A5009606299- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Neuroendocrine Tumor Research Advances
- Neuropeptides and Animal Physiology
- Cancer Genomics and Diagnostics
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Neurofibromatosis and Schwannoma Cases
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Signaling Pathways in Disease
- Pancreatic and Hepatic Oncology Research
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Cellular transport and secretion
Tufts Medical Center
2016-2025
Tufts University
2013-2024
University Medical Center
2018
Boston University
2013-2015
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2013-2014
National Institutes of Health
2013-2014
Erasmus MC
2014
Technische Universität Dresden
2014
University Health Network
2014
Royal Brisbane and Women's Hospital
2014
A single cell clonal line which responds reversibly to nerve growth factor (NGF) has been established from a transplantable rat adrenal pheochromocytoma. This line, designated PC12, homogeneous and near-diploid chromosome number of 40. By 1 week's exposure NGF, PC12 cells cease multiply begin extend branching varicose processes similar those produced by sympathetic neurons in primary culture. several weeks the reach 500-1000 mum length. Removal NGF is followed degeneration within 24 hr...
Although growing evidence points to highly indolent behavior of encapsulated follicular variant papillary thyroid carcinoma (EFVPTC), most patients with EFVPTC are treated as having conventional cancer.To evaluate clinical outcomes, refine diagnostic criteria, and develop a nomenclature that appropriately reflects the biological characteristics EFVPTC.International, multidisciplinary, retrospective study nodules diagnosed EFVPTC, including 109 noninvasive observed for 10 26 years 101...
Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions. We show here a functional link between with VHL and those disruption of the encoding for succinate dehydrogenase (SDH) subunits B (SDHB) D (SDHD). A transcription profile reduced oxidoreductase is detected all three tumor types, together an angiogenesis/hypoxia typical dysfunction....
Abstract Context.—Advances in genetics and gene expression profiling have led to new ways of thinking about the pathobiology pheochromocytoma extra-adrenal paraganglioma. These developments are concurrent with publication dissemination 2004 World Health Organization bluebook on pathology endocrine tumors. Objective.—To summarize information required by pathologists for effective participation patient management research. Data Sources.—Literature review primary material from Tufts Medical...
Brain (CATH.a) and adrenal (PATH.1 PATH.2) cell lines have been established that synthesize abundant dopamine norepinephrine express the appropriate catecholaminergic biosynthetic enzymes, tyrosine hydroxylase (TH) beta-hydroxylase. The were derived from TH-positive tumors in transgenic mice carrying SV40 T antigen oncogene under transcriptional control of 773 base pairs 5' flanking sequences rat TH gene. Although continue to antigen, they exhibit neuronal properties such as neurofilaments...
1. Adult human and gerbil adrenal medullary cells were maintained in dissociated cell culture studied by micro‐electrode penetration. 2. In the best recordings, chromaffin transmembrane potentials exceeded ‐50mV. 3. Chromaffin capable of generating all‐or‐nothing over‐shooting action potentials, similar to those generated sympathetic neurones. 4. The blocked tetrodotoxin (TTX, 10(‐6)g/ml.) but not removal Ca or CoCl2 (10 mM). We conclude that are probably a Na mechanism. 5. depolarized...
The occurrence of ≥ two distinct types tumors, one them paraganglioma (PGL), is unusual in an individual patient, except hereditary cancer syndromes.Four unrelated patients were investigated, with thorough clinical evaluation. Plasma and tissue catecholamines metanephrines measured by high-performance liquid chromatography. Anatomic functional imaging performed for tumor visualization. Germline DNA analyzed hypoxia-inducible factor 2 alpha (HIF2A) mutations. prolyl hydroxylation stability...
Glucocorticoids, cholera toxin, and high plating density all increase the activity of tyrosine 3-monooxygenase (TH) in cultured PC12 pheochromocytoma cells. Glucocorticoids enzyme cells treated with toxin grown at density. also content stored catecholamines In under routine conditions, glucocorticoids primarily stores dopamine. The addition ascorbate to culture medium increases storage norepinephrine both steroid-treated untreated Incubation media containing 56 nM K+ causes release same...
The body's homeostasis depends on the co-ordinated activity of nervous system and endocrine system. Although physiologic co-operation these two systems has long been recognized, neurons cells are generally regarded as developmentally functionally distinct. Neurons thought to be ectodermal origin function mostly elongated conducting structures that directly control behavior other by transmission electrical impulses localized release transmitter substances. Endocrine nonectodermal indirectly,...