A5043244249- Chronic Disease Management Strategies
- Cancer survivorship and care
- Primary Care and Health Outcomes
- Diabetes Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Metabolism, Diabetes, and Cancer
- BRCA gene mutations in cancer
- Palliative Care and End-of-Life Issues
- Cancer Genomics and Diagnostics
- Heart Failure Treatment and Management
- Family Support in Illness
- Health Systems, Economic Evaluations, Quality of Life
- Organ Transplantation Techniques and Outcomes
- Medical Coding and Health Information
- Organ Donation and Transplantation
- Healthcare Policy and Management
- Electrolyte and hormonal disorders
- Chronic Kidney Disease and Diabetes
- Mental Health Treatment and Access
- Peroxisome Proliferator-Activated Receptors
- Cancer-related cognitive impairment studies
- Healthcare Systems and Technology
- Cancer Risks and Factors
- Blood Pressure and Hypertension Studies
Clinical Practice Research Datalink
2016-2025
Mercer University
2024
St Vincent's Hospital Sydney
2007-2023
South Western Sydney Local Health District
2020-2022
University of Liverpool
2022
Peter MacCallum Cancer Centre
2021
University of Wolverhampton
2021
Massachusetts General Hospital
2017-2020
Sydney Local Health District
2020
Hull York Medical School
2019
Abstract Background People with intellectual disabilities (IDs) die at younger ages than the general population, but nationally representative and internationally comparable mortality data about people ID, quantifying extent pattern of excess, have not previously been reported for England. Method We used from Clinical Practice Research Datalink database April 2010 to March 2014 (CPRD GOLD September 2015). This source covered several hundred participating practices comprising roughly 5%...
Abstract A prospective validation study was conducted in 171 consenting patients from oncology and palliative care outpatient clinics to validate the Distress Thermometer (DT) against Hospital Anxiety Depression Scale (HADS), General Health Questionnaire‐12 (GHQ‐12) Brief Symptom Inventory‐18 (BSI‐18) at baseline, four weeks eight weeks. Receiver Operating Characteristic analysis used examine sensitivity specificity of DT scores clinically significant cut‐off criterion measures reporting 95%...
Record linkage is increasingly used to expand the information available for public health research. An understanding of record methods and relevant strengths limitations important robust analysis interpretation linked data. Here, we describe approach by Clinical Practice Research Datalink (CPRD) link primary care data other patient level datasets, potential implications this CPRD analysis. General practice electronic software providers separately submit de-identified identifiers NHS Digital,...
Abstract Background We evaluated the risk of pelvic inflammatory disease (PID), ectopic pregnancy, and infertility in women with a previous Chlamydia trachomatis (CT) diagnosis compared who tested negative for CT untested women, considering both targeted incidental (ie, prescribed another indication) use CT-effective antibiotics. Methods This was retrospective study aged 12–25 years at start follow-up within Clinical Practice Research Datalink GOLD database linked to index multiple...
Abstract Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable marks associated with breast by studying 25 Australian multiple-case families. Here we report genome-wide measured 210 peripheral blood samples provided family members using Infinium HumanMethylation450. develop and apply a new statistical method identify based on complex segregation analysis. estimate carrier probabilities...
Primary care databases are increasingly used for researching pregnancy, eg, the effects of maternal drug exposures. However, ascertaining pregnancies, their timing, and outcomes in these data is challenging. While individual studies have adopted different methods, no systematic approach to characterise all pregnancies a primary database has yet been published. Therefore, we developed new algorithm establish Pregnancy Register UK Clinical Practice Research Datalink (CPRD) GOLD database.We...
There is limited high-quality evidence on quality of life, anxiety, and depressive symptoms in breast cancer survivors women with no history cancer. We aimed to address this by comparing patient-reported outcomes between cancer.Breast prior were selected from the UK Clinical Practice Research Datalink GOLD primary care database, which includes population-based electronic health record data. Breast controls frequency matched age practice. Outcomes assessed validated instruments via postal...
Background Breast cancer is the most common diagnosed in women globally, and 5-year net survival probabilities high-income countries are generally >80%. A diagnosis treatment often traumatic events, many struggle to cope during this period. Less known, however, about long-term mental health impact of disease, despite living several years beyond their breast being a major source disability modern societies. The objective study was quantify risk adverse health–related outcomes with history...
ABSTRACT Purpose Maternal exposures before, during and after pregnancy can affect the infant. It is therefore important that researchers study mothers their children. The CPRD GOLD Mother–Baby Link (MBL) algorithm was applied to Aurum database, extend useful tool. Here, we present data resource profiles of MBLs. Methods Records female patients registered with a practice between 1st January 1987 June 2023 were searched for evidence delivery. Infants born matched on household indicators....
LMO4 belongs to a family of LIM-only transcriptional regulators, the first two members which are oncoproteins in acute T cell leukemia. We have explored role for LMO4, initially described as human breast tumor autoantigen, developing mammary epithelium and oncogenesis. Lmo4 was expressed predominantly lobuloalveoli gland during pregnancy. Consistent with proliferation, forced expression this gene inhibited differentiation epithelial cells. Overexpression mRNA observed 5 10 cancer lines....
<b>Objective</b> To evaluate the association between pioglitazone use and bladder cancer risk in patients with type 2 diabetes. <b>Design</b> Retrospective cohort study using propensity score matched cohorts. <b>Settings</b> Healthcare databases from Finland, Netherlands, Sweden, United Kingdom. Data comprised country specific datasets of linked records on prescriptions, hospitals, general practitioners, cancer, deaths. <b>Participants</b> Patients diabetes who initiated...
Objective To assess the effect of coding quality on estimates incidence diabetes in UK between 1995 and 2014. Design A cross-sectional analysis examining from to 2014 how choice codes (diagnosis vs which suggest diagnosis) affect estimated incidence. Setting Routine primary care data 684 practices contributing Clinical Practice Research Datalink (data contributed Vision (INPS) practices). Main outcome measure Incidence rates they are affected by (1) GP (2) excluding ‘poor’ with at least 10%...
There is a lack of validated instruments measuring perceived stigma in people with intellectual disability.To develop valid and reliable self-rated instrument to measure that can be completed by mild moderate disability.A literature search was used generate list statements. Professionals, individuals disability carers were consulted about the suitability An developed containing statements accompanying photographs. Test-retest reliability, internal consistency factor structure evaluated.The...
To investigate whether continuity of care in family practice reduces unplanned hospital use for people with serious mental illness (SMI).Linked administrative data on and utilization by SMI England, 2007-2014.This observational cohort study used discrete-time survival analysis to the relationship between use: emergency department (ED) presentations, admissions ambulatory care-sensitive conditions (ACSC). The distinguishes relational management/ informational (as captured plans) accounts...
To investigate why episodes of pregnancy identified from electronic health records may be incomplete or conflicting (overlapping), and provide guidance on how to handle them.Pregnancy Register generated the Clinical Practice Research Datalink (CPRD) GOLD UK primary care database.Female patients with at least one episode in (01 January 1937-31 December 2017) which had no recorded outcome conflicted another episode.We multiple scenarios potentially explaining uncertain occur. Criteria were...
Objectives To describe the benefits and limitations of using individual combinations linked English electronic health data to identify incident cancers. Design setting Our descriptive study uses Clinical Practice Research Datalink primary care; cancer registration; hospitalisation death registration data. Participants measures We implemented case definitions first site-specific cancers at 20 most common sites, based on ever diagnosis recorded in each or commonly used combination sources...
Abstract Aims To assess real‐world use of Saxenda® (liraglutide 3.0 mg) and off‐label Victoza® 1.2 mg/1.8 for weight management posology in the United Kingdom. Their similar doses formulation pose a risk inadvertent due to their different indications. Materials Methods This retrospective, non‐interventional drug utilization cohort study (DUS), based on anonymized patient data from Clinical Practice Research Datalink databases (CPRD Aurum, GOLD), included adult liraglutide initiators without...