A5029087093- Reproductive tract infections research
- Reproductive System and Pregnancy
- Gynecological conditions and treatments
- Reproductive Physiology in Livestock
- Bacterial Identification and Susceptibility Testing
- Immune Response and Inflammation
- Urinary Tract Infections Management
- Blood groups and transfusion
- Sexual function and dysfunction studies
- Pelvic floor disorders treatments
- Syphilis Diagnosis and Treatment
Amsterdam UMC Location Vrije Universiteit Amsterdam
2015-2019
Chlamydia trachomatis (Ct) is the leading cause of bacterial sexually transmitted diseases (STD) worldwide. The Ct Multi Locus Sequence Typing (MLST) scheme effective in differentiating strain types (ST), deciphering transmission patterns and treatment failure, identifying recombinant strains. Here, we analyzed 323 reference clinical samples, including 58 samples from Russia, an area that has not previously been represented typing schemes, to expand our knowledge global diversification STs....
Intracellular pattern-recognition receptors NOD1 and NOD2 are capable of sensing common structural units bacterial walls. Recognition triggers specific immune signalling pathways leads to pro-inflammatory cytokine upregulation adequate response. We investigated whether two functional polymorphisms in exert an effect on susceptibility (STD patients) severity (female patients visiting the fertility clinic) Chlamydia trachomatis infection 807 Dutch Caucasian women. A significant association...
Problem Tubal factor infertility (TFI) is a severe complication of genital Chlamydia trachomatis infections. In fertility workup, chlamydia antibody test (CAT) used to predict TFI. The predictive value for TFI most commonly CAT moderate. Method study A total 183 infertile Dutch Caucasian women were included in this study. All underwent tubal patency testing (hysterosalpingography [HSG] or laparoscopy). Cases had TFI, and controls no (ie normal findings during HSG was categorized based on...
Capillary blood collected in serum tubes was subjected to centrifugation delay while stored at room temperature. Chlamydia trachomatis (CT) IgG concentrations aliquoted of these samples remained stable for seven days after collection. CT can reliably be measured mailed epidemiological studies.
There is a need for more accurate Chlamydia trachomatis (CT) IgG antibody tests tubal factor infertility (TFI) diagnostics. We evaluated the predictive value TFI of Medac ELISA plus (MOMP) and multitarget Mikrogen (MOMP-CPAF-TARP). Based on results, 183 subfertile women underwent either hysterosalpingography or laparoscopy to diagnose TFI. was defined as extensive adhesions and/or distal occlusion at least one tube. Women not fulfilling definition served controls. Serum subsequently tested...
Chlamydia trachomatis (CT) IgG serology is used in many fertility clinics order to estimate the risk for tubal factor infertility (TFI) work-up. The predictive value TFI of currently mono-target CT test should be improved. This study compares performance new multi-target Mikrogen recomWell ELISA with recomLine immunoblot and visualizes distribution individual antibodies serum potentially improve current that clinically used. Study population consisted 183 Dutch Caucasian infertile women who...
Abstract STUDY QUESTION Does C-reactive protein (CRP), as a marker of persisting low-grade inflammation, identify Chlamydia trachomatis IgG antibody test (CAT)-positive women who are at the highest risk for tubal factor infertility (TFI)? SUMMARY ANSWER No association was found between slightly elevated CRP (seCRP) levels and TFI in our CAT-positive patient population. WHAT IS KNOWN ALREADY In fertility work-up, CAT is used to estimate select high-risk patients additional invasive diagnostic...