A5065491673- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Cardiac Health and Mental Health
- Nutrition and Health in Aging
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diet and metabolism studies
- Hemodynamic Monitoring and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Heart Rate Variability and Autonomic Control
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Nitric Oxide and Endothelin Effects
- Cerebrovascular and Carotid Artery Diseases
- Muscle Physiology and Disorders
- Complement system in diseases
- Renal and related cancers
- Gut microbiota and health
- Medical and Biological Ozone Research
- Muscle activation and electromyography studies
- Genetic Syndromes and Imprinting
Cleveland Clinic Lerner College of Medicine
2023-2025
Cleveland Clinic
2014-2024
Tel Aviv University
2006
Dysregulation of immune responses has been linked to the generation immunoglobulin G (IgG) autoantibodies that target human β1ARs and contribute deleterious cardiac outcomes. Given benefits β-blockers observed in patients harboring IgG3 subclass autoantibodies, we investigated role these β1AR function. Serum purified IgG3(+) from with onset cardiomyopathy were tested using embryonic kidney (HEK) 293 cells expressing β1ARs. Unexpectedly, pretreatment serum or impaired dobutamine-mediated...
Motivation: Skeletal muscle degeneration (sarcopenia) is more prevalent in patients with heart failure (HF) than the general population and associated worsened outcomes. However, HF-associated remains incompletely understood. Goal(s): To evaluate quantitative MRI calf compartments of HF to investigate associations function overall condition. Approach: Relaxometric (T1/T2/T1ρ) proton density fat fraction (PDFF) measures were obtained HF. Functional survey obtained. Correlation...
Introduction: Although cardiopulmonary exercise testing (CPET) is the standard test for functional capacity and risk stratification in patients with HFrEF, integrative use of different CPET parameters prognostication warranted. Hypothesis: A differential HFrEF phenogroups can be achieved by means an unsupervised machine learning algorithm parameters. Methods: We reviewed medical records 1,067 (EF ≤ 40%) undergoing from 12/2012 to 9/2020. Patients hypotensive or bradycardic response during...
Summary form only given. The aim of this project was to build a portable system designed monitor on daily basis the severity pulmonary edema in chronic heart failure (CHF) patients. As for today, current methods monitoring these patients are inaccurate (weighing), or involve ionizing radiation (CT imaging). proposed is based principles bio-impedance - non invasive technique which retrieves information regarding electrical characteristics internal tissues by applying small amplitude currents...
ABSTRACT Autoantibodies recognizing human β1ARs generated due to dysregulation in autoimmune response are generally associated with deleterious cardiac outcomes. However, cellular studies show that isolates of β1AR autoantibody from patients differentially modulate function. autoantibodies belong the IgG class immunoglobulins, however it is not known whether sub-classes mediate variability responses. To determine IgG3 subclass uniquely function, HEK293 cells stably expressing were utilized....
Introduction: Microalbuminuria can be a presentation of microvascular complication in diabetes mellitus (DM). Hypothesis: is associated with impaired exercise performance chronic HF DM patients. Methods: We retrospectively analyzed cardiopulmonary testing (CPET) database 255 patients that had urine microalbumin test between December 2012 and September 2019. Demographic data CPET parameters were compared the who not microalbuminuria which was defined by microalbumin/creatinine ratio ≥ 30...
Introduction: While implicated in both cardiac and renal dysfunction, it remains unclear if myeloperoxidase (MPO) plays a role the development of acute cardiorenal syndrome (CRS). We developed an assay to quantify MPO inhibitory capacity (MIC) assess plasma sample’s inhibit activity. Hypothesis: hypothesized that unopposed activity (less inhibition) contributes CRS greater inhibition leads improved clinical outcomes. Methods: 90 paired samples heart failure (AHF) patients were collected at...