A5003084338- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Sexual function and dysfunction studies
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Clinical Reasoning and Diagnostic Skills
- Adipose Tissue and Metabolism
- Medicine, History, and Philosophy
- Cardiovascular Syncope and Autonomic Disorders
- Cancer Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Renal function and acid-base balance
- Neuroblastoma Research and Treatments
- Sepsis Diagnosis and Treatment
- Dermatological diseases and infestations
- Metastasis and carcinoma case studies
- Sexuality, Behavior, and Technology
- Musculoskeletal synovial abnormalities and treatments
- Ovarian cancer diagnosis and treatment
- Sexual Differentiation and Disorders
- Neuroendocrine Tumor Research Advances
- Hormonal and reproductive studies
Noordwest Ziekenhuisgroep
2024
Radboud University Nijmegen
2012-2022
Radboud University Medical Center
2012-2022
University Medical Center
2019-2021
Geneeskundige en Gezondheidsdienst
2018
Malignant pheochromocytoma and paraganglioma (MPP) are characterized by prognostic heterogeneity. Our objective was to look for parameters of overall survival (OS) in MPP patients. Retrospective multicenter study a neck-thoraco-abdomino-pelvic CT or MRI at the time malignancy diagnosis European centers between 1998 2010. One hundred sixty-nine patients from 18 were included. Main characteristics with were: primary 53% patients; tumor- hormone-related symptoms 57% 58% cases; positive plasma...
Pheochromocytomas and paragangliomas (PPGLs) can be localized by <sup>18</sup>F-FDG PET. The uptake is particularly high in tumors with an underlying succinate dehydrogenase (<i>SDH</i>) mutation. SDHx-related PPGLs are characterized compromised oxidative phosphorylation a pseudohypoxic response, which mediates increase aerobic glycolysis, also known as the Warburg effect. aim of this study was to explore hypothesis that increased <i>SDHx</i>-related reflective glycolytic activity correlated...
Germline mutations in succinate dehydrogenase B ( SDHB ) predispose to hereditary paraganglioma (PGL) syndrome type 4. The risk of developing PGL or pheochromocytoma PHEO mutation carriers is subject recent debate. In the present nationwide cohort study identified by clinical genetics centers Netherlands, we have calculated penetrance associated tumors using a novel maximum likelihood estimator. This estimator addresses ascertainment bias and missing data on pedigree size structure. A total...
Objective Succinate dehydrogenase B subunit ( SDHB ) gene germline mutations predispose to pheochromocytomas, sympathetic paragangliomas, head and neck paragangliomas non-paraganglionic tumors (e.g. renal cell carcinoma, gastrointestinal stromal tumor pituitary neoplasia). The aim of this study was determine phenotypical characteristics a large Dutch cohort mutation carriers assess differences in clinical phenotypes related specific mutations. Design Retrospective descriptive study. Methods...
Based on germline and somatic mutation profiles, pheochromocytomas paragangliomas (PPGLs) can be classified into different clusters. We investigated the use of [18F]FDG-PET/CT radiomics, SUVmax biochemical profile for identification genetic clusters PPGLs.In this single-centre cohort, 40 PPGLs (13 cluster 1, 18 2, 9 sporadic) were delineated using a 41% adaptive threshold SUVpeak ([18F]FDG-PET) manually (low-dose CT; ldCT). Using PyRadiomics, 211 radiomic features extracted. Stratified...
Patients with pheochromocytomas and paragangliomas (PGLs) may have brown adipose tissue (BAT) activation induced by catecholamine excess. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed (CT) can be used for the localization of both PGLs BAT. It is unknown whether BAT specifically affected altered cellular energy metabolism in patients SDHx- VHL-related PGLs. The objective study was to determine endocrine paracrine effects excess on as detected 18F-FDG PET/CT,...
Localization of phaeochromocytomas and paragangliomas (PPGLs) should involve functional imaging as anatomical modalities can either fail to locate the tumour or be suboptimal due an abnormality previous surgery. Functional is particularly useful fully delineate extent disease using whole-body scan evaluation multifocality, metastatic recurrent disease. An increasing number radiolabeled tracers have become available for visualization during past decade. (123) I-meta-iodobenzylguanidine...
Static single–time-frame <sup>18</sup>F-FDG PET/CT is useful for the localization and functional characterization of pheochromocytomas paragangliomas (PPGLs). uptake varies between PPGLs with different genotypes, highest SUVs are observed in cases succinate dehydrogenase (<i>SDH</i>) mutations, possibly related to enhanced aerobic glycolysis tumor cells. The exact determinants accumulation unknown. We performed dynamic scanning assess whether vivo pharmacokinetics has added value over static...
<sup>123</sup>I-metaiodobenzylguanidine (<sup>123</sup>I-MIBG) scintigraphy plays an important role in the diagnostic evaluation of patients with pheochromocytoma and paraganglioma (PPGL). <sup>123</sup>I-MIBG targets cell membrane vesicular catecholamine transporters chromaffin cells facilitates localization primary tumor metastatic lesions. Its specificity for diagnosis adrenomedullary tumors can be jeopardized by physiologic uptake normal adrenal medulla. The aim this study was to...
Cross-sectional imaging with CT or MRI is regarded as a first-choice modality for tumor localization in patients pheochromocytoma and paraganglioma (PPGL). 123I-labeled metaiodobenzylguanidine (123I-MIBG) widely used functional but the added diagnostic value controversial.To establish virtual impact of adding 123I-MIBG scintigraphy to on diagnosis treatment PPGL.International multicenter retrospective study.None.Two hundred thirty-six unilateral adrenal, 18 bilateral 48 unifocal...
Germline mutations in succinate dehydrogenase subunit B and D (SDHB SDHD) are predisposed to hereditary paraganglioma (PGL) pheochromocytoma (PHEO). The phenotype of pathogenic variants varies according the causative gene. In this retrospective study, we estimate mortality a nationwide cohort SDHB variant carriers that large SDHD compare it matched general Dutch population. A total 192 232 were included study. Standard Mortality Ratio (SMR) for mutation was 1.89, increasing 2.88 affected by...
Background: Central necrosis can be detected on [18F]FDG PET/CT as a region with little to no tracer uptake. Currently, there is consensus regarding the inclusion of regions central during volume interest (VOI) delineation for radiomic analysis. The aim this study was assess how affects analysis in PET. Methods: Forty-three patients, either non-small cell lung carcinomas (NSCLC, n = 12) or pheochromocytomas paragangliomas (PPGL, 31), were included retrospectively. VOIs delineated and without...
Germline mutations in the succinate dehydrogenase B (SDHB) gene predispose to hereditary paraganglioma (PGL) syndrome type 4. The aim of this study was evaluate clinical characteristics and outcome treatment strategies for patients with head neck (HNPGL) carrying SDHB germline mutations.This a retrospective evaluation HNPGL Netherlands.In Dutch nationwide cohort mutation carriers, 54 total 62 HNPGLs were identified. Forty-one (76 per cent) visited outpatient clinic because associated...
Aims For decades, lymph node metastases (LNM) were considered to be stepping stones for distant metastasis (DM) in submucosal invasive colorectal cancers (T1 CRCs). Despite completion surgery, DM still developed 2-4% of T1 CRCs, suggesting a direct route metastases. Extensive research has been performed identify risk factors predict LNM. However, data on the relationship between these factors, and survival are very limited. The aim this study was investigate how affects CRC specific (CSS).
Pheochromocytoma and paraganglioma are catecholamine-producing tumors that associated with substantial serious morbidity mortality. A carefully taken medical history early consideration of such key for diagnosis treatment. The biochemical should include measurements metanephrines in either plasma or urine. In addition to anatomical imaging, sensitive functional imaging modalities offer extra benefit most patients locating the tumor eventual metastases. at least 30% all a...