A5064150548- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Optical Coherence Tomography Applications
- Cancer Risks and Factors
- Photoacoustic and Ultrasonic Imaging
- Cancer survivorship and care
- Ultrasound Imaging and Elastography
- BRCA gene mutations in cancer
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Palliative Care and End-of-Life Issues
- Advances in Oncology and Radiotherapy
- Childhood Cancer Survivors' Quality of Life
- Economic and Financial Impacts of Cancer
- Estrogen and related hormone effects
- Family Support in Illness
- Advanced Radiotherapy Techniques
- Digital Radiography and Breast Imaging
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- Infrared Thermography in Medicine
- Optical Imaging and Spectroscopy Techniques
- Menopause: Health Impacts and Treatments
- Lymphatic System and Diseases
- Patient-Provider Communication in Healthcare
The University of Melbourne
2015-2025
The University of Western Australia
2015-2024
Fiona Stanley Hospital
2016-2024
The Royal Melbourne Hospital
2022-2024
St John of God Subiaco Hospital
2014-2024
Peter MacCallum Cancer Centre
2021-2024
Royal Perth Hospital
2014-2023
St John of God Hospital
2015-2022
International Breast Cancer Study Group
2021
Queen Elizabeth II Medical Centre
2005-2019
Background Aromatase inhibitors eff ectively prevent breast cancer recurrence and development of new contralateral tumours in postmenopausal women.We assessed the effi cacy safety aromatase inhibitor anastrozole for prevention women who are at high risk disease.Methods Between Feb 2, 2003, Jan 31, 2012, we recruited aged 40-70 years from 18 countries into an international, double-blind, randomised placebo-controlled trial.To be eligible, had to increased (judged on basis specifi c...
Abstract Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early cancer. Design Prospective, open label, randomised controlled clinical trial. Setting 32 centres in 10 countries the United Kingdom, Europe, Australia, States, and Canada. Participants 2298 women aged 45 years older with invasive ductal carcinoma up to 3.5 cm size, cN0-N1,...
Probing the mechanical properties of tissue on microscale could aid in identification diseased tissues that are inadequately detected using palpation or current clinical imaging modalities, with potential to guide medical procedures such as excision breast tumours. Compression optical coherence elastography (OCE) maps strain spatial resolution and can delineate microstructural features within tissues. However, without a measure locally applied stress, provides only qualitative indication...
A major challenge in value-based health care is the lack of standardized outcomes measurements, hindering optimal monitoring and comparison quality across different settings globally. The International Consortium for Health Outcomes Measurement (ICHOM) assembled a multidisciplinary international working group, comprised 26 providers patient advocates, to develop standard set patient-centered breast cancer (BC). group convened via 8 teleconferences completed follow-up survey after each...
Prospective data on the risk of recurrence among women with hormone receptor–positive early breast cancer who temporarily discontinue endocrine therapy to attempt pregnancy are lacking. Download a PDF Research Summary. We conducted single-group trial in which we evaluated temporary interruption adjuvant young previous cancer. Eligible were 42 years age or younger; had stage I, II, III disease; received for 18 30 months; and desired pregnancy. The primary end point was number events (defined...
The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use novel optical systems and techniques for improved health care biomedical research.
<b>Objectives</b> To identify women who survived breast cancer and subsequently conceived to determine the rate of pregnancy (proportion), management, outcome cancer, first subsequent pregnancy. <b>Design</b> Population based descriptive study with cases identified from Western Australian data linkage system validated by review medical charts. Supplementary obtained hospital clinician records. <b>Setting</b> Australia, 1982-2003. <b>Participants</b> Women aged <45 a diagnosis conceived....
We sought biomarkers of breast cancer in the breath because disease is accompanied by increased oxidative stress and induction cytochrome P450 enzymes, both which generate volatile organic compounds (VOCs) that are excreted breath. analyzed VOCs 54 women with biopsy-proven 204 cancer-free controls, using gas chromatography/mass spectroscopy. Chromatograms were converted into a series data points segmenting them 900 time slices (8 s duration, 4 overlap) determining their alveolar gradients...
Fertility is a priority for many young women with breast cancer. Women need to be informed about interventions retain fertility before chemotherapy so as make good quality decisions. This study aimed prospectively evaluate the efficacy of fertility-related decision aid (DA). A total 120 newly diagnosed early-stage cancer patients from 19 Australian oncology clinics, aged 18–40 years and desired future fertility, were assessed on decisional conflict, knowledge, regret, satisfaction treatment...
We present optical coherence micro-elastography, an improved form of compression elastography. demonstrate the capacity this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. use phase-sensitive, three-dimensional tomography (OCT) probe nanometer-to-micrometer-scale axial displacements tissues induced by compressive loading. Optical micro-elastography incorporates common-path...
Abstract An accurate intraoperative identification of malignant tissue is a challenge in the surgical management breast cancer. Imaging techniques that help address this could contribute to more complete and tumor excision, thereby reduce current high reexcision rates without resorting removal excess healthy tissue. Optical coherence microelastography (OCME) three-dimensional, high-resolution imaging technique sensitive microscale variations mechanical properties As modifies tissue, OCME has...
Young patients with breast cancer (BC) are often concerned about treatment-induced infertility and express maternity desire. Conception after BC does not seem to affect outcome, but information in estrogen-receptor positive (ER+) disease is definitive. From September 2012-March 2013, 212 evaluable ER+ early BC, <37 years at diagnosis, from 5 regions (Europe/US/Canada/Middle-East/Australia) answered a survey fertility concerns, desire interest study of endocrine therapy (ET) interruption...
Abstract Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable marks associated with breast by studying 25 Australian multiple-case families. Here we report genome-wide measured 210 peripheral blood samples provided family members using Infinium HumanMethylation450. develop and apply a new statistical method identify based on complex segregation analysis. estimate carrier probabilities...
Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 -30% cases requiring second surgical procedure arising from postoperative detection an involved margin.We report advances the development new intraoperative tool, optical coherence micro-elastography, for assessment tumor margins on micro-scale.We demonstrate important step by conducting whole specimen imaging time frames wide-field scanning system acquiring mosaicked elastograms overall...
<h3>Importance</h3> Conventional adjuvant radiotherapy for breast cancer given daily several weeks is onerous and expensive. Some patients may be obliged to choose a mastectomy instead, some forgo altogether. We proposed clinical trial test whether could safely limited the tumor bed. <h3>Objective</h3> To determine delayed second-procedure targeted intraoperative (TARGIT-IORT) noninferior whole-breast external beam (EBRT) in terms of local control. <h3>Design, Setting, Participants</h3> In...
Abstract Inadequate margins in breast-conserving surgery (BCS) are associated with an increased likelihood of local recurrence breast cancer. Currently, approximately 20% BCS patients require repeat due to inadequate at the initial operation. Implementation accurate, intraoperative margin assessment tool may reduce this re-excision rate. This study determined, for first time, diagnostic accuracy quantitative micro-elastography (QME), optical coherence tomography (OCT)–based elastography...