A5020433600- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Cancer survivorship and care
- Colorectal Cancer Screening and Detection
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Cancer-related cognitive impairment studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Nutrition, Genetics, and Disease
- RNA and protein synthesis mechanisms
- Phytoestrogen effects and research
- Multiple and Secondary Primary Cancers
- Childhood Cancer Survivors' Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- Family Support in Illness
- Endometrial and Cervical Cancer Treatments
AstraZeneca (United States)
2023-2025
East China Normal University
2019-2024
Zhongshan Ophthalmic Center, Sun Yat-sen University
2024
Sheng Jing Hospital
2024
Ningbo University
2023
Beijing National Laboratory for Molecular Sciences
2023
Second Xiangya Hospital of Central South University
2023
Central South University
2023
Tianjin Medical University Cancer Institute and Hospital
2023
Linyi University
2023
Nonalcoholic fatty liver disease (NAFLD) is characterized by accumulation of excessive triglycerides (TGs) in hepatocytes. Obesity a major risk factor for developing liver, although the intracellular molecular basis remains largely unclear. N6 -methyladenosine (m6 A) RNA methylation most common internal modification eukaryotic mRNA. In present study, m6 A sequencing and sequencing, we found that both enrichment mRNA expression lipogenic genes were significantly increased...
Abstract Neoadjuvant chemoimmunotherapy improves pathologic complete response rate and event-free survival in patients with resectable non–small cell lung cancer (NSCLC) versus chemotherapy alone. NeoCOAST was the first randomized, multidrug platform trial to examine novel neoadjuvant immuno-oncology combinations for NSCLC, using major (MPR) as primary endpoint. Eighty-three received a single cycle of treatment: 26 durvalumab (anti–PD-L1) monotherapy, 21 plus oleclumab (anti-CD73), 20...
To examine the association of quality life (QOL) after diagnosis breast cancer with mortality and recurrence.From 2002 to 2004, a total 2,230 survivors completed General Quality Life Inventory-74 6 months as part Shanghai Breast Cancer Survivor Study. Also collected at baseline was information on demographic clinical characteristics. At 36 postdiagnosis, 1,845 these women were re-evaluated for QOL. Outcomes ascertained by in-person interview record linkage vital statistics registry. The QOL...
It has been suggested that exercise following breast cancer diagnosis is inversely associated with mortality. However, controversy exists regarding the causality of such associations. We evaluated associations after total mortality and recurrence/disease-specific mortality, accounting for conditions restrict participation. The analysis included 4,826 women stage I to III identified 6 months through population-based Shanghai Cancer Registry recruited into study between 2002 2006. Exercise was...
Large social networks have been associated with better overall survival, though not consistently breast cancer (BC)-specific outcomes. This study evaluated associations of postdiagnosis and BC outcomes in a large cohort.Women from the After Breast Cancer Pooling Project (n = 9267) provided data on within approximately 2 years their diagnosis. A network index was derived information about presence spouse/partner, religious ties, community friendship numbers living first-degree relatives. Cox...
Etiologic differences between subtypes of breast cancer defined by estrogen receptor (ER) and progesterone (PR) status are not well understood. The authors evaluated associations hormone-related factors with in a population-based case-control study involving 1,409 ER-positive (ER+)/PR-positive (PR+) cases, 712 ER-negative (ER-)/PR-negative (PR-) 301 ER+/PR- 254 ER-/PR+ 3,474 controls aged 20-70 years Shanghai, China (phase I, 1996-1998; phase II, 2002-2005). Polytomous logistic regression...
Pancreatic cancer is a devastating disease with dismal prognosis. Large population-based evidence on its survival rate and influence factors lacking in China.This study aimed to depict the demographic factors, tumor characteristics, incidence of pancreatic cases urban China.The characteristics were collected for all identified during 2004 2009 from Shanghai Cancer Registry. The time was ascertained through linkage Registry Vital Statistics deadline death certificates end December 2012....
Previous studies have suggested that Lycium barbarum (L. barbarum) has a radioprotective function, although more in-depth investigation is still required. We investigated the efficacy of extract fruits L. (LBE) and its mechanisms. Mice were exposed to 8.5 Gy, 5.5 or 6.0 Gy total body irradiation (TBI), survival rate, lymphocyte percentage, amount cytokines, viability irradiated cells, as well gut microbiome fecal metabolomics studied. LBE enhanced mice γ-ray TBI X-ray TBI. After TBI,...
Background and objective Metabolic syndrome (MetS) is an important risk factor for cardiovascular complications kidney damage. Obesity- lipid-related indices are closely related to MetS, different have predictive abilities MetS. This study aimed evaluate the value of eight obesity- indicators, namely, body mass index (BMI), lipid accumulation product (LAP), roundness (BRI), Chinese visceral adiposity (CVAI), (BAI), abdominal volume (AVI), triglyceride glucose (TYG), (VAI), Methods A total...
The effects of diet on breast cancer are controversial and whether the vary with hormone receptor status has not been well investigated. This study evaluated associations dietary factors risk for overall by tumors among Chinese women. Shanghai Breast Cancer Study, a large, population-based, case-control study, enrolled 3,443 cases 3,474 controls in 1996–1998 (phase I) 2002–2005 II); 2676 had estrogen (ER) progesterone (PR) data. Dietary intake was assessed using validated, quantitative, food...
The incidence and mortality rate of colorectal cancer (CRC) have increased dramatically over the past 3 decades in China due to changes lifestyle factors. Early detection treatment guidelines for asymptomatic cases shown improve CRC control developed countries. In response these challenges, Shanghai Municipal Government launched a community-based screening program 2012.Free initial screening, inclusive immunochemical fecal occult blood risk assessment (questionnaire), was provided by...
Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias incidence evaluation. Most population-based cancer registries grouped of minor salivary glands with oral instead as a whole, because international disease coding. Thus, has not well assessed. The aim study evaluate both major Shanghai during years 2003-2012, analyse site histological...
PURPOSE To examine the association of lifestyle factors and supplement use with depression among breast cancer survivors. PATIENTS AND METHODS In a population-based cohort study conducted between April 2002 December 2006 in Shanghai, China, total 1,399 women who were diagnosed stage 0 to III completed 6-month 18-month postdiagnosis, in-person interviews. Information on sociodemographic, clinical, collected through interviews review medical charts at approximately 6 months postdiagnosis. A...
The authors evaluated the effect of regular exercise during first 36 months after cancer diagnosis on quality life (QOL) in a population-based cohort study 1,829 Chinese women diagnosed with breast cancer. were identified between 2002 and 2004 invited to participate about 6 diagnosis. Exercise was assessed approximately 6, 18, diagnosis, metabolic equivalent task (MET) score hours per week derived. A cumulative, weighted exercise-MET created for 36-month postdiagnosis period. QOL at...
We assessed weight change from diagnosis to approximately 18 mo after cancer and evaluated its correlates in a large, population-based, cohort study of women diagnosed with stage 0–IV breast cancer. A total 4,561 cases information 1 yr prior diagnosis, at the 18-mo postdiagnosis interview were included study. Multinomial logistic regression models conducted examine association sociodemographic, clinical, lifestyle factors. The mean was gain 1.7 kg (median: 2.0). Overall, 61% gained weight,...
Abstract Background Self-reported information is an important tool for collecting clinical epidemiologic studies and in settings where electronic medical records are not employed shared. Methods Using data collected from the Shanghai Breast Cancer Survival Study (SBCSS), a population-based, prospective cohort study of 5,042 women diagnosed with breast cancer Shanghai, China, we compared concordance patient questionnaire responses to survey administered approximately 6 months after diagnosis...