A5036101346- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Ear and Head Tumors
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- NF-κB Signaling Pathways
- Colorectal Cancer Treatments and Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
University of Hong Kong - Shenzhen Hospital
2015-2025
University of Hong Kong
2016-2025
Chinese University of Hong Kong
2009-2025
Queen Elizabeth Hospital
2000-2023
Pamela Youde Nethersole Eastern Hospital
2013-2022
Hong Kong Sanatorium and Hospital
2020-2022
Queen Mary Hospital
2010-2022
University Grants Committee
2018-2021
GTx (United States)
2020
Tuen Mun Hospital
2010-2018
Purpose The role of adjuvant chemotherapy (AC) or induction (IC) in the treatment locally advanced nasopharyngeal carcinoma is controversial. individual patient data from Meta-Analysis Chemotherapy Nasopharynx Carcinoma database were used to compare all available treatments. Methods All randomized trials radiotherapy (RT) with without nonmetastatic considered. Overall, 20 and 5,144 patients included. Treatments grouped into seven categories: RT alone (RT), IC followed by (IC-RT), AC (RT-AC),...
Current practice of adding concurrent–adjuvant chemotherapy to radiotherapy (CRT) for treating advanced nasopharyngeal carcinoma is based on the Intergroup-0099 Study published in 1998. However, outcome radiotherapy-alone (RT) group that trial was substantially poorer than those other trials, and there were no data late toxicities. Verification long-term therapeutic index this regimen needed. Patients with nonkeratinizing staged T1-4N2-3M0 randomly assigned RT (176 patients) or CRT (172...
An accurate staging system is crucial for cancer management. Evaluations continual suitability and improvement are needed as treatment methods evolve.This was a retrospective study of 1609 patients with nasopharyngeal carcinoma investigated by magnetic resonance imaging, staged the 7th edition American Joint Committee on Cancer (AJCC)/International Union Against (UICC) system, irradiated intensity-modulated radiotherapy at 2 centers in Hong Kong mainland China.Among without other T3/T4...
The 2019 novel coronavirus disease (COVID-19) is a highly contagious zoonosis produced by SARS-CoV-2 that spread human-to-human respiratory secretions. It was declared the WHO as public health emergency. most susceptible populations, needing mechanical ventilation, are elderly and people with associated comorbidities. There an important risk of contagion for anesthetists, dentists, head neck surgeons, maxillofacial ophthalmologists, otolaryngologists. Health workers represent between 3.8%...
Purpose The contribution of adjuvant chemotherapy after chemoradiation therapy (CRT) in nasopharyngeal cancer (NPC) remains controversial. Plasma Epstein-Barr virus (EBV) DNA is a potential biomarker subclinical residual disease NPC. In this prospective, multicenter, randomized controlled trial, we used plasma EBV to identify patients with NPC at higher risk relapse for chemotherapy. Patients and Methods Eligible histologically confirmed Union International Cancer Control stage IIB IVB,...
Importance Accurate staging is a fundamental step in treating patients with nasopharyngeal carcinoma (NPC) worldwide; this crucial not only for prognostication, but also guiding treatment decisions. The American Joint Committee on Cancer (AJCC)/Union International Control (UICC) tumor-node-metastasis (TNM) system the global language clinicians, researchers, and cancer registries. Continual improvement that aligns contemporary pattern of care essential. Objective To improve prognostic...
Purpose. This phase II, open-label, multicenter study assessed the oral, multitargeted, tyrosine kinase inhibitor sunitinib in patients with advanced gastric or gastroesophageal junction adenocarcinoma who had received prior chemotherapy. Experimental design. Patients 50 mg/day on Schedule 4/2 (4 weeks treatment, followed by 2 off treatment). The primary endpoint was objective response rate; secondary endpoints included clinical benefit rate, duration of response, progression-free survival...
BACKGROUND A current recommendation for locoregionally advanced nasopharyngeal carcinoma (NPC) is conventional fractionated radiotherapy with concurrent cisplatin plus adjuvant and fluorouracil (PF). In this randomized trial, the authors evaluated potential therapeutic benefit from changing to an induction‐concurrent chemotherapy sequence, replacing oral capecitabine, and/or using accelerated rather than fractionation. METHODS Patients stage III through IVB, nonkeratinizing NPC were randomly...
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy with a unique geographical distribution. The genomic abnormalities leading to NPC pathogenesis remain unclear. In total, 135 tumors were examined characterize the mutational landscape using whole-exome sequencing and targeted resequencing. An APOBEC cytidine deaminase mutagenesis signature was revealed in somatic mutations. Noticeably, multiple loss-of-function mutations identified several NF-κB signaling negative regulators NFKBIA,...
BACKGROUND The objective of this study was to develop a nomogram for refining prognostication patients with nondisseminated nasopharyngeal cancer (NPC) staged the proposed 8th edition American Joint Committee on Cancer (AJCC)/Union International Control (UICC) staging system. METHODS Consecutive who had been investigated magnetic resonance imaging, AJCC/UICC system, and irradiated intensity‐modulated radiotherapy from June 2005 December 2010 were analyzed. A cohort 1197 treated at Fujian...