A5001593340- Ear and Head Tumors
- Cancer and Skin Lesions
- Histiocytic Disorders and Treatments
- NF-κB Signaling Pathways
- Liver Disease Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- interferon and immune responses
- RNA modifications and cancer
- E-commerce and Technology Innovations
- Muscle Physiology and Disorders
- Congenital heart defects research
- Plant Disease Resistance and Genetics
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- AI and Big Data Applications
- Viral-associated cancers and disorders
- AI and Multimedia in Education
University of Hong Kong
2016-2025
Chongqing Technology and Business University
2022
Queen Mary Hospital
2022
Chinese University of Hong Kong
2016
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy with a unique geographical distribution. The genomic abnormalities leading to NPC pathogenesis remain unclear. In total, 135 tumors were examined characterize the mutational landscape using whole-exome sequencing and targeted resequencing. An APOBEC cytidine deaminase mutagenesis signature was revealed in somatic mutations. Noticeably, multiple loss-of-function mutations identified several NF-κB signaling negative regulators NFKBIA,...
Background: Induced pluripotent stem cells induced hepatocytes (iHeps) are widely used in modeling human liver diseases and as a potential cell source for replacement therapy. However, most iHeps relatively immature challenging to maintain long-term vitro culture. Methods: We optimized the differentiation protocol by addition of combination small molecules inhibit epithelial–mesenchymal transition (EMT) (iHeps EMTi), further characterized their function both vivo analyses. Results:...
Nasopharyngeal carcinoma (NPC) is a malignant epithelial of the nasopharynx. Cylindromatosis lysine 63 deubiquitinase (CYLD), NF-kB inhibitor, was reported as one top mutated candidate genes in NPC. an inducible transcription factor, contributing to cancer via regulating inflammation, angiogenesis, cell proliferation, and metastasis. In this study, impact CYLD on signaling pathway its contribution NPC development studied using vitro vivo functional assays, together with single RNA sequencing...
The long non-coding RNA (lncRNA) NKILA, localized to 20q13.31, is a negative regulator of NF-κB signaling implicated in carcinogenesis. As CpG island embedded the promoter region it hypothesized as tumor suppressor lncRNA silenced by DNA methylation non-Hodgkin’s lymphoma (NHL). By pyrosequencing-verified methylation-specific PCR, NKILA was detected 1/10 (10%) NHL cell lines, but not normal peripheral blood buffy coats or tonsils. correlated with repression lines. Hypomethylation treatment...
In the past decade, global recognition of traditional sports intangible cultural heritage (ICH) assets has been increasing. The main purpose this paper is to explore inheritance ICH and construction characteristic physical education (PE) in colleges universities. rapid development wireless communication technology requires digital processors have higher processing efficiency faster response time. application signal equipment, compared with central unit, microprocessor advantages time small...
HCC is characterized by metabolic pathway aberrations, which enable cancer cells to meet their energy demands and accelerate malignant progression. Identifying novel players governing therapy resistance self-renewal in crucial, as these properties are likely responsible for tumor recurrence.
Background: NF-κB is an important signaling pathway for regulating multiple cascades involved in cancer development such as inflammation, immune response, cell survival, and proliferation. Constitutive activation of the plays a key role NPC. Our previous whole-exome sequencing (WES) study NPC biopsies has identified five mutations CYLD, including R758Q. As R758X mutational hotspot it been reported familial trichoepithelioma type 1, Brooke-Spiegler syndrome cylindromatosis. Thus, we attempted...
Abstract Background: NF-κB is an important signaling pathway for regulating multiple cascades involved in cancer development such as inflammation, immune response, cell survival, and proliferation. Constitutive activation of the plays a key role NPC. Our previous whole-exome sequencing (WES) study NPC biopsies has identified five mutations CYLD, including R758Q. As R758X mutational hotspot it been reported familial trichoepithelioma type 1, Brooke-Spiegler syndrome cylindromatosis. Thus, we...