A5016366707- Adrenal Hormones and Disorders
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Adipose Tissue and Metabolism
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Nuclear Structure and Function
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Myasthenia Gravis and Thymoma
- Celiac Disease Research and Management
- SARS-CoV-2 and COVID-19 Research
- Urticaria and Related Conditions
- Respiratory viral infections research
- Cancer Genomics and Diagnostics
- Birth, Development, and Health
- Biotin and Related Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Autoimmune Neurological Disorders and Treatments
- Pancreatic function and diabetes
- Bone Metabolism and Diseases
- Sperm and Testicular Function
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- SARS-CoV-2 detection and testing
- Influenza Virus Research Studies
Merck & Co., Inc., Rahway, NJ, USA (United States)
2024-2025
University of California, San Francisco
2009-2022
Diabetes Australia
2014-2019
National Institutes of Health
2014
National Institute of Diabetes and Digestive and Kidney Diseases
2014
Virginia Commonwealth University
2014
Vanderbilt University
2014
ARUP Laboratories (United States)
2014
ARUP Institute for Clinical and Experimental Pathology
2014
The University of Texas Southwestern Medical Center
1998
Autoantibodies against cytokines, chemokines, and growth factors inhibit normal immunity are implicated in inflammatory autoimmune disease diseases of immune deficiency. In an effort to evaluate serum from immunodeficient patients for Abs a high-throughput unbiased manner, we constructed multiplex protein microarray detection factor-binding used the detect autoantibody targets SLE. We designed nitrocellulose-surface containing human other circulating proteins demonstrated that array...
Autoimmunity targeting the lung-specific antigen BPIFB1 may be important to pathogenesis of interstitial lung disease.
The identification of autoantigens remains a critical challenge for understanding and treating autoimmune diseases. Autoimmune polyendocrine syndrome type 1 (APS1), rare monogenic form autoimmunity, presents as widespread autoimmunity with T B cell responses to multiple organs. Importantly, autoantibody discovery in APS1 can illuminate fundamental disease pathogenesis, many the antigens found extend more common Here, we performed proteome-wide programmable phage-display (PhIP-Seq) on sera...
Acquired lipodystrophy is often characterized as an idiopathic subtype of lipodystrophy. Despite suspicion immune-mediated pathology, biomarkers such autoantibodies are generally lacking. Here, we used unbiased proteome-wide screening approach to identify the adipocyte-specific lipid droplet protein perilipin 1 (PLIN1) in a murine model autoimmune polyendocrine syndrome type (APS1). We then tested for PLIN1 human subjects with acquired two independent severe breaks immune tolerance...
Molnupiravir, a prodrug of β-D-N4-hydroxycytidine (NHC), is administered orally as four 200 mg capsules twice daily for 5 days to treat COVID-19. This randomized, open-label, four-treatment sequence, three-period crossover study (NCT06615869) evaluated the bioequivalence new single 400 oral dose molnupiravir tablet Formulation 1 (F1) currently authorized capsule formulation (administered two capsules) by comparing plasma pharmacokinetics NHC following administration healthy participants. The...
Human respiratory syncytial virus (RSV) infections can result in hospitalization and/or death among vulnerable populations. Molnupiravir is a prodrug of ß-D-N4-hydroxycytidine, which has broad-spectrum preclinical activity against RNA viruses. We conducted pilot trial evaluating molnupiravir for RSV infection. Double-blind, placebo-controlled, phase 2a human challenge study healthy adults (≥ 18 to ≤ 55 years old). Eligible participants were randomized 1:1:1 prophylaxis (5 days, 800 mg twice...
While improvements in genetic analysis have greatly enhanced our understanding of the mechanisms behind pancreatitis, it continues to afflict many families for whom hereditary factors remain unknown. Recent evaluation a patient with strong family history pancreatitis sparked us reexamine large kindred originally reported over 50 years ago an autosomal dominant inheritance pattern chronic diabetes and pancreatic adenocarcinoma. Whole exome sequencing identified rare missense mutation gene...
Primary ovarian insufficiency (POI) resulting from autoimmunity is a poorly understood clinical condition lacking in effective treatments. Understanding the targets of autoimmune response and induction ovarian-specific tolerance would allow development focused therapies to preserve fertility an at-risk population. MATER (maternal antigen that embryos require) known autoantigen targeted syndromes POI. We attempt induce via transgenic expression on potentially tolerogenic antigen-presenting...
Osteocalcin produced by bone regulates testosterone production and male fertility.
Abstract Ovarian autoimmunity is a poorly understood cause of premature ovarian failure and infertility among women. Diagnosis autoimmune disease (AOD) challenging due to the lack specific sensitive autoantibody tests, pathogenesis antigens targeted in AOD remain largely unknown. We have established novel mouse model using Aire-deficient mouse. Like APS1 patients that AIRE, mice develop multiple organs, including ovary, breakdown central tolerance. female oophoritis manifested by 100%...
Individuals with chronic liver or kidney disease are at increased risk of severe COVID-19. Molnupiravir is an orally administered antiviral authorized for the treatment mild-to-moderate COVID-19 in adults progression to disease. Two nonrandomized, open-label, single-dose, multicenter, phase 1 trials were conducted investigate effects hepatic and renal impairment on tolerability pharmacokinetics molnupiravir (800 mg) its metabolite β-D-N4-hydroxycytidine (NHC; NCT05386589/NCT05386758). The...
ABSTRACT Background Acquired lipodystrophy is often characterized as an idiopathic subtype of lipodystrophy. Despite suspicion immune-mediated pathology, biomarkers such autoantibodies are generally lacking. Methods Here, we used unbiased proteome-wide screening approach to identify the adipocyte specific lipid droplet protein Perilipin-1 in a murine model Autoimmune Polyendocrine Syndrome 1 (APS1). We then tested for PLIN1 human subjects with two independent severe breaks immune tolerance...
Abnormal regulation of glucagon secretion contributes to impaired glycemic control in patients with T1D. We conducted two 12-week, double-blind, randomized, placebo-controlled trials evaluate the efficacy blocking action receptor antagonist antibody, volagidemab (VOLA), on In both trials, participants were randomized a 1:1:1 fashion weekly subcutaneous injection placebo (PBO), VOLA 35 mg, or 70 mg. Participants Trial 1 (n=75) unblinded and 2 (n=78) blinded data from study-provided continuous...