A5100434072- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Chronic Kidney Disease and Diabetes
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Acute Kidney Injury Research
- Thyroid Cancer Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Immune cells in cancer
- Cancer Mechanisms and Therapy
Nantong University
2019-2025
Shanghai Ninth People's Hospital
2013-2025
Shanghai Jiao Tong University
2014-2025
Affiliated Zhongshan Hospital of Dalian University
2023-2025
First Affiliated Hospital of Zhengzhou University
2024-2025
Second People's Hospital of NanTong
2025
Second Affiliated Hospital of Nantong University
2025
Zhongda Hospital Southeast University
2016-2025
Hospital of Hebei Province
2025
Hebei Medical University
2009-2025
The diagnosis of myoepithelial (ME) tumors outside salivary glands remains challenging, especially in unusual clinical presentations, such as bone or visceral locations. A few reports have indicated EWSR1 gene rearrangement soft tissue ME tumors, and, one case each, the fusion partner was identified either PBX1 ZNF444. However, larger studies to investigate whether these genetic abnormalities are recurrent restricted locations lacking. Sixty-six mainly from (71%), but also skin, bone, and...
Abstract The BRAFT1799A mutation is the most common genetic alteration in papillary thyroid carcinomas (PTC). It also found a subset of microcarcinomas, consistent with role tumor initiation. PTCs are often invasive and present at more advanced stage. high prevalence tall-cell variant poorly differentiated undifferentiated arising from PTCs. To explore BRAFV600E cancer pathogenesis, we targeted its expression to cells transgenic FVB/N mice bovine thyroglobulin promoter. Two Tg-BRAFV600E...
Abstract Hyalinizing clear‐cell carcinoma (HCCC) is a rare, low‐grade salivary gland tumor with distinctive morphology and pattern of hyalinization as well focal mucinous differentiation. However, histological overlap exists other tumors, such epithelial–myoepithelial (EMCa), myoepithelial carcinoma, mucoepidermoid (MEC). The potential relationship between HCCC its morphological mimics has not been yet investigated at the genetic level. In this study, we conducted molecular analysis for...
Abstract With the application and development of high-throughput sequencing technology in life health sciences, massive multi-omics data brings problem efficient management utilization. Database biocuration are prerequisites for reuse these big data. Here, relying on China National GeneBank (CNGB), we present CNGB Sequence Archive (CNSA) archiving omics data, including raw its further analyzed results which organized into six objects, namely Project, Sample, Experiment, Run, Assembly...
Abstract Primitive round cell sarcomas of childhood and young adults have been problematic to diagnose classify. Our goal was investigate the pathologic molecular characteristics small blue tumors (SBRCT) that remained unclassified after exhaustive immunohistochemistry screening exclude known sarcoma‐related translocations. As rare examples EWSR1 ‐negative SBRCT shown carry rearrangements for FUS CIC genes, we undertook a systematic these two genes. by FISH were detected in 15/22 (68%),...
BCOR - CCNB3 sarcoma (BCS) is a recently defined genetic entity among undifferentiated round cell sarcomas, which was initially classified as and treated similarly to the Ewing (ES) family of tumors. In contrast ES, BCS shows consistent overexpression, preliminary evidence suggests that these tumors share morphologic features with other harboring alterations, including internal tandem duplication (ITD) BCOR-MAML3 . To further investigate pathologic features, clinical behavior, their...
Round cell sarcomas harboring CIC‐DUX4 fusions have recently been described as highly aggressive soft tissue tumors of children and young adults. Due to partial morphologic immunohistochemical overlap with Ewing sarcoma (ES), ‐positive generally classified ES‐like managed similarly; however, a systematic comparison at the molecular levels between these two groups has not yet conducted. Based on an initial observation that show nuclear immunoreactivity for WT1 ETS transcription factors, FLI1...
Abstract Spindle cell rhabdomyosarcoma (RMS) is a rare form of RMS with different clinical characteristics between children and adult patients. Its genetic hallmark remains unknown it debatable if there pathogenetic relationship the spindle so‐called sclerosing RMS. We studied two pediatric one by next generation RNA sequencing FusionSeq data analysis to detect novel fusions. An SRF‐NCOA2 fusion was detected in from posterior neck 7‐month‐old child. The matched tumor karyotype confirmed FISH...
Colon cancer (CC) is a common malignant cancer. Recently, circFNDC3B was found to exert biological function in multiple cancers. However, it unclear whether the potential protein encoded by involved carcinogenesis of CC.We used Sanger sequence and RNase R digestion assay confirm existence circFNDC3B, quantitative real-time PCR evaluate circRNA's expression. Then fluorescence situ hybridization (FISH) performed study location circFNDC3B. The identification using LC-MS/MS. circFNDC3B-218aa on...
Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein, but its role in modulating macrophage-related inflammation during liver fibrosis has not been documented. Herein, we aimed to characterise the roles of macrophage FSTL1 development fibrosis.Expression analysis was conducted with human samples obtained from 33 patients and 18 individuals without serving controls. Myeloid-specific FSTL1-knockout (FSTL1M-KO) mice were constructed explore function mechanism 3...
Most breast cancers at an advanced stage exhibit aggressive nature, and there is a lack of effective anticancer options. Herein, the development patient-derived organoids (PDOs) described as real-time platform to explore feasibility tailored treatment for refractory cancers. PDOs are successfully generated from cancer tissues, including heavily treated specimens. The microtubule-targeting drug-sensitive response signatures predict improved distant relapse-free survival invasive with adjuvant...
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis and destruction of cartilage, promoted sustained inflammation. However, current treatments remain unsatisfactory due to lacking selective effective strategies for alleviating environments in RA joint. Inspired neutrophil chemotaxis region, we therefore developed neutrophil-derived exosomes functionalized with sub-5 nm ultrasmall Prussian blue nanoparticles (uPB-Exo) via click chemistry, inheriting...
Senescent mandibular bone repair poses a formidable challenge without completely satisfactory strategy. Endogenous cell recruitment and osteogenic differentiation are two sequential stages in regeneration, disruptions these processes present significant obstacles to senescent repair. To address issues, engineered extracellular vesicles (EV) with stem functions were developed. This study demonstrated that Apt19s-engineered (Apt19s-EV) recognize recruit marrow mesenchymal cells derived from...
We have mapped conserved regions of enhanced DNase I accessibility within the endogenous chromosomal locus vascular endothelial growth factor A (VEGF-A). Synthetic zinc finger protein (ZFP) transcription factors were designed to target DNA sequences contained I-hypersensitive regions. These ZFPs, when fused either VP16 or p65 transcriptional activation domains, able activate expression VEGF-A gene as assayed by mRNA accumulation and secretion through a range exceeding that induced hypoxic...
Abstract With the development of new advances in hepatocellular carcinoma ( HCC ) management and noninvasive radiological techniques, high‐risk patient groups such as those with hepatitis virus are closely monitored. is increasingly diagnosed early, treatment may be successful. In spite this progress, most patients who undergo a hepatectomy will eventually relapse, outcomes remain unsatisfactory. our study, we aimed to identify potential gene biomarkers based on RNA sequencing data predict...
Abstract Circular RNAs (circRNAs), a new class of regulatory noncoding RNAs, play important roles in human diseases. While growing number circRNAs have been characterized with biological functions, it is necessary to integrate all the information facilitate studies on circRNA functions and networks Circ2Disease database contains 273 manually curated associations between 237 54 diseases strong experimental evidence from 120 studies. Each association includes name, disease expression pattern,...
Polymorphous low-grade adenocarcinoma (PLGA) and cribriform of minor salivary gland (CAMSG) are carcinomas arising most often in oral cavity oropharynx, respectively. Controversy exists as to whether these tumors represent separate entities or variants one spectrum, they appear have significant overlap, but also clinicopathologic differences. As many harbor recurrent translocations, paired-end RNA sequencing FusionSeq data analysis was applied for novel fusion discovery on two CAMSGs PLGAs....
Abstract Despite their shared predilection for superficial soft tissue of distal extremities and frequent local recurrences, myxoinflammatory fibroblastic sarcoma (MIFS) hemosiderotic fibrolipomatous tumor (HFLT) have distinct morphologic appearances. Recent studies identified an identical t(1;10)(p22;q24) in five cases MIFS two HFLT, as well common amplifications on 3p11‐12. To investigate further potential relationship to determine the incidence t(1;10) a larger cohort, we subjected seven...
Sclerosing and spindle cell rhabdomyosarcoma (RMS) are rare types of RMS recently reclassified as a stand‐alone pathologic entity, separate from embryonal (ERMS). Although sclerosing share clinical morphologic features, pathogenetic link based on shared molecular alterations has not been established. Spindle in children have associated with less aggressive course compared to adults. Recently, recurrent MYOD1 mutations were described 44% adult RMS, but no pediatric tumors or studied for...
Many intrinsic and extrinsic factors can affect an individual patient's drug exposure response. The US Food Drug Administration (FDA) has published a number of guidances that recommend how when to evaluate these during development. most recent FDA draft guidance on interactions provides advice for in vitro vivo interaction studies, including suggestions study design, dosing strategies analysis, interpretation data medical product labels. updated the FDA's recommendations evaluation important...
A subset of cutaneous and superficial soft tissue myoepithelial (ME) tumors displays a distinct ductal component closely resembles mixed tumors/pleomorphic adenomas salivary gland. As PLAG1 HMGA2 rearrangements are the most common genetic events in pleomorphic adenomas, we sought to investigate if these abnormalities also present skin/soft ME lesions. In contrast, half deep‐seated lacking differentiation known be genetically unrelated, showing EWSR1 rearrangements. FISH analysis detect was...