A5013924852- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Marine Sponges and Natural Products
- Pneumonia and Respiratory Infections
- Hepatitis Viruses Studies and Epidemiology
- Trypanosoma species research and implications
- Bacterial Infections and Vaccines
- Research on Leishmaniasis Studies
- Toxoplasma gondii Research Studies
- Animal Virus Infections Studies
- Traditional and Medicinal Uses of Annonaceae
- Parasitic Infections and Diagnostics
- Microbial Natural Products and Biosynthesis
- Respiratory viral infections research
- Synthesis and Biological Activity
- Phytochemical compounds biological activities
- Zoonotic diseases and public health
- Herpesvirus Infections and Treatments
- Toxin Mechanisms and Immunotoxins
- Vaccine Coverage and Hesitancy
- Insect Pest Control Strategies
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Cytomegalovirus and herpesvirus research
- Streptococcal Infections and Treatments
Secretaría Nacional de Ciencia, Tecnología e Innovación
2005-2022
City of Knowledge
2003-2021
MSD (Mexico)
2021
GlaxoSmithKline (India)
2011-2020
Takeda (United States)
2017
United States Patent and Trademark Office
2017
GlaxoSmithKline (Brazil)
2008-2016
Secretaria da Saúde
2016
Instituto Evandro Chagas
2016
Ministério da Saúde
2016
The safety and efficacy of an attenuated G1P[8] human rotavirus (HRV) vaccine were tested in a randomized, double-blind, phase 3 trial.We studied 63,225 healthy infants from 11 Latin American countries Finland who received two oral doses either the HRV (31,673 infants) or placebo (31,552 at approximately months four age. Severe gastroenteritis episodes identified by active surveillance. severity disease was graded with use 20-point Vesikari scale. Vaccine evaluated subgroup 20,169 (10,159...
The relationship between pneumococcal conjugate vaccine-induced antibody responses and protection against community-acquired pneumonia (CAP) acute otitis media (AOM) is unclear. This study assessed the impact of ten-valent nontypable Haemophilus influenzae protein D vaccine (PHiD-CV) on these end points. primary objective was to demonstrate efficacy (VE) in a per-protocol analysis likely bacterial CAP (B-CAP: radiologically confirmed with alveolar consolidation/pleural effusion chest X-ray,...
Coibamide A (1) is a new, potent antiproliferative depsipeptide which was isolated from marine Leptolyngbya cyanobacterium collected the Coiba National Park, Panama. The planar structure of 1 elucidated by combination NMR spectroscopy and mass spectrometry. Exhaustive 1D 2D included natural abundance 15N variable temperature experiments; spectrometry TOF-ESI-MSn FT-MSn experiments. Chemical degradation followed chiral HPLC- GC-MS analyses used to assign absolute configuration 1. This highly...
Two new modified cyclic hexapeptides, venturamides A (1) and B (2), were isolated from the marine cyanobacterium Oscillatoria sp. by antimalarial bioassay-guided fractionation. The isolation of 1 2 represents first example identification cyanobacterial peptides with selective activity. planar structures determined 1D 2D NMR analyses and, in case venturamide (1), comparison literature data for a previously reported synthetic compound. absolute configuration amino acid residues was hydrolysis...
As part of the Panama International Cooperative Biodiversity Groups (ICBG) project, two new (2, 4) and known (1, 3) linear alkynoic lipopeptides have been isolated from a Panamanian strain marine cyanobacterium Lyngbya majuscula. Carmabin A (1), dragomabin (2), dragonamide (3) showed good antimalarial activity (IC50 4.3, 6.0, 7.7 μM, respectively), whereas nonaromatic analogue, B (4), was inactive. The planar structures all four compounds were determined by NMR spectroscopy in combination...
Background: Mexico initiated mass vaccination with the attenuated human rotavirus vaccine (Rotarix) in 2006. This postlicensure study aimed to assess any potential temporal association between and intussusception Mexican infants. Methods: Prospective, active surveillance for among infants aged less than 1 year was conducted 221 hospitals across from Institute of Social Security January 2008 October 2010. The assessed by self-controlled case-series analysis. Results: Of 753 episodes reported...
ABSTRACT Proteins with constitutive or transient localization on the surface of Apicomplexa parasites are particular interest for their potential role in invasion host cells. We describe identification and characterization TgAMA1, Toxoplasma gondii homolog Plasmodium apical membrane antigen 1 (AMA1), which has been shown to elicit a protective immune response against merozoites dependent correct pairing its numerous disulfide bonds. TgAMA1 shows between 19% ( berghei ) 26% yoelii overall...
Trypanosoma cruzi expresses a developmentally regulated neuraminidase (TCNA) implicated in parasite invasion of cells. We isolated full-length DNA clones encoding TCNA. Sequence analysis demonstrated an open reading frame coding for polypeptide 1,162 amino acids. In the N-terminus there is cysteine-rich domain containing stretch 332 acids nearly 30% identical to Clostridium perfringens neuraminidase, three repeat motifs highly conserved bacterial and viral neuraminidases, two segments with...
Parallel chemical and phylogenetic investigation of a marine cyanobacterium from Panama led to the isolation two new PKS-NRPS-derived compounds, viridamides A B. Their structures were determined by NMR mass spectroscopic methods, absolute configurations assigned Marfey’s method chiral HPLC analysis. In addition six standard, N-methylated amino hydroxy acids, these metabolites contained structurally novel 5-methoxydec-9-ynoic acid moiety an unusual proline methyl ester terminus....
Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure based on previously undescribed tricyclo[9.3.0.02,10]tetradecane ring system that was established through spectroscopic analysis and X-ray crystallographic analysis. shown to exhibit antimalarial activity against Plasmodium falciparum as well strong anticancer two human cancer cell lines.
Background: Brazil initiated universal immunization of infants with the G1P[8] human rotavirus (RV) vaccine in March 2006. This study evaluated effectiveness (VE) against severe gastroenteritis (RVGE) hospitalizations. Methods: Matched case-control conducted at 4 hospitals Belém from May 2008 to 2009. Cases were children hospitalized RVGE age-eligible have received 2 doses RV (≥12 weeks age and born after 6, 2006). For each case, 1 neighborhood hospital control without was selected, matching...
Rotavirus vaccination was introduced in Brazil March 2006, targeting an annual birth cohort of approximately 3.5 million. We analyzed trends all-cause gastroenteritis-related deaths children <5 years age during the pre- and post-vaccination periods.Data from National Immunization Program Mortality Information System were used to calculate vaccine coverage mortality rates related gastroenteritis <1 year 1-4 age, using population estimates census as denominator. Relative reductions calculated...
Toxoplasma gondii is one of the most widespread parasites humans and animals. The parasite has a remarkable ability to invade broad range cells within its mammalian hosts by mechanisms that are poorly understood at molecular level. This host cell specificity suggests adhesion should involve recognition ubiquitous surface-exposed molecules or, alternatively, presence various attachment able recognize different receptors. We have discovered sugar-binding activity (lectin) in tachyzoites ofT....
Toxoplasma gondii has recently come under intense study as a model for intracellular parasitism because it number of properties that facilitate experimental manipulation. Attention is now being turned towards understanding the developmental biology this complex parasite. The differentiation between two asexual stages, rapidly growing tachyzoites and more slowly dividing, encysted bradyzoites, particular interest. Progression from former to latter influenced by host's immune response. This...
Transmission of excreted vaccine-derived infectious virus from vaccinated to unvaccinated individuals is possible within close contacts. This randomized (1:1), double-blind study evaluated the potential for transmission human rotavirus vaccine strain, HRV (Rotarix™) recipients contacts (twins). 100 pairs healthy twins aged 6-14 weeks at time Dose 1 vaccine/placebo were enrolled and one randomly selected twin each pair received two doses other placebo (at 2 4 months age). Presence strain in...
The ability of the Lyme disease spirochete to attach host components may contribute its infect diverse tissues. We present evidence that expresses a lectin activity promotes agglutination erythrocytes and bacterial attachment glycosaminoglycans. Among collection 21 strains spirochete, hemagglutinating was easily detected in all but 3 strains, these three were noninfectious. agglutinate associated with bind sulfated polysaccharide dextran sulfate mammalian cells. Soluble potent inhibitor both...
As part of an ongoing program to explore the chemical constituents Caribbean marine invertebrates, a family 13 new diterpene glycosides, pseudopterosins P−Z (1−11) and seco-pseudopterosins H (12) I (13), have been isolated from organic extracts two collections sea whip Pseudopterogorgia elisabethae procured near Colombian Southwestern Sea. The structures compounds 1−13, including absolute stereochemistry, proposed on basis comprehensive spectral analyses, transformations, specific rotation,...
Rotavirus vaccination was introduced in Brazil March 2006. We describe trends hospitalizations from all-cause gastroenteritis children younger than 5 years during pre- and postvaccination periods using hospital discharge data Hospital Information System (SIH-SUS). A reduction of 26% 48% 2006 2007, respectively, observed among 1 year compared with prevaccination period (1998–2005). The largest rates were noted the South Southeast regions, approximately 56% where vaccine coverage highest.