A5059405802- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Digestive system and related health
- Hepatitis Viruses Studies and Epidemiology
- Gallbladder and Bile Duct Disorders
- Hepatitis B Virus Studies
- Congenital Anomalies and Fetal Surgery
- Intestinal Malrotation and Obstruction Disorders
- Diet and metabolism studies
- Hepatitis C virus research
- Liver physiology and pathology
- Viral gastroenteritis research and epidemiology
- Clinical Nutrition and Gastroenterology
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Folate and B Vitamins Research
- Cystic Fibrosis Research Advances
- Gastroesophageal reflux and treatments
- Nutrition and Health in Aging
- Tracheal and airway disorders
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
Universidade Federal de Ciências da Saúde de Porto Alegre
2019-2024
Hospital de Clínicas de Porto Alegre
2004-2021
Hospital de Santo António
2019
Hospital Nossa Senhora da Conceição
2019
Universidade Federal do Rio Grande do Sul
2007-2017
Pontifícia Universidade Católica de Goiás
2017
Office of Adolescent Health
2016
Universidade de Santa Cruz do Sul
2015
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
2012
Hospital de Niños Superiora Sor María Ludovica
2011
Because of the poor results in stage III B carcinoma cervix with standard treatment using radiotherapy alone, we designed a randomized trial to determine whether administration chemotherapy before pelvic irradiation would improve survival. Between May 1984 and August 1986, 107 patients previously untreated squamous cell were randomly assigned, after stratification by age (less than 50 v greater years), extent parametrial involvement (unilateral bilateral), lymphangiographic findings...
Objective To investigate the significance of endoscopic nodular gastritis associated with Helicobacter pylori infection. Methods This prospective study included 185 children (50.8% boys) aged 1 to 12 years (mean, 6.9 ± 3.0 years) who underwent upper intestinal endoscopy during evaluation chronic abdominal pain. The authors assessed appearance stomach, noting those patients gastritis. Urease activity gastric mucosal biopsies was measured. With histologic examination, presence and density H....
Background: In most instances, constipation is considered idiopathic or functional. The total and segmental colonic transit time, traced by radio-opaque markers, makes possible the identification of colon segment that has motility alteration causes constipation. Methods: A study was performed 13 adolescents, aged 12 to 18, with functional chronic without all them times were measured markers. adolescents ingested 20 markers each on three successive days, fourth day a plain abdominal...
The C/T-13910 mutation is the major factor responsible for persistence of lactase-phlorizin hydrolase (LCT) gene expression. Mutation G/A-22018 appears to be only in co-segregation with C/T-13910. objective present study was assess presence these two mutations Brazilian individuals and without lactose malabsorption diagnosed by hydrogen breath test (HBT). Ten milk-tolerant 10 milk-intolerant underwent HBT after oral ingestion 50 g (equivalent 1 L milk). Analyses were performed using a...
Background: The efficacy of a rotavirus vaccine against severe gastroenteritis when coadministered with routine Expanded Program on Immunization (EPI) vaccines including oral polio (OPV) was evaluated in this study. Methods: Double-blind, randomized (2:1), placebo-controlled study conducted across 6 Latin American countries. Healthy infants (N = 6568) to 12 weeks age received 2 doses RIX4414 or placebo following 0, 1- 2-month schedule. Routine OPV were according local EPI Vaccine (VE) caused...
Background/Aim: The interactions between the gut and liver have been described in progression of non-alcoholic steatohepatitis (NASH). aim this study was to develop an experimental nutritional model NASH simulating metabolic changes occurring humans. Materials Methods: Adult male Sprague Dawley rats were randomized into two groups: controls (standard diet) intervention (high-fat choline-deficient for 16 weeks, each group with 10 animals. Biochemical analysis, hepatic lipid content,...
To evaluate the effects of chronic exposure to ethanol in liver and expression inflammatory genes zebrafish.Zebrafish (n = 104), wild type, adult, male female, were divided into two groups: Control (0.05 v/v). The was directly added water; tanks water changed every days replaced. animals fed twice a day with fish food until satiety. After four weeks trial, livers dissected, histological analysis (hematoxilin-eosin Oil Red staining) gene assessment adiponectin, adiponectin receptor 2...
This large study with a long-term follow-up aimed to evaluate the clinical presentation, laboratory findings, histological profile, treatments, and outcomes of children adolescents autoimmune hepatitis.The medical records 828 hepatitis were reviewed. A questionnaire was used collect anonymous data on biochemical treatments.Of all patients, 89.6% had hepatitis-1 10.4% hepatitis-2. The female sex predominant in both groups. median age at symptom onset 111.5 (6; 210) 53.5 (8; 165) months...
Background Acute hepatitis A superimposed on chronic liver disease has been associated with a more severe course of and development fulminant hepatitis. The aim this study was to evaluate the immunogenicity safety an inactivated virus vaccine in children disease. Patients Methods This open, prospective, controlled trial 89 anti-HAV negative between 1 16 years age studied at pediatric transplantation referral center. Inactivated HAV (Havrix), from GlaxoSmithKline Biologicals containing 720...
To determine the prevalence of spontaneous bacterial peritonitis, ascites with infection and noninfected in pediatric patients portal hypertensive to compare clinical laboratory features infected ascites.Forty-one episodes (serum-ascites albumin gradient >1.1 g/dL) 31 were studied. Median age was 2.9 years. Twenty-four (77.4%) cirrhotic 20 (83.3%) classified as Child-Pugh C. end-stage liver disease score 18.5. The following assessed: polymorphonuclear neutrophil cell count, cytology, pH,...
OBJECTIVE: We evaluated the seroprevalence for measles, mumps, and rubella in school-age children (6-12 years old) before after administration of three triple combined viral vaccines. METHODS: In two municipal schools Rio Grande do Sul, Brazil, 692 blood samples were collected vaccination 636 21 to 30 days during 1996. IgG antibody seropositivity was investigated by enzyme-linked immunosorbent assay (measles mumps with Enzygnost [Behring, Marburg, Germany]; Rubenostika [Organon Teknica,...
We retrospectively analysed 33 children and adolescents who had been hospitalized in a liver transplant unit within the previous 10 years for acute failure (ALF). The patients' age varied between 2 months 15 of (median 6.2 +/- 5.3), 21 (63%) were male. Thirteen patients (39%) immunoglobulin-M anti-hepatitis A virus (HAV) sero-positive. Eleven cases (33%) an undetermined aetiology. 13 with HAV ALF 17 15.6 5.8 4.6) eight male (61.5%). All on list urgent transplant. Of these, five (38%) died...
Abstract Background Undernutrition is a common problem among children with congenital heart disease (CHD) and may lead to poorer surgical outcomes. A higher intake of energy during the postoperative period CHD surgery seems be associated better This study aimed investigate effect use energy‐enriched formula (EE‐formula) compared normocaloric 30 days after surgery. Methods randomized controlled trial patients undergoing in tertiary hospital southern Brazil from March 2017 December was...
Hepatitis A vaccine has not been investigated in children with Down syndrome. The aim of this study was to evaluate immunogenicity and safety an inactivated hepatitis noninstitutionalized syndrome compare their responses those healthy control children.An open, prospective, controlled trial 127 ages 1 12 years, 63 64 subjects, conducted at a single hospital. Inactivated virus (HAV) containing 720 enzyme-linked immunosorbent assay units alum-adsorbed HAV administered intramuscularly two-dose...
In biliary atresia (BA), a cholangiopathy of elusive etiology invariably leads to cirrhosis, and disturbed angiogenesis may be involved. We evaluated the hepatobiliary immunolocalization vascular endothelial growth factor (VEGF) A, VEGF receptor 1 (R1), R2 in BA. analyzed biopsies obtained at portoenterostomy from infants with BA (n=52), including embryonic (n=14) perinatal (n=38) types. Controls were intrahepatic cholestasis (IC; n=7). BA, A was also explants (n=33) porta hepatis (n=16)....
Abstract Background Biliary atresia (BA) includes a sclerosing cholangiopathy whose nature is not fully deciphered. Aiming to evaluate the role of an arteriopathy as etiologic factor in BA, we investigated hypoxia and correlated angiogenic response livers from affected patients. Methods Gene expression molecular axis: hypoxia‐inducible ( HIF ) 1a , HIF2a vascular endothelial growth A VEGFA )/ VEGFR1 VEGFR2 . Liver biopsy specimens collected at exploratory laparotomy age‐matched patients with...
To evaluate 16S ribosomal RNA (rRNA) gene amplification to diagnose spontaneous bacterial peritonitis (SBP).According a retrospective protocol, 31 patients with portal hypertensive ascites (serum albumin gradient > or = 1.1 g/dL) were studied. Ascitic fluid was analyzed as follows: Gram stain, aerobic and anaerobic cultures, polymorphonuclear cell count, biochemical tests. Bacterial DNA detected by polymerase chain reaction.There 8 episodes of SBP 4 bacterascites (BA). Culture positive in...
OBJETIVO: Apresentar uma revisão atualizada e crítica da prevenção das hepatites virais A B, através de imunização. FONTE DOS DADOS: Revisão artigos médicos obtidos do banco dados MEDLINE, sendo selecionados os mais atuais representativos tema (2000-2006). Foram também pesquisados sites Centers for Disease Control and Prevention (CDC) American Academy of Pediatrics (AAP), Sociedade Brasileira Pediatria (SBP) Ministério Saúde Brasil. SÍNTESE é um enorme desafio para o sistema saúde pública...