A5074729988- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Sexual Differentiation and Disorders
- Electrolyte and hormonal disorders
- Hormonal and reproductive studies
- Bone health and treatments
- Glioma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Ion Transport and Channel Regulation
- Stress Responses and Cortisol
- Neuroendocrine Tumor Research Advances
- Estrogen and related hormone effects
- Health and Medical Studies
- Parathyroid Disorders and Treatments
- Meningioma and schwannoma management
- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Chronic Myeloid Leukemia Treatments
- Nuclear Structure and Function
- Diabetes and associated disorders
Charité - Universitätsmedizin Berlin
2014-2025
Humboldt-Universität zu Berlin
2017-2025
Freie Universität Berlin
2017-2025
National Center on Birth Defects and Developmental Disabilities
2010
Cross-sectional imaging regularly results in incidental discovery of adrenal tumours, requiring exclusion adrenocortical carcinoma (ACC). However, differentiation is hampered by poor specificity characteristics. We aimed to validate a urine steroid metabolomics approach, using profiling as the diagnostic basis for ACC.
Abstract We report on a 25‐year‐old woman with pronounced generalized lipodystrophy and progeroid aspect since birth, who also had Marfan syndrome (MFS; fulfilling the Ghent criteria) mild skeletal features, dilated aortic bulb, dural ectasia, bilateral subluxation of lens, severe myopia in addition to lipodystrophy. She lacked insulin resistance, hypertriglyceridemia, hepatic steatosis, diabetes. Mutation analysis gene encoding fibrillin 1 (FBN1) revealed novel de novo heterozygous...
Toll-like receptor-4 (TLR4) has been implicated in the pathogenesis of different renal diseases rodent models. However, human kidney disease, TLR4 expression and regulation is not well understood. We hypothesized that plays a role chronic disease (CKD) associated with proteinuria, function, histological diagnosis, inflammatory mediators.We quantified mRNA as macrophage chemoattractant protein-1 (MCP-1), transforming growth factor-β₁ (TGF-β₁) interleukin-6 (IL-6) biopsies from 70 patients...
Abstract Context Appropriate management of adrenal insufficiency (AI) in pregnancy can be challenging due to the rarity disease and lack evidence-based recommendations guide glucocorticoid mineralocorticoid dosage adjustment. Objective Multicenter survey on current clinical approaches managing AI during pregnancy. Design Retrospective anonymized data collection from 19 international centers 2013 2019. Setting Patients 128 pregnancies 113 women with different causes AI: Addison (44%),...
Mitotane is the only approved drug for advanced adrenocortical carcinoma (ACC) and no biomarkers are available to predict attainment of therapeutic plasma concentrations clinical response. Aim study was evaluate suitability cytochrome P450(CYP)2W1 CYP2B6 single nucleotide polymorphisms (SNPs) as biomarkers. A multicenter cohort including 182 ACC patients (F/M = 121/61) treated with mitotane monotherapy after radical resection (group A, n 103) or in not completely resectable, recurrent...
Patients with adrenal insufficiency (AI) suffer from impaired quality of life and are at risk crisis (AC) despite established replacement therapy. Patient education is regarded an important measure for prevention AC improvement AI management. A standardized programme was elaborated patients chronic in Germany.Longitudinal, prospective, questionnaire-based, multi-centre study.During 2-h sessions, (n = 526) were provided basic knowledge on AI, equipped emergency cards sets trained...
Patients with primary adrenal insufficiency (PAI) or congenital hyperplasia (CAH) receive life-long glucocorticoid (GC) therapy. Daily GC doses are often above the physiological cortisol production rate and can cause long-term morbidities such as osteoporosis. No prospective trial has investigated effect of different therapies on bone mineral density (BMD) in those patients.To determine if patients hydrocortisone (HC) prednisolone show changes BMD after follow-up 5.5 years. To investigate is...
Shift work causes a disruption between the circadian system and external light-dark cycle, but also misalignment various levels of system. There is no information on patients with adrenal insufficiency (AI) who are working shifts. The objective study was to analyze hormone replacement therapy hydrocortisone (HC) adaptation scheme in AI Patients shifts (n=15) from two German endocrine centers received questionnaire regarding their scheme, dose adaptations, shifts, adaptations during...
Parathyroid carcinoma is a rare disease leading to severe hypercalcemia due hyperparathyroidism. Surgery the primary treatment option. A more progressive form of characterized by parathyrotoxicosis, and subsequent most common cause death. We report case presenting with parathyrotoxicosis from parathyroid treated for first time using monoclonal antibody denosumab as rescue therapy present long-term follow-up data. The 71-year-old patient presented metastatic carcinoma. Despite undergoing...
Nonalcoholic fatty liver disease represents the hepatic manifestation of metabolic syndrome. steatohepatitis (NASH) is progressive form injury. The pathophysiology that leads to NASH not well understood.We hypothesize an altered cortisol metabolism in may be a pathogenetic factor.75 patients (28 men, 47 women) underwent biopsy for elevation enzymes. Histological diagnosis identified normal eight, 20, grade 1 22, 2 nine, 3 three patients, and other forms hepatitis or cirrhosis 13 patients. We...
With the beginning of puberty blood pressure increases and is persistently higher in men than premenopausal women. Sex steroids are known to have complex effects on renal cardiovascular system involved regulation. The epithelial sodium channel (ENaC) modulates reabsorption kidney, but little about sex-specific regulation ENaC subunit expression. Regulation androgen receptor (AR) be tissue-specific age-dependent, not well studied kidney. We investigated sex subunits AR expression an vivo rat...
Background: Sex differences in clinical picture of ACTH-dependent Cushing's syndrome are controversial, except for the known higher prevalence females. We compared a broad range potential to enable more accurate understanding sex-specific syndrome. Methods: Cohort study including consecutive patients with from Leiden and Berlin diagnosed between 2000 2016. presentation, biochemical parameters, diagnostic tests, surgical outcome, comorbidities men women. Results: included 130 patients: 37...
Abstract Context An important clinical feature of Cushing’s syndrome (CS) is proximal muscle myopathy caused by glucocorticoid induced protein metabolism. However, interindividual differences cannot be explained solely the pure extent hypercortisolemia. Objective To evaluate effects receptor (GR) polymorphisms (BclI, N363S, ER22/23EK and A3669G), which influence peripheral sensitivity on muscular function in endogenous CS. Methods 205 patients with proven CS (128 central, 77 adrenal) from 3...
Abstract Background Patients with adrenal insufficiency (AI) require lifelong glucocorticoid (GC) replacement. AI patients need to adjust GC dosage in response stressful events and illness order prevent life‐threatening crisis (AC). Aim To evaluate self‐management of AI. Methods Four German centres, which are using patient's diary as part their routine clinical practice, instructed prospectively document any discomfort, intercurrent or well changes therapy on a daily basis. Diaries 80 (44...
Adrenal crisis, the most feared complication of adrenal insufficiency, is a potentially life-threatening state acute glucocorticoid deficiency. After successful surgery for Cushing's syndrome, many patients develop (transient) insufficiency. The incidence crisis in treated hypercortisolism unknown.Cohort study included consecutive with syndrome insufficiency after from Leiden and Berlin 2000 to 2015. We summarized compared without regarding potential risk factors its occurrence assessed...
Abstract Based on recent data, a total number of about 29 000 patients with adrenal insufficiency can be calculated for Germany, and 1500 fatalities due to crises have expected within the next decade. Management is still unsatisfactory. The objectives this study were establish consensus diagnostic criteria, prevention strategies, treatment recommendations crises. was conducted from January 2022 April 2023, using Delphi technique. Four rounds questionnaires sent 45 experts, selected by...
Sex-specific differences in blood pressure (BP) suggest an important modulating role of testosterone the kidney. However, little is known about interaction between androgens and mineralocorticoid aldosterone. Our objective was to determine effects gonadectomized male female rats on a low-salt diet, effect androgen receptor (AR) blockade by flutamide BP aldosterone levels.Normotensive Wistar were put diet. They treated for 16 days with or placebo. In addition, animals received AR antagonist...