A5056955251- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Head and Neck Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Tumors and Oncological Cases
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Cytokine Signaling Pathways and Interactions
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Cancer and Skin Lesions
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Medical Imaging and Pathology Studies
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
University of Pittsburgh Medical Center
2016-2025
University of Pittsburgh
2016-2025
UPMC Hillman Cancer Center
2006-2025
UPMC Presbyterian
2015-2025
Yale New Haven Hospital
2024
Cleveland Clinic
2009-2021
Merck & Co., Inc., Rahway, NJ, USA (United States)
2021
MSD K.K. (Japan)
2021
Bristol-Myers Squibb (Germany)
2021
Johnson & Johnson (Israel)
2021
Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs. The majority exhibited profile consistent with tobacco exposure; human papillomavirus was detectable by DNA infected tumors. In addition to identifying previously known HNSCC genes (TP53, CDKN2A, PTEN, PIK3CA, HRAS), our analysis revealed many not implicated in this At least 30% of cases...
Although growing evidence points to highly indolent behavior of encapsulated follicular variant papillary thyroid carcinoma (EFVPTC), most patients with EFVPTC are treated as having conventional cancer.To evaluate clinical outcomes, refine diagnostic criteria, and develop a nomenclature that appropriately reflects the biological characteristics EFVPTC.International, multidisciplinary, retrospective study nodules diagnosed EFVPTC, including 109 noninvasive observed for 10 26 years 101...
Thyroid nodules are common in adults, but only a small fraction of them is malignant. Fine-needle aspiration (FNA) cytology provides definitive diagnosis benign or malignant disease many cases, whereas about 25% indeterminate, hindering most appropriate management.The objective the investigation was to study clinical utility molecular testing thyroid FNA samples with indeterminate cytology.Residual material from 1056 consecutive used for prospective analysis that included assessment cell...
Context Human papillomavirus (HPV) is a major cause of oropharyngeal squamous cell carcinomas, and HPV (and/or surrogate marker p16) status has emerged as prognostic that significantly impacts clinical management. There no current consensus on when to test carcinomas for HPV/p16 or which tests choose. Objective To develop evidence-based recommendations the testing, application, interpretation, reporting in head neck carcinomas. Design The College American Pathologists convened panel experts...
BACKGROUND Fine‐needle aspiration (FNA) cytology is a common approach to evaluating thyroid nodules, although 20% 30% of FNAs have indeterminate cytology, which hampers the appropriate management these patients. Follicular (or oncocytic) neoplasm/suspicious for follicular neoplasm (FN/SFN) diagnosis with cancer risk approximately 15% 30%. In this study, authors tested whether most complete next‐generation sequencing (NGS) panel genetic markers could significantly improve in nodules. METHODS...
<h3>Importance</h3> Approximately 20% of fine-needle aspirations (FNA) thyroid nodules have indeterminate cytology, most frequently Bethesda category III or IV. Diagnostic surgeries can be avoided for these patients if the are reliably diagnosed as benign without surgery. <h3>Objective</h3> To determine diagnostic accuracy a multigene classifier (GC) test (ThyroSeq v3) cytologically nodules. <h3>Design, Setting, and Participants</h3> Prospective, blinded cohort study conducted at 10 medical...
Abstract Hyalinizing clear‐cell carcinoma (HCCC) is a rare, low‐grade salivary gland tumor with distinctive morphology and pattern of hyalinization as well focal mucinous differentiation. However, histological overlap exists other tumors, such epithelial–myoepithelial (EMCa), myoepithelial carcinoma, mucoepidermoid (MEC). The potential relationship between HCCC its morphological mimics has not been yet investigated at the genetic level. In this study, we conducted molecular analysis for...
Background: Fine-needle aspiration (FNA) cytology is a common approach to evaluate thyroid nodules. It offers definitive diagnosis of benign or malignant nodule in the majority cases. However, 10–25% nodules yield one three indeterminate cytologic diagnoses, leading suboptimal management these patients. Atypia undetermined significance/follicular lesion undermined significance (AUS/FLUS) diagnosis, with cancer risk ranging from 6% 48%. This study assessed whether multi-gene next-generation...
Despite evidence implicating transcription factors, including STAT3, in oncogenesis, these proteins have been regarded as "undruggable." We developed a decoy targeting STAT3 and conducted phase 0 trial. Expression levels of target genes were decreased head neck cancers following injection with the compared tumors receiving saline control. Decoys not amenable to systemic administration due instability. To overcome this barrier, we linked oligonucleotide strands using hexaethylene glycol...
Many cancer types, including head and neck cancers (HNC), express programmed death ligand 1 (PD-L1). Interaction between PD-L1 its receptor, (PD-1), inhibits the function of activated T cells results in an immunosuppressive microenvironment, but stimuli that induce expression are not well characterized. Interferon gamma (IFNγ) epidermal growth factor receptor (EGFR) utilize Janus kinase 2 (JAK2) as a common signaling node to transmit tumor cell-mediated extrinsic or intrinsic signals,...
The MECT1/MAML2 translocation is identified in a large proportion of mucoepidermoid carcinomas (MEC) the salivary gland and an emerging favorable prognosticator. However, there are conflicting data on this translocation's specificity, restriction to low/intermediate MEC, strength as We present our experience with cohort MECs address these issues. analyzed 55 MEC 36 potential mimics (24 Warthin tumors, 5 oncocytomas, 3 squamous cell carcinomas, 2 squamoid duct 1 lymphoepithelial cyst,...
PURPOSE To provide evidence-based recommendations for practicing physicians and other healthcare providers on the management of salivary gland malignancy. METHODS ASCO convened an Expert Panel medical oncology, surgical radiation neuroradiology, pathology, patient advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, prospective retrospective comparative observational studies published from 2000 through 2020. Outcomes...
"Follicular lesion of undetermined significance/atypia significance" is a heterogeneous category cases that cannot be classified into 1 the other established categories. The use ancillary molecular studies has not been widely explored for this diagnosis.All thyroid cytology diagnosed as follicular significance were retrieved from April 2007 to December 2008. During time period, samples collected routinely at aspiration cytologic and studies. Analysis BRAF RAS gene mutations RET/PTC...
Chiosea S I, Griffith C, Assaad A & Seethala R (2012) Histopathology 61, 387–394 Clinicopathological characterization of mammary analogue secretory carcinoma salivary glands Aims: Mammary (MASC) is a recently described tumour with ETV6 translocation. We aimed to characterize the clinical significance recognizing MASC. Methods and results: Thirty‐six patients MASC (27 identified retrospectively nine prospectively) are presented. Historically, mimicked other tumours, as follows: 14 37...
A study from the international multidisciplinary group, published in April 2016, proposed reclassification of a type lowrisk thyroid cancer as noninvasive follicular neoplasm with papillarylike nuclear features (NIFTP), eliminating term tumor name. 1 Since then, new has been recommended for use by many professional societies and included entity WHO Classification Tumours Endocrine Organs World Health Organization 2017.Over course 18 months, more than 80 peer-reviewed publications have...
Importance Accurate staging is a fundamental step in treating patients with nasopharyngeal carcinoma (NPC) worldwide; this crucial not only for prognostication, but also guiding treatment decisions. The American Joint Committee on Cancer (AJCC)/Union International Control (UICC) tumor-node-metastasis (TNM) system the global language clinicians, researchers, and cancer registries. Continual improvement that aligns contemporary pattern of care essential. Objective To improve prognostic...
We determined hepatocyte growth factor (HGF) and c-Met expression signaling in human head neck squamous cell carcinoma (HNSCC) cells primary tissues tested the ability of tyrosine kinase inhibitors (TKI) to block HGF-induced biological signaling.Expression were using immunoblotting, ELISA, immunohistochemistry. Biological end points included wound healing, proliferation, invasion. TKIs for their effects vitro xenografts established nude mice.c-Met was expressed functional HNSCC cells. HGF...