A5081386038- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Hedgehog Signaling Pathway Studies
- Adipose Tissue and Metabolism
- Liver physiology and pathology
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and disorders
- Celiac Disease Research and Management
- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Folate and B Vitamins Research
- Hepatitis B Virus Studies
- Gut microbiota and health
- Pediatric Hepatobiliary Diseases and Treatments
- Lipid metabolism and biosynthesis
- Gastrointestinal disorders and treatments
- Liver Diseases and Immunity
- Parasites and Host Interactions
- Cancer, Hypoxia, and Metabolism
University of Lisbon
2012-2024
Hospital Vila Franca de Xira
2020-2024
Hospital de Santa Maria
2012-2021
Centro Hospitalar Lisboa Norte
2016-2021
Instituto Nacional do Câncer
2021
Luzerner Kantonsspital
2020
University of Bern
2020
Duke Medical Center
2013-2018
Duke University
2012-2017
Duke University Hospital
2015
Several animal studies have emphasized the role of gut microbiota in nonalcoholic fatty liver disease (NAFLD). However, data about dysbiosis human NAFLD remain scarce literature, especially including whole spectrum lesions. We aimed to evaluate association between and severe lesions, that is, steatohepatitis (NASH) fibrosis, a well-characterized population adult NAFLD. Fifty-seven patients with biopsy-proven were enrolled. Taxonomic composition was determined using 16S ribosomal RNA gene...
Background and aims Non-alcoholic steatohepatitis (NASH), the potentially progressive form of nonalcoholic fatty liver disease (NAFLD), is pandemic our time. Although there are several animal models NASH, consensus regarding optimal model lacking. We aimed to compare features NASH in two most widely-used mouse models: methionine-choline deficient (MCD) diet Western diet. Methods Mice were fed standard chow, MCD for 8 weeks, or (45% energy from fat, predominantly saturated with 0.2%...
Recent evidence has linked obesity and the metabolic syndrome with gut dysbiota. The precise mechanisms underlying that association are not entirely understood; however, microbiota can enhance extraction of energy from diet regulate whole-body metabolism towards increased fatty acids uptake adipose tissue shift lipids oxidation to de novo production. Obesity high fat relate a specific microbiota, which is enriched in Firmicutes less Bacterioidetes. Microbiota also play role development...
Smoothened (SMO), a coreceptor of the Hedgehog (Hh) pathway, promotes fibrogenic repair chronic liver injury. We investigated roles SMO+ myofibroblast (MF) in regeneration by conditional deletion SMO α smooth muscle actin (αSMA)+ cells after partial hepatectomy (PH).αSMA-Cre-ER(T2)×SMO/flox mice were treated with vehicle (VEH) or tamoxifen (TMX), and sacrificed 24-96 h post-PH. Regenerating livers analysed for proliferation, progenitors fibrosis qRT-PCR quantitative immunohistochemistry...
Abstract microRNAs were recently suggested to contribute the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a lacking specific pharmacological treatments. In that regard, nuclear receptors are arising as key molecular targets for treatment steatohepatitis (NASH). Here we show that, in typical model NASH-associated damage, microRNA-21 (miR-21) ablation results progressive decrease steatosis, inflammation and lipoapoptosis, with impairment fibrosis. complementary fast food (FF) diet...