A5058650746- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- BRCA gene mutations in cancer
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Vector-borne infectious diseases
- Renal cell carcinoma treatment
- Kidney Stones and Urolithiasis Treatments
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Nutritional Studies and Diet
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Metabolomics and Mass Spectrometry Studies
- Folate and B Vitamins Research
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Bioinformatics and Genomic Networks
- Liver Disease Diagnosis and Treatment
- Renal and related cancers
Memorial Sloan Kettering Cancer Center
2020-2025
Huazhong Agricultural University
2020-2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2021-2024
Kettering University
2024
The University of Texas MD Anderson Cancer Center
2012-2023
Vanderbilt University
2010-2022
University of Wisconsin–Madison
2022
Vanderbilt University Medical Center
2011-2022
Wuhan University
2019
Second Affiliated Hospital of Shantou University Medical College
2019
Abstract It remains elusive whether some of the associations identified in genome-wide association studies prostate cancer (PrCa) may be due to regulatory effects genetic variants on CpG sites, which further influence expression PrCa target genes. To search for sites associated with risk, here we establish models predict methylation (N = 1,595) and conduct analyses risk (79,194 cases 61,112 controls). We identify 759 showing an association, including 15 located at novel loci. Among those 42...
<h3>Importance</h3> Survival differences between male and female patients with breast cancer have been reported, but the underlying factors associated disparity not fully studied. This understanding is fundamental to developing strategies for treatment survivorship care. <h3>Objective</h3> To compare mortality quantitatively evaluate sex-based in mortality. <h3>Design, Setting, Participants</h3> large, nationwide, registry-based cohort study used National Cancer Database identify obtain data...
Abstract Background In addition to the established association between general obesity and breast cancer risk, central circulating fasting insulin glucose have been linked development of this common malignancy. Findings from previous studies, however, inconsistent, nature associations is unclear. Methods We conducted Mendelian randomization analyses evaluate using genetic instruments, with insulin, glucose, 2-h body mass index (BMI) BMI-adjusted waist-hip-ratio (WHRadj BMI). first confirmed...
Many risk factors have been identified for breast cancer. The potential causality some of them remains uncertain, and few studies comprehensively investigated these associations by molecular subtypes. We performed a two-sample Mendelian randomization (MR) study to evaluate causal 23 known suspected biomarkers with cancer overall subtypes using data from the Breast Cancer Association Consortium. inverse-variance weighted method was used estimate odds ratios (OR) 95% confidence interval (CI)...
Non-European populations are under-represented in genetics studies, hindering clinical implementation of breast cancer polygenic risk scores (PRSs). We aimed to develop PRSs using the largest available studies Asian ancestry and assess transferability PRS across ethnic subgroups.
Methionine, folate, vitamin B6, B12, niacin, and riboflavin intakes may be related to breast carcinogenesis. These associations vary by cancer type. Using the prospective cohort Shanghai Women's Health Study (1997–2008) including 718 Chinese cases, authors evaluated baseline dietary intake of these factors risk whether varied menopausal status estrogen receptor (ER) progesterone (PR) status. They estimated using hazard ratios 95% confidence intervals from Cox proportional hazards regression...
DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, role epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and data white blood cells from Framingham Heart Study (
Few prospective studies, and none in Asians, have systematically evaluated the relationship between blood metabolites colorectal cancer risk. We conducted a nested case-control study to search for risk-associated metabolite biomarkers an Asian population using samples collected prior diagnosis. Conditional logistic regression was performed assess associations of with In this study, we included 250 incident cases individually matched controls within two Shanghai cohorts. found 35 associated...
Abstract Background DNA methylation plays a critical role in breast cancer development. Previous studies have identified marks white blood cells as promising biomarkers for cancer. However, these were limited by low statistical power and potential biases. Using new methodology, we investigated their associations with risk. Methods Statistical models built to predict levels of using genetic data from HumanMethylation450 BeadChip the Framingham Heart Study (n = 1595). The prediction validated...
The association between metformin use and risk of prostate cancer remains controversial, while data from randomized trials is lacking. We aim to evaluate the genetically proxied effects with using a drug-target Mendelian randomization (MR) approach. Summary statistics for were obtained Prostate Cancer Association Group Investigate Associated Alterations in Genome Consortium (79,148 cases 61,106 controls). Cis-expression quantitative trait loci (cis-eQTL) variants gene targets identified GTEx...
Cigarette smoking is irrefutably the strongest risk factor for lung cancer; however, approximately 25% of cases worldwide occur among nonsmokers. The age-adjusted annual incidence rate cancer in Shanghai, a region where relatively few women smoke cigarettes, one highest world. To help further elucidate etiology nonsmokers, authors examined hormonal factors who were lifetime They analyzed data from prospective Shanghai Women's Health Study, which recruited Chinese aged 40-70 years between...
The authors evaluated the effect of regular exercise during first 36 months after cancer diagnosis on quality life (QOL) in a population-based cohort study 1,829 Chinese women diagnosed with breast cancer. were identified between 2002 and 2004 invited to participate about 6 diagnosis. Exercise was assessed approximately 6, 18, diagnosis, metabolic equivalent task (MET) score hours per week derived. A cumulative, weighted exercise-MET created for 36-month postdiagnosis period. QOL at...
Gastric Cancer is one of the most lethal malignancies worldwide. Gamma-glutamyl transpeptidase (GGT) an enzyme mainly involved in cellular glutathione homeostasis. We aim to explore clinical value GGT gastric cancer.Among 322 patients enrolled, 65/82 were determined as positive serum/tumor, respectively. High tumor expression significantly associated with lymph node metastasis, histological subtype, and Her2 expression. Kaplan-Meier curve shows that high have shorter overall survival (P...
In contrast to the consistent evidence for obesity and colorectal cancer (CRC) risk, impact of in CRC patients is less clear. a well-characterised cohort patients, we prospectively evaluated class I II with survival outcomes.The (N=634) were followed from date diagnosis until disease progression/first recurrence (progression-free (PFS)) or death (overall (OS)). Body mass index (BMI) was calculated reported usual weight prior diagnosis. Hazard ratios (HRs) 95% confidence intervals (CIs)...
Using a metabolomics approach, we systematically searched for circulating metabolite biomarkers pancreatic cancer risk in case-control study nested within two prospective Shanghai cohorts. Included our were 226 incident cases and their individually-matched controls. Untargeted mass spectrometry platforms used to measure metabolites blood samples collected prior diagnosis. Conditional logistic regression was performed assess the associations of with risk. We identified 10 associated cancer,...
Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 patients. Paired t-test was used tumour–normal comparisons and Cox regression model performed compute hazard ratios (HRs) corresponding 95% CIs. A 17-miRNA signature that can concordantly classify >95% of tumour/adjacent normal samples. Significant...
Epidemiological evidence on the association between tea consumption and risk of type 2 diabetes (T2D) is inconsistent. This study prospectively investigated whether green drinking affects T2D.
Stanniocalcin 2 (STC2) is a glycoprotein hormone involved in many biological processes and secretory protein that regulates malignant tumor progression. The aim of the present study was to further explore clinicopathological significance prognostic role STC2 colorectal cancer (CRC).In this study, expression first investigated Gene Expression Omnibus Cancer Genome Atlas, then validated with data from our medical center. Univariate multivariate analyses were performed assess association...
Abstract Colonization of specific bacteria in the human mouth was reported to be associated with gastric cancer risk. However, previous studies were limited by retrospective study designs and low taxonomic resolutions. We performed a prospective case‐control nested within three cohorts investigate relationship between oral microbiome Shotgun metagenomic sequencing employed characterize prediagnostic buccal samples from 165 cases 323 matched controls. Associations overall microbial richness...
<h3>Importance</h3> Polygenic risk scores (PRSs) have shown promise in breast cancer prediction; however, limited studies been conducted among Asian women. <h3>Objective</h3> To develop prediction models for women incorporating PRSs and nongenetic factors. <h3>Design, Setting, Participants</h3> This diagnostic study included of ancestry from the Asia Breast Cancer Consortium. were developed using data genomewide association (GWASs) 123 041 with (including 18 650 cancer) 3 approaches: (1)...
Moderate-intensity exercise has attracted considerable attention because of its safety and many health benefits. Tai Chi, a form mind-body that originated in ancient China, been gaining popularity. Practicing Chi may improve overall well-being; however, to our knowledge, no study evaluated relationship with mortality. We assessed the associations regular specifically participation walking, jogging total cause-specific mortality among 61,477 Chinese men Shanghai Men's Health Study...