HFpEF) are not well characterized. Methods Results— Consecutive, prospectively identified HFpEF (Framingham HF criteria, ≥50%) (n=562) from Olmsted County, Minnesota, underwent echocardiography at diagnosis follow-up for cause-specific mortality hospitalization. RV function was categorized by tertiles tricuspid annular plane...
Congestion is the most frequent cause for hospitalization in acute decompensated heart failure. Although decongestion a major goal of therapy, it unclear how clinical components congestion (eg, peripheral edema, orthopnea) contribute to outcomes after discharge or well maintained.A post hoc analysis was performed 496 patients enrolled Diuretic Optimization Strategy Evaluation Acute Decompensated Heart Failure (DOSE-AHF) and Cardiorenal Rescue Study (CARRESS-HF) trials during with failure...
<h3>Importance</h3> Heart failure (HF) with preserved ejection fraction (HFpEF) is common, frequently associated ventricular wall thickening, and has no effective therapy. Transthyretin amyloid cardiomyopathy (ATTR-CM) can cause the HFpEF clinical phenotype, highly therapy, believed to be underrecognized. <h3>Objective</h3> To examine prevalence of ATTR-CM without systematic screening in patients thickening. <h3>Design, Setting, Participants</h3> This population-based cohort study assessed...
Background Microvascular inflammation may contribute to the pathogenesis of both heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension (PH). We investigated whether biomarker C-reactive protein (CRP) was associated clinical characteristics, disease severity or PH in HFpEF. Methods Patients Phosphodiesterase-5 Inhibition Improve Clinical Status Exercise Capacity Diastolic Heart (RELAX) trial had baseline high-sensitivity CRP levels measured (n = 214). exercise...
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a form of heart failure (HF) with preserved ejection fraction (HFpEF). Technetium Tc 99m pyrophosphate scintigraphy (PYP) enables ATTR-CM diagnosis. It unclear which patients HFpEF have sufficient risk to warrant PYP.To derive and validate simple score predict increased in HFpEF.Retrospective cohort study 666 HF (ejection ≥ 40%) suspected referred for PYP at Mayo Clinic, Rochester, Minnesota, from May 10, 2013, through August 31, 2020. These...
Background Soluble ST2 is a biomarker that elevated in certain systemic inflammatory diseases. Comorbidity‐driven microvascular inflammation postulated to play key role heart failure with preserved ejection fraction ( HF p EF ) pathophysiology, but data on how sST 2 relates clinical characteristics or conditions biomarkers are limited. We sought determine circulating levels and correlates of pEF. Methods Results At enrollment, patients (n=174) from the Phosphodiesterase‐5 Inhibition Improve...
Summary Improvement in survival Light chain (AL) amyloidosis has been seen over recent decades, enabling more patients to achieve long‐term survival. Patients with AL who survived ≥10 years from time of diagnosis ( n = 186) were the subject this study. Ten‐year survivors represented 22% total population. These characterized by favourable patient, organ and plasma cell features. Of note, trisomies less common among 10‐year compared those did not survive 10 years. All‐time best haematological...
Transthyretin amyloid cardiomyopathy (ATTR-CM) is increasingly recognized as a treatable cause of heart failure (HF). Advances in diagnosis and therapy have increased the number patients diagnosed at early stages, but prognostic data on without HF symptoms are lacking. Moreover, it unknown whether asymptomatic benefit from initiation transthyretin (TTR) stabilizers.The aim this study was to describe natural history prognosis ATTR-CM symptoms.Clinical characteristics outcomes with were...
Radiofrequency (RF) ablation for ventricular tachycardia (VT) has high failure rates. Whether endocavitary structures (ECS) such as the papillary muscles (PMs), moderator bands (MBs), or false tendons (FTs) impact VT is unknown.We retrospectively reviewed records of 190 consecutive patients presenting and identified 46 (24%) where ECS affected ablation. In 31 (67%), created difficulty with catheter manipulation (n = 20), interpretation pace map data 7), accurately defining a scar 4). 15...
High-sensitivity cardiac troponin assays have potent prognostic value in stable cardiovascular disease cohorts. Our objective was to assess the utility of a novel I (cTnI) high-sensitivity assay, independently and combination with amino-terminal pro-B-type natriuretic peptide (NT-proBNP), for future development heart failure mortality general community.A well-characterized community-based cohort 2042 participants underwent clinical assessment echocardiographic evaluation. Baseline...
The role of coronary microvascular disease and its impact on functional energetic reserve in heart failure with preserved ejection fraction (HFpEF) remains unclear. We hypothesized that response to submaximal pharmacologic stress (dobutamine), patients HFpEF have impairment left ventricular (LV) myocardial mechanical (external work [EW]), (myocardial O2 consumption [MVO2]), blood flow (MBF) reserve. further assessed whether coupling MBF EW is impaired associated compensatory increases or...