A5029466731- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adipose Tissue and Metabolism
- Thyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- Obesity, Physical Activity, Diet
- Sleep and related disorders
- Growth Hormone and Insulin-like Growth Factors
- Sleep and Work-Related Fatigue
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Disease and Adiposity
- RNA Research and Splicing
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Birth, Development, and Health
- Hormonal and reproductive studies
- Vitamin D Research Studies
Zhongda Hospital Southeast University
2024-2025
Lanzhou University
2024-2025
Sun Yat-sen University
2015-2024
Fudan University
2015-2024
Zhongshan Hospital
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Anhui University
2024
Shenzhen Institute of Information Technology
2024
Harbin Institute of Technology
2024
Shanghai International Studies University
2023-2024
Polycystic ovary syndrome (PCOS), a prevalent reproductive disorder in women of age, features androgen excess, ovulatory dysfunction, and polycystic ovaries. Despite its high prevalence, specific pharmacologic intervention for PCOS is challenging. In this study, we identified artemisinins as anti-PCOS agents. Our finding demonstrated the efficacy artemisinin derivatives alleviating symptoms both rodent models human patients, curbing hyperandrogenemia through suppression ovarian synthesis....
Abstract Significant concerns have been raised owing to the rapid global spread of infection and disease caused by mosquito-borne Zika virus (ZIKV). Recent studies suggest that ZIKV can also be transmitted sexually, further increasing exposure risk for this virus. Associated with is a dramatic increase in cases microcephaly additional congenital abnormalities infants ZIKV-infected mothers, as well rise occurrence Guillain Barre’ syndrome infected adults. Importantly, there are no licensed...
The metabolic regulation of cell death is sophisticated. A growing body evidence suggests the existence multiple checkpoints that dictate fate in response to fluctuations. However, whether microRNAs (miRNAs) are able respond stress, reset threshold death, and attempt reestablish homeostasis largely unknown. Here, we show miR-378/378* KO mice cannot maintain normal muscle weight have poor running performance, which accompanied by impaired autophagy, accumulation abnormal mitochondria,...
Branched-chain amino acids (BCAAs), essential nutrients including leucine, isoleucine, and valine, serve as a resource for energy production the regulator of important nutrient metabolic signals. Recent studies have suggested that dysfunction BCAA catabolism is associated with risk cardiovascular disease. Platelets play an role in disease, but functions platelets remain unknown.The activity human from healthy subjects before after ingestion BCAAs was measured. Protein phosphatase 2Cm...
Although obesity is associated with low-grade inflammation and metabolic disorders, clinical studies suggested some obese people were metabolically healthy smaller adipocyte size compared abnormal (MAO). This indicated may be an important predictor underlay the distinction between MAO obese. As recent study has shown that adipocytes expressed class II major histocompatibility complex (MHCII), which functioned as APCs during obesity. However, relationship hypertrophy MHCII expression was not...
Abstract As cancer is increasingly considered a metabolic disorder, it postulated that serum metabolite profiling can be viable approach for detecting the presence of cancer. By multiplexing mass spectrometry fingerprints from two independent nanostructured matrixes through machine learning highly sensitive detection and high throughput analysis, we report laser desorption/ionization (LDI) spectrometry-based liquid biopsy pan-cancer screening classification. The M ultiplexed N anomaterial- A...
Abstract Thyroid hormones (TH) regulate systemic glucose metabolism through incompletely understood mechanisms. Here, we show that improved in hypothyroid mice after T3 treatment is accompanied with increased glucagon-like peptide-1 (GLP-1) production and insulin secretion, while co-treatment a GLP-1 receptor antagonist attenuates the effects of on levels. By using lacking hepatic TH β (TRβ) liver-specific TRβ-selective agonist, demonstrate TRβ-mediated signalling required for both...
It is known that thyroid hormone (TH) a major determinant of muscle fiber composition, but the molecular mechanism by which it does so remains unclear. Here, we demonstrated miR-133a1 direct target gene TH in muscle. Intriguingly, miR-133a, enriched fast-twitch muscle, regulates slow-to-fast type conversion targeting TEA domain family member 1 (TEAD1), key regulator slow expression. Inhibition miR-133a vivo abrogated action on conversion. Moreover, TEAD1 overexpression antagonized effect as...
Abstract The study aimed to estimate prevalence and influencing factors of overweight, general obesity, abdominal obesity in rural areas China. A total 39034 participants aged 18 79 years were enrolled from the Henan Rural Cohort Study for cross-sectional study. age-standardized 34.97%, 16.82%, 43.71% Chinese adults, respectively. Gender differences were: 36.04%, 18.98%, 35.37% men, 34.55%, 15.42%, 49.13% women, subgroup analysis showed rates existed considerable disparities, but universally...
Abstract Context Pheochromocytomas and paragangliomas (PPGLs) are characterized by distinct genotype-phenotype relationships according to studies largely restricted Caucasian populations. Objective To assess for possible differences in genetic landscapes of PPGLs Chinese versus European Design Cross-sectional study. Setting 2 tertiary-care centers China 9 Europe. Participants Patients with pathologically confirmed diagnosis PPGL, including 719 919 Europeans. Main Outcome Measures...
Abstract The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is not fully understood. Here, we show that long-term treatment T3, the active form TH, increases thermogenic capacity in interscapular BAT male mice through hyperplasia by promoting TH receptor α-mediated adipocyte progenitor cell proliferation. Our single-cell analysis reveals heterogeneous nature and hierarchical trajectory within cells BAT. Further analyses suggest T3 facilitates state...
ABSTRACT Previous studies have indicated an association of fat mass and obesity-associated (FTO) with nonalcoholic fatty liver disease (NAFLD), the most common chronic worldwide. This study aimed to decipher complex role FTO in hepatic lipid metabolism. We found that a decrease N6-methyladenosine (m6A) RNA methylation mice fed high-fat diet (HFD) was accompanied by increase expression. Overexpression promoted triglyceride accumulation upregulating expression lipogenic genes. Mechanistical...
Thyroid hormone (TH) has a profound effect on energy metabolism and systemic homeostasis. Adipose tissues are crucial for maintaining whole-body homeostasis; however, whether TH regulates metabolic homeostasis through its action adipose is unclear. Here, we demonstrate that administration of triiodothyronine (T3), the active form TH, affects both inguinal white tissue (iWAT) metabolism. Taking advantage mouse model lacking adipocyte receptor (TR) α or TRβ, show TRβ major TR isoform mediates...
Understanding the fiber-type specification and metabolic switch in skeletal muscle provides insights into energy metabolism physiology diseases. Here, we show that miR-182 is highly expressed fast-twitch negatively correlates with blood glucose level. knockout mice display loss, fast-to-slow switching, impaired metabolism. Mechanistic studies reveal modulates utilization by targeting FoxO1 PDK4, which control fuel selection via pyruvate dehydrogenase complex (PDHC). Short-term high-fat diet...
The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption the beneficial microbiome compels urgent investigation bacteria-specific approaches such as antibody-based strategies. Among these, DNA-delivered monoclonal antibodies (DMAbs), produced by muscle cells in vivo, potentially allow prevention or treatment bacterial infections circumventing some hurdles protein IgG delivery. Here, we optimize consisting two potent human clones, including a non-natural bispecific...
Background: Epidemiological studies about cardiovascular disease in rural areas of developing countries are rare. This study aimed to estimate the prevalence and influencing factors coronary heart (CHD) stroke Chinese population. Methods: 39,259 subjects (15,490 males) aged 18-79 years were enrolled from Henan Rural Cohort Study. Age-standardized was calculated according 6th Population Census. Associations between risk diseases estimated by odds ratios 95% confidence intervals with...
Abstract Objective Paragangliomas of the urinary bladder (UBPGLs) are rare neuroendocrine tumours and pose a diagnostic surgical challenge. It remains unclear what factors contribute to timely presurgical diagnosis. The purpose this study is identify contributing missing diagnosis UBPGLs before surgery. Design, Patients Measurements A total 73 patients from 11 centres in China, 51 6 Europe 1 center United States were included. Clinical, genetic data collected compared diagnosed versus after...
Type 2 diabetes mellitus (T2DM) has become one of the most serious and long-term threats to human health. However, molecular mechanism that links obesity insulin resistance remains largely unknown. Here, we show F-box WD repeat domain-containing 7 (FBXW7), an E3 ubiquitin protein ligase, is markedly downregulated in liver two obese mouse models subjects. We further identify a functional low-frequency FBXW7 coding variant (p.Ala204Thr) Chinese population, which associated with elevated blood...
Thyroid hormones (THs) are potent modulating liver lipid homeostasis. The perturbation of homeostasis is a hallmark non-alcoholic fatty disease (NAFLD), very common disorder. It was reported that NAFLD patients were associated with higher incidence hypothyroidism. However, whether abnormal thyroid function contributes to the pathogenesis remains unclear.We used in vivo models investigate influence hypothyroidism and TH on hepatic We did not observe triglyceride accumulation hypothyroid mice,...
Abstract Background This study aims to investigate the prevalence and associated factors of major depressive disorder (MDD) generalized anxiety (GAD) by gender in Chinese rural adults. Methods A total 29,993 participants aged from 18 79 years Henan Rural Cohort Study were included this study. The Patient Health Questionnaire-2 (PHQ-2) Generalized Anxiety Disorder-2 (GAD-2) used assess MDD GAD through a face-to-face interview. Multivariate logistic regression model was conducted analyze for...