A5007945636- Transplantation: Methods and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Retinal and Optic Conditions
- Mechanical Circulatory Support Devices
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Blood transfusion and management
- Cardiac Arrest and Resuscitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Concrete and Cement Materials Research
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Cardiac Structural Anomalies and Repair
- Bariatric Surgery and Outcomes
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Corneal surgery and disorders
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Corneal Surgery and Treatments
University of Bristol
2016-2025
Tempus Labs (United States)
2024-2025
Tufts University
2003-2024
University of Southampton
2013-2024
At Bristol
2018-2024
Bristol Royal Infirmary
2014-2024
University of Wolverhampton
2024
University of Alabama at Birmingham
2022-2024
National Institute for Health Research
2013-2023
University Hospitals Bristol NHS Foundation Trust
2020-2023
Background— Red blood cell transfusion can both benefit and harm. To inform decisions about transfusion, we aimed to quantify associations of with clinical outcomes cost in patients having cardiac surgery. Methods Results— Clinical, hematology, databases were linked the UK population register. Additional hematocrit information was obtained from intensive care unit charts. Composite infection (respiratory or wound septicemia) ischemic (myocardial infarction, stroke, renal impairment, failure)...
Bevacizumab has been suggested to have similar effectiveness ranibizumab for treatment of neovascular age-related macular degeneration. The Inhibition VEGF in Age-related choroidal Neovascularisation (IVAN) trial was designed compare these drugs and different regimens. Here, we report the findings at prespecified 2-year timepoint.In a multicentre, 2×2 factorial, non-inferiority randomised trial, enrolled adults aged least 50 years with active, previously untreated degeneration best corrected...
Whether a restrictive threshold for hemoglobin level in red-cell transfusions, as compared with liberal threshold, reduces postoperative morbidity and health care costs after cardiac surgery is uncertain.We conducted multicenter, parallel-group trial which patients older than 16 years of age who were undergoing nonemergency recruited from 17 centers the United Kingdom. Patients less 9 g per deciliter randomly assigned to transfusion (hemoglobin <7.5 deciliter) or <9 deciliter). The primary...
<h3>Importance</h3> The optimal approach to airway management during out-of-hospital cardiac arrest is unknown. <h3>Objective</h3> To determine whether a supraglottic device (SGA) superior tracheal intubation (TI) as the initial advanced strategy in adults with nontraumatic arrest. <h3>Design, Setting, and Participants</h3> Multicenter, cluster randomized clinical trial of paramedics from 4 ambulance services England responding emergencies for approximately 21 million people. Patients aged...
In chronic central serous chorioretinopathy (CSCR), fluid accumulates in the subretinal space. CSCR is a common visually disabling condition that develops individuals up to 60 years of age, and there no definitive treatment. Previous research suggests mineralocorticoid receptor antagonist, eplerenone, effective for treating CSCR; however, this drug not licensed treatment patients with CSCR. We aimed evaluate whether eplerenone was superior placebo terms improving visual acuity CSCR.This...
BackgroundThere is limited randomized evidence on the comparative outcomes of early-stage lung cancer resection by video-assisted thoracoscopic surgery (VATS) versus open resection.MethodsWe conducted a parallel-group multicenter trial that recruited participants with known or suspected and randomly assigned them to VATS their lesions. The primary outcome was physical function at 5 weeks as measure recovery using European Organisation for Research Treatment Cancer core health-related quality...
Extended pleurectomy decortication for complete macroscopic resection pleural mesothelioma has never been evaluated in a randomised trial. The aim of this study was to compare outcomes after extended plus chemotherapy versus alone.
Patients with advanced heart failure have a dismal prognosis and poor quality of life. Heart transplantation provides an effective treatment for subset these patients. This article cardiologists up-to-date information about referral transplantation, the role left ventricular assist devices prior to transplant, patient selection, waiting-list management donor availability. Timing is central importance; patients should be referred before complications (eg, cardiorenal syndrome or secondary...
When initiating anti-vascular endothelial growth factor (VEGF) treatment for patients with neovascular age-related macular degeneration (nAMD), knowledge of prognostic factors is important advising and guiding treatment. We hypothesized that eyes greater fluctuation in retinal thickness over time have worse outcomes than less variation.
Background Randomised controlled trials (RCTs) are essential for evidence-based medicine and increasingly rely on front-line clinicians to recruit eligible patients. Clinicians' difficulties with negotiating equipoise is assumed undermine recruitment, although these issues have not yet been empirically investigated in the context of observable events. We aimed investigate how conveyed during RCT recruitment appointments across six RCTs, a view (i) identifying practices that supported or...
Introduction Lung cancer is a leading cause of deaths worldwide and surgery remains the main treatment for early stage disease. Prior to introduction video-assisted thoracoscopic (VATS), lung resection was undertaken through an open thoracotomy. To date, evidence base supporting different surgical approaches based on non-randomised studies, small randomised trials focused mainly short-term in-hospital outcomes. Methods analysis The VIdeo assisted lobectomy versus conventional Open LobEcTomy...
Introduction Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and platinum drug the only licensed standard of care. As median survival for patients mesothelioma is 12.1 months, surgery an important consideration to improve and/or quality life. Currently, two surgical trials have been performed which found that neither extensive (extra-pleural pneumonectomy) or limited (partial pleurectomy) improved (although there was some evidence life). Therefore, clinicians...
Lung cancer is the leading cause of death. Surgery remains main method managing early-stage disease. Minimal-access video-assisted thoracoscopic surgery results in less tissue trauma than open surgery; however, it not known if improves patient outcomes.
Introduction The trial hypothesized that minimally invasive extra-corporeal circulation (MiECC) reduces the risk of serious adverse events (SAEs) after cardiac surgery operations requiring without circulatory arrest. Methods This is a multicentre, international randomized controlled across fourteen centres including patients aged ≥18 and <85 years undergoing elective or urgent isolated coronary artery bypass grafting (CABG), aortic valve replacement (AVR) surgery, CABG + AVR surgery....
The flow cytometric test measures the fluorescence intensity of intact red cells labelled with dye eosin-5-maleimide, which reacts covalently Lys-430 on first extracellular loop band 3 protein. In this study, from patients hereditary spherocytosis (HS), congenital dyserythropoietic anaemia type II, South-east Asian ovalocytosis and cryohydrocytosis have produced a greater degree reduction mean channel readings than those for other patient groups normal controls. predictive value membrane...
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