A5061706594- Pancreatic function and diabetes
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Lipid metabolism and disorders
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Diabetes Management and Research
- Regulation of Appetite and Obesity
- Epigenetics and DNA Methylation
- Bariatric Surgery and Outcomes
- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
Shanghai Jiao Tong University
2016-2025
Shanghai Sixth People's Hospital
2016-2025
Xian Central Hospital
2017-2025
Southern Medical University
2017-2025
China Medical University
2025
First Hospital of China Medical University
2025
Shanghai Clinical Research Center
2010-2025
Jinzhou Medical University
2025
Shanghai University of Traditional Chinese Medicine
2025
Minzu University of China
2025
Abstract Recent studies revealed strong evidence that branched-chain and aromatic amino acids (BCAAs AAAs) are closely associated with the risk of developing type 2 diabetes in several Western countries. The aim this study was to evaluate potential role BCAAs AAAs predicting development Chinese populations. serum levels valine, leucine, isoleucine, tyrosine, phenylalanine were measured a longitudinal cross sectional total 429 participants at different stages development, using an...
Nonalcoholic fatty liver disease (NAFLD) is characterized by accumulation of excessive triglycerides (TGs) in hepatocytes. Obesity a major risk factor for developing liver, although the intracellular molecular basis remains largely unclear. N6 -methyladenosine (m6 A) RNA methylation most common internal modification eukaryotic mRNA. In present study, m6 A sequencing and sequencing, we found that both enrichment mRNA expression lipogenic genes were significantly increased...
Abstract Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, gut microbiome associated with energy harvest alters dramatically in response nutrient deprivation. Here, we reported that CR high-fat diet (HFD) both remodeled microbiota similar microbial composition, Parabacteroides distasonis was most significantly decreased or HFD. altered reprogramed metabolism, resulting a distinct serum...
Hyocholic acid (HCA) is a major bile (BA) species in the BA pool of pigs, known for its exceptional resistance to spontaneous development diabetic phenotypes. HCA and derivatives are also present human blood urine. We investigate whether profiles can predict metabolic disorders. find first cohort (n = 1107) that both obesity diabetes associated with lower serum concentrations species. A separate study 91) validates this finding further reveals individuals pre-diabetes levels feces. Serum...
Abstract Background Age‐associated sarcopenia is characterized of progressed loss skeletal muscle power, mass, and function, which affects human physical activity life quality. Besides, accompanied with sarcopenia, aged population also faces a series metabolic dysfunctions. Irisin, the cleaved form fibronectin type III domain‐containing protein 5 (FNDC5), myokine induced by exercise has been shown to exert multiple beneficial effects on health. The goal study investigate alterations...
Substantial progress has been made in identification of type 2 diabetes (T2D) risk loci the past few years, but our understanding genetic basis T2D ethnically diverse populations remains limited. We performed a genome-wide association study and replication Chinese Hans comprising 8,569 case subjects 8,923 control total, from which 10 single nucleotide polymorphisms were selected for further follow-up de novo sample 3,410 3,412 an silico 6,952 11,865 subjects. Besides confirming seven...
Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt analyze independent and joint effect of variants from these on clinical phenotypes related glucose metabolism.Twenty-one single nucleotide polymorphisms (SNPs) fourteen were successfully genotyped 1,849 subjects with 1,785 normal regulation. We analyzed allele genotype distribution between cases controls SNPs as well effects risk. The associations examined by...
Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a large genetic component to be clarified. To explore unidentified T2D, we performed genome-wide association study (GWAS) of 6 209 637 single-nucleotide polymorphisms (SNPs), which were directly genotyped or imputed using East Asian references from the 1000 Genomes Project (June 2011 release) in 5976 Japanese patients with T2D and 20 829 nondiabetic individuals. Nineteen unreported selected taken...
Obesity is not a homogeneous condition across individuals since about 25-40% of obese can maintain healthy status with no apparent signs metabolic complications. The simple anthropometric measure body mass index does always reflect the biological effects excessive fat on health, thus additional molecular characterizations phenotypes are needed to assess risk developing subsequent conditions at an individual level.To better understand associations free fatty acids (FFAs) obesity, we applied...
<b>Objectives</b> To evaluate haemoglobin A1c (HbA<sub>1c</sub>) in diagnosing diabetes and identify the optimal HbA<sub>1c</sub> threshold to be used Chinese adults. <b>Design</b> Multistage stratified cross sectional epidemiological survey. <b>Setting</b> Shanghai, China, 2007-8. <b>Participants</b> 4886 adults over 20 years of age with no history diabetes. <b>Main outcome measures</b> Performance at increasing thresholds for <b>Results</b> The area under receiver operating characteristics...
Recently, 5 amino acids were identified and verified as important metabolites highly associated with type 2 diabetes (T2D) development. This report aims to assess the association of tryptophan development T2D evaluate its performance existing acid markers. A total 213 participants selected from a ten-year longitudinal Shanghai Diabetes Study (SHDS) examined in two ways: 1) 51 subjects who developed 162 individuals remained metabolically healthy 10 years; 2) same future 23 strictly matched...