Anthony Stell
A5009124608- Scientific Computing and Data Management
- Distributed and Parallel Computing Systems
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Access Control and Trust
- Traumatic Brain Injury and Neurovascular Disturbances
- Peer-to-Peer Network Technologies
- Pituitary Gland Disorders and Treatments
- Machine Learning in Healthcare
- Electronic Health Records Systems
- Healthcare Technology and Patient Monitoring
- Cancer, Hypoxia, and Metabolism
- Ethics in Clinical Research
- Distributed systems and fault tolerance
- Cloud Data Security Solutions
- Hemodynamic Monitoring and Therapy
- Diabetes Management and Research
- Cryptography and Data Security
- Advanced Data Storage Technologies
- Traumatic Brain Injury Research
- Semantic Web and Ontologies
- Neural Networks and Applications
- Biomedical Text Mining and Ontologies
- Diabetes and associated disorders
- Mobile Health and mHealth Applications
The University of Melbourne
2015-2025
Radboud University Nijmegen
2025
Radboud University Medical Center
2025
University of Glasgow
2006-2021
Queen Elizabeth University Hospital
2021
Azienda Ospedaliera di Padova
2021
University of Padua
2021
Walter de Gruyter (Germany)
2021
Université Paris Cité
2016
Universitätsklinikum Würzburg
2016
Recurrence of adrenocortical carcinoma (ACC) even after complete (R0) resection occurs frequently. The aim this study was to identify markers with prognostic value for patients in clinical setting. From the German ACC registry, 319 European Network Study Adrenal Tumors stage I–III were identified. As an independent validation cohort, 250 from three countries included. Clinical, histological, and immunohistochemical correlated recurrence-free (RFS) overall survival (OS). Although univariable...
Cross-sectional imaging regularly results in incidental discovery of adrenal tumours, requiring exclusion adrenocortical carcinoma (ACC). However, differentiation is hampered by poor specificity characteristics. We aimed to validate a urine steroid metabolomics approach, using profiling as the diagnostic basis for ACC.
Objective Hypertension and symptoms of catecholamine excess are features pheochromocytomas paragangliomas (PPGLs). This prospective observational cohort study assessed whether differences in presenting patients tested for PPGLs might assist establishing likelihood disease. Design methods Patients were because signs symptoms, an incidental mass on imaging or routine surveillance due to previous history hereditary risk. with ( n = 245) compared without 1820) identified follow-up. Differences...
Context Measurements of plasma methoxytyramine, the O-methylated dopamine metabolite, are useful for detecting rare dopamine-producing pheochromocytomas and paragangliomas (PPGLs) head neck (HNPGLs), but utility screening beyond that achieved using standard measurements normetanephrine metanephrine is unclear. Objective Evaluation additional methoxytyramine compared to diagnosis PPGLs HNPGLs. Design Comparative prospective study. Methods Comparison mass spectrometric-based in 1963 patients...
Arterial hypertension is a major cardiovascular risk factor. Identification of secondary in its various forms key to preventing and targeting treatment complications. Simplified diagnostic tests are urgently required distinguish primary address the current underdiagnosis latter.This study uses Machine Learning (ML) classify subtypes endocrine (EHT) large cohort hypertensive patients using multidimensional omics analysis plasma urine samples. We measured 409 multi-omics (MOmics) features...
OBJECTIVE Technology use in type 1 diabetes (T1D) is impacted by socioeconomic status (SES). This analysis explored relationships between SES, glycemic outcomes, and technology use. RESEARCH DESIGN AND METHODS A cross-sectional of HbA1c data from 2,822 Australian youth with T1D was undertaken. Residential postcodes were used to assign SES based on the Index Relative Socio-Economic Disadvantage (IRSD). Linear regression models evaluate associations among IRSD quintile, HbA1c, management...
Abstract Objectives Plasma free metanephrines are commonly used for diagnosis of pheochromocytoma and paraganglioma (PPGLs), but can also provide other information. This multicenter study prospectively examined whether tumor size, location, mutations could be predicted by these metabolites. Methods Predictions mutation type, based on measurements plasma normetanephrine, metanephrine, methoxytyramine were made without knowledge disease in 267 patients subsequently determined to have PPGLs....
Abstract Objective Hypertension is a major cardiovascular risk factor affecting about 1 in 3 adults. Although the majority of hypertension cases (∼90%) are classified as ‘primary hypertension’ (PHT), endocrine (EHT) accounts for ∼10% and caused by underlying conditions such primary aldosteronism (PA), Cushing's syndrome (CS), pheochromocytoma or paraganglioma (PPGL). EHT often misdiagnosed PHT leading to delays treatment condition, reduced quality life costly, ineffective, antihypertensive...
Abstract Objective Individual patients' data sharing requires interoperability, security, ethical, and legal compliance. The aim was to assess the landscape capacities between endocrine researchers. Design A standardized survey (SurveyMonkey®) with 67 questions sent European Network for Study of Adrenal Tumors centers. Methods Answers were counted as absolute numbers percentages. Comparisons inclusiveness target countries (ITC) non-ITC (defined by Cooperation in Science & Technology...
Hypertension increases complication risk in type 1 diabetes (T1D). We examined blood pressure (BP) adolescents and young adults with T1D from the Australasian Diabetes Data Network, a prospective clinical registry Australia New Zealand.This was longitudinal study of prospectively collected data.T1D (duration ≥ year) age 16-25 years at last visit (2011-2020). defined as (on 3 occasions) systolic BP and/or diastolic > 95th percentile for < 18 years, 130 80 mmHg years. Multivariable Generalised...
Background Medication-related interferences with measurements of catecholamines and their metabolites represent important causes false-positive results during diagnosis phaeochromocytomas paragangliomas (PPGLs). Such are less troublesome by liquid chromatography tandem mass-spectrometry (LC-MS/MS) than other methods, but can still present problems for some drugs. Levodopa, the precursor dopamine used in treatment Parkinson’s disease, represents one potentially interfering medication. Methods...
Grids allow for collaborative e-Research to be undertaken, often across institutional and national boundaries. Typically this is through the establishment of virtual organizations (VOs) where policies on access usage resources partner sites are defined subsequently enforced. For many VOs, these agreements have been lightweight erred side flexibility with minimal constraints kinds jobs a user allowed run or amount that can consumed. new domains such as e-Health, simply not tenable. Instead,...
Abstract Context Sexual dimorphism has direct consequences on the incidence and survival of cancer. Early accurate diagnosis is crucial to improve prognosis. Objective This work aimed characterized influence sex adrenal asymmetry emergence tumors. Methods We conducted a multicenter, observational study involving 8037 patients with tumors, including adrenocortical carcinoma (ACC), aldosterone-producing adenoma (APA), cortisol-secreting adenomas (CSAs), non-aldosterone-producing cortical...
The widespread use of grid technology and distributed compute power, with all its inherent benefits, will only be established if the that can guaranteed efficient secure. predominant method for currently enforcing security is through public key infrastructures (PKI) to support authentication access control lists (ACL) authorisation. These systems alone do not provide enough fine-grained over restriction user rights, necessary in a dynamic environment. This paper compares implementation...
Australia has a high prevalence of diabetes, with approximately 1.2 million Australians diagnosed the disease. In 2012, Australasian Diabetes Data Network (ADDN) was established funding from Juvenile Research Foundation (JDRF). ADDN is national diabetes registry which captures longitudinal information about patients type-1 (T1D). Currently, data are directly contributed 42 paediatric and 17 adult centres across New Zealand, i.e., where pre-existing in hospital systems not manually entered...
The ability to predict adverse hypotensive events, where a patient's arterial blood pressure drops abnormally low (and dangerous) levels, would be of major benefit the fields primary and secondary health care, especially traumatic brain injury domain. A wealth data exist in care systems providing information on indicators patients hospitals (blood pressure, temperature, heart rate, etc.). It is believed that if enough these could drawn together analysed systematic way, then system built will...
Background Pheochromocytomas and paragangliomas (PPGLs) are rare but potentially harmful tumors that can vary in their clinical presentation. Tumors may be found due to signs symptoms, as part of a hereditary syndrome or following an imaging procedure. Objective To investigate potential differences presentation between PPGLs discovered by (iPPGLs), symptomatic cases (sPPGLs) those diagnosed during follow-up because earlier disease/known mutations (fPPGL). Design Prospective study protocol,...
Abstract Context Sampling of blood in the supine position for diagnosis pheochromocytoma and paraganglioma (PPGL) results lower rates false positives plasma normetanephrine than seated sampling. It is unclear how inpatient vs outpatient testing other preanalytical factors impact positives. Objective We aimed to identify precautions minimize false-positive metanephrines. Methods Impacts different sampling conditions on metanephrines were evaluated, including testing, semi- fully recumbent...
The BRIDGES project was funded by the UK Department of Trade and Industry (DTI) to address needs cardiovascular research scientists investigating genetic causes hypertension as part Wellcome Trust (#4.34M) functional genomics (CFG) project. Security at heart an advanced data compute grid infrastructure incorporating latest authorisation technologies developed delivered scientists. We outline these infrastructures describe perceived security requirements start including classifications how...