A5046759596- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Economic and Financial Impacts of Cancer
- Cancer Risks and Factors
- Genetic Associations and Epidemiology
- Cancer survivorship and care
- Cervical Cancer and HPV Research
- Genetic factors in colorectal cancer
- Estrogen and related hormone effects
- Genomic variations and chromosomal abnormalities
- Health Systems, Economic Evaluations, Quality of Life
- HER2/EGFR in Cancer Research
- AI in cancer detection
- Nutrition, Genetics, and Disease
- Cancer and Skin Lesions
- Breast Implant and Reconstruction
- DNA Repair Mechanisms
- Cancer Immunotherapy and Biomarkers
- Family Support in Illness
- Global Health and Surgery
- Monoclonal and Polyclonal Antibodies Research
University of Malaya
2016-2025
Subang Jaya Medical Centre
2016-2025
University Malaya Medical Centre
2012-2024
East Lancashire Hospitals NHS Trust
2023-2024
Cancer Research Malaysia
2016-2023
Hospital Kuala Lumpur
1988-2023
National Cancer Council Malaysia
2023
Sarawak General Hospital
2023
University of Wisconsin–Madison
2022
University of Auckland
2020
Breast cancer outcomes in low- and middle-income countries (LMCs) correlate with the degree to which 1) cancers are detected at early stages, 2) newly can be diagnosed correctly, 3) appropriately selected multimodality treatment provided properly a timely fashion. The Health Global Initiative (BHGI) invited international experts review revise previously developed BHGI resource-stratified guideline tables for detection, diagnosis, treatment, healthcare systems. Focus groups addressed specific...
When breast cancer is detected and treated early, the chances of survival are very high. However, women in many settings face complex barriers to early detection, including social, economic, geographic, other interrelated factors, which can limit their access timely, affordable, effective health care services. Previously, Breast Health Global Initiative (BHGI) developed resource‐stratified guidelines for detection diagnosis cancer. In this consensus article from sixth BHGI Summit held...
To provide an overview of the incidence and mortality female breast cancer for countries in Asia-Pacific region.
Abstract: Breast cancer is the most common cause of cancer-related death among women worldwide, with case fatality rates highest in low-resource countries. Despite significant scientific advances its management, world faces resource constraints that limit capacity to improve early detection, diagnosis, and treatment disease. The Health Global Initiative (BHGI) strives develop evidence-based, economically feasible, culturally appropriate guidelines can be used nations limited health care...
PURPOSE To estimate age-specific relative and absolute cancer risks of breast to ovarian, pancreatic, male breast, prostate, colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these have not been extensively characterized. METHODS We analyzed data from 524 families PVs 21 countries. Complex segregation analysis was used (RRs; country-specific population incidences) cancers. The models allowed for residual familial aggregation ovarian were adjusted the...
Abstract A key determinant of breast cancer outcome in any population is the degree to which cancers are detected at early stages disease. Populations earlier have lower mortality rates. The Breast Health Global Initiative (BHGI) held its third Summit Budapest, Hungary October 2007, bringing together internationally recognized experts address implementation healthcare guidelines for detection, diagnosis, and treatment low- middle-income countries (LMCs). multidisciplinary panel specifically...
A major challenge in value-based health care is the lack of standardized outcomes measurements, hindering optimal monitoring and comparison quality across different settings globally. The International Consortium for Health Outcomes Measurement (ICHOM) assembled a multidisciplinary international working group, comprised 26 providers patient advocates, to develop standard set patient-centered breast cancer (BC). group convened via 8 teleconferences completed follow-up survey after each...
Rare germline genetic variants in several genes are associated with increased breast cancer (BC) risk, but their precise contributions to different disease subtypes unclear. This information is relevant guidelines for gene panel testing and risk prediction.To characterize tumors BC susceptibility large-scale population- or hospital-based studies.The multicenter, international case-control analysis of the BRIDGES study included 42 680 patients 46 387 control participants, comprising women...
Abstract: As the largest cancer killer of women around globe, breast adversely impacts countries at all levels economic development. Despite major advances in early detection, diagnosis, and treatment cancer, health care ministries face multitiered challenges to create support programs that can improve outcomes. In addition financial organizational problems inherent any system, are hindered by a lack recognition as public priority, trained personnel shortages migration, provider educational...
Two hospital-based breast cancer databases (University Malaya Medical Center, Malaysia [n = 1513] and National University Hospital, Singapore 2545]) were merged into a regional registry of patients diagnosed between 1990 2007. A review the data found 51% before age 50 years. 72% percent women Chinese followed by Malays (16%), Indians (8%), other races (4%). Median tumor size at presentation was 26 mm about 25% presented with TNM stage III or IV disease. Most tumors ductal histology (87%)....
Polygenic risk scores (PRS) have been shown to predict breast cancer in European women, but their utility Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry using data from 17,262 cases and 17,695 controls of ancestry 13 case-control studies, 10,255 Chinese a prospective cohort (413 incident cancers). Compared middle quintile distribution, highest 1% PRS distribution ~2.7-fold lowest has ~0.4-fold developing cancer. There no evidence heterogeneity...
Background The Breast Health Global Initiative (BHGI) established a series of resource‐stratified, evidence‐based guidelines to address breast cancer control in the context available resources. Here, authors describe methodologies and health system prerequisites support translation implementation these into practice. Methods In October 2018, BHGI convened Sixth Summit on Improving Healthcare Through Resource‐Stratified Phased Implementation. purpose summit was define stepwise methodology (...
Background Breast cancer risk factors have been examined extensively in Western setting and more developed Asian cities/countries. However, there are limited data on developing countries. The purpose of this study was to examine breast the change selected across birth cohorts Malaysian women. Methods An unmatched hospital based case-control conducted from October 2002 December 2016 Selangor, Malaysia. A total 3,683 cases 3,980 controls were included study. Unconditional logistic regressions,...
Abstract Molecular profiling of breast cancer has enabled the development more robust molecular prognostic signatures and therapeutic options for patients. However, non-Caucasian populations remain understudied. Here, we present mutational, transcriptional, copy number profiles 560 Malaysian tumours a comparative analysis cancers arising in Asian Caucasian women. Compared to women, show an increased prevalence HER2-enriched subtypes higher TP53 somatic mutations ER+ tumours. We also observe...