A5049764777- Reproductive tract infections research
- Reproductive Health and Contraception
- Urinary Tract Infections Management
- Adolescent Sexual and Reproductive Health
- HIV, TB, and STIs Epidemiology
- Pelvic floor disorders treatments
- Blood groups and transfusion
- Urinary and Genital Oncology Studies
- European Law and Migration
- Immune Response and Inflammation
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Dutch Social and Cultural Studies
- Genital Health and Disease
- Bacterial Identification and Susceptibility Testing
- Syphilis Diagnosis and Treatment
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
- HIV Research and Treatment
National Institute for Public Health and the Environment
2017-2024
Maastricht University
2024
Institute of Public Health Zadar
2021
Office of Public Health Genomics
2021
Centro de Genética Clínica
2021
Celulose Beira Industrial (Portugal)
2021
Perinatal Institute
2021
National Centre for Infectious Diseases
2021
Maastricht University Medical Centre
2021
Amsterdam University Medical Centers
2021
Abstract Background We evaluated the risk of pelvic inflammatory disease (PID), ectopic pregnancy, and infertility in women with a previous Chlamydia trachomatis (CT) diagnosis compared who tested negative for CT untested women, considering both targeted incidental (ie, prescribed another indication) use CT-effective antibiotics. Methods This was retrospective study aged 12–25 years at start follow-up within Clinical Practice Research Datalink GOLD database linked to index multiple...
Objectives A better understanding of Chlamydia trachomatis infection (chlamydia)–related sequelae can provide a framework for effective chlamydia control strategies. The objective this study was to estimate risks and risk factors pelvic inflammatory disease (PID), ectopic pregnancy tubal factor infertility (TFI) with follow-up time up until 8 years in women previously tested the Screening Implementation (CSI) participating Netherlands Cohort Study (NECCST). Methods Women who participated CSI...
Abstract Background. After the scale-up of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection in Africa, increasing numbers patients have pretreatment drug resistance. Methods. In a large multicountry cohort starting standard first-line ART six African countries, pol genotyping was retrospectively performed if viral load (VL) ≥1000 cps/mL. Pretreatment resistance defined as decreased susceptibility to ≥1 prescribed drug. We assessed effect on all-cause mortality,...
The clinical and public health relevance of widespread testing for asymptomatic
Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection (STI) among young women, can result in serious sequelae. Although course of is often asymptomatic, CT may cause pelvic inflammatory disease (PID), leading to severe complications, such as prolonged time pregnancy, ectopic and tubal factor subfertility. The risk factors for complications following CT-infection have not been assessed a long-term prospective cohort study, preferred design define infections...
Background A Chlamydia trachomatis infection (chlamydia) can result in tubal factor infertility women. To assess if this association results fewer pregnant women, we aimed to pregnancy incidences and time among women with a previous chlamydia compared without one who were participating the Netherlands Cohort Study (NECCST). Methods The NECCST is cohort of reproductive age tested for screening trial between 2008 2011 reinvited 2015 2016. status (positive/negative) was defined using...
Chlamydia trachomatis (Ct) whole-proteome microarrays were utilized to identify antibody patterns associated with infection; pelvic inflammatory disease (PID), tubal factor infertility, chronic pain (CPP) and ectopic pregnancy in a subsample of the Netherlands cohort study. Serum pools analyzed on arrays. The 121 most reactive antigens identified during arrays selected for further analysis minimized that allowed single sera analysis. From 232 sera; 145 (62.5%) serum samples at least one...
Capillary blood collected in serum tubes was subjected to centrifugation delay while stored at room temperature. Chlamydia trachomatis (CT) IgG concentrations aliquoted of these samples remained stable for seven days after collection. CT can reliably be measured mailed epidemiological studies.
To report sex and age-specific
The asymptomatic course of Chlamydia trachomatis (CT) infections can result in underestimated CT lifetime prevalence. Antibody testing might improve this estimate. We assessed antibody positivity and predictive factors thereof the Netherlands Cohort Study. Women who had ≥1 Nucleic Acid Amplification Test (NAAT) study (2008-2011) provided self-reported information on NAATs were tested for major outer membrane protein specific IgG serum (2016). was identified using multivariable logistic...
Clear inter-individual differences exist in the response to C. trachomatis (CT) infections and reproductive tract complications women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with CT infection, SNPs might be used as a component tubal-pathology predicting algorithm. Our aim was confirm role of four genes by investigating proven susceptibility severity infection. A total 1201 women from five cohorts were genotyped analyzed for TLR2 + 2477 G >...
Background: The clinical and public health relevance of widespread testing for asymptomatic Chlamydia trachomatis (chlamydia) infections is under debate. To address uncertainties in screening program effectiveness, we estimate reproductive tract complication risks following undiagnosed, asymptomatic, symptomatic chlamydia a long-term observational cohort. Methods: A cohort 5704 reproductive-age women recruited from study was followed up to 14 years. status determined using NAAT results,...
<h3>Background</h3> Studies have shown an association between <i>Chlamydia trachomatis</i> infection (chlamydia) and increased risk for tubal factor infertility (TFI) in women. To assess if this also result fewer pregnancies, we aimed to investigate the proportion of pregnancies women with without a previous chlamydia participating Netherlands Chlamydia Cohort Study (NECCST). <h3>Methods</h3> NECCST is cohort 5704 reproductive age all tested by PCR screening study 2008–11. Women were...
<h3>Background</h3> Chlamydia trachomatis infections can cause reproductive tract problems, but it remains unclear to what extent past are associated with outcomes such as miscarriages, preterm birth and stillbirth. We assessed these in women without a previous chlamydia infection participating the Netherlands Cohort Study (NECCST). <h3>Methods</h3> NECCST is cohort of 5,704 age all tested for by PCR screening study between 2008–11. Women were re-invited 2015–16. Chlamydia-status...