Rosie Harris
A5051147025- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- SARS-CoV-2 and COVID-19 Research
- Retinal Diseases and Treatments
- Occupational and environmental lung diseases
- Radiomics and Machine Learning in Medical Imaging
- Influenza Virus Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Retinal Imaging and Analysis
- Aortic aneurysm repair treatments
- COVID-19 Clinical Research Studies
- Surgical site infection prevention
- Retinal and Optic Conditions
- Health Systems, Economic Evaluations, Quality of Life
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Surgical Sutures and Adhesives
- Infectious Diseases and Mycology
- Gastric Cancer Management and Outcomes
- Bacterial Infections and Vaccines
- Esophageal Cancer Research and Treatment
- Delphi Technique in Research
- Lung Cancer Research Studies
- COVID-19 epidemiological studies
University of Bristol
2018-2024
At Bristol
2018-2022
Bristol Royal Infirmary
2020-2021
In chronic central serous chorioretinopathy (CSCR), fluid accumulates in the subretinal space. CSCR is a common visually disabling condition that develops individuals up to 60 years of age, and there no definitive treatment. Previous research suggests mineralocorticoid receptor antagonist, eplerenone, effective for treating CSCR; however, this drug not licensed treatment patients with CSCR. We aimed evaluate whether eplerenone was superior placebo terms improving visual acuity CSCR.This...
BackgroundThere is limited randomized evidence on the comparative outcomes of early-stage lung cancer resection by video-assisted thoracoscopic surgery (VATS) versus open resection.MethodsWe conducted a parallel-group multicenter trial that recruited participants with known or suspected and randomly assigned them to VATS their lesions. The primary outcome was physical function at 5 weeks as measure recovery using European Organisation for Research Treatment Cancer core health-related quality...
Extended pleurectomy decortication for complete macroscopic resection pleural mesothelioma has never been evaluated in a randomised trial. The aim of this study was to compare outcomes after extended plus chemotherapy versus alone.
Introduction Lung cancer is a leading cause of deaths worldwide and surgery remains the main treatment for early stage disease. Prior to introduction video-assisted thoracoscopic (VATS), lung resection was undertaken through an open thoracotomy. To date, evidence base supporting different surgical approaches based on non-randomised studies, small randomised trials focused mainly short-term in-hospital outcomes. Methods analysis The VIdeo assisted lobectomy versus conventional Open LobEcTomy...
Introduction Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and platinum drug the only licensed standard of care. As median survival for patients mesothelioma is 12.1 months, surgery an important consideration to improve and/or quality life. Currently, two surgical trials have been performed which found that neither extensive (extra-pleural pneumonectomy) or limited (partial pleurectomy) improved (although there was some evidence life). Therefore, clinicians...
Lung cancer is the leading cause of death. Surgery remains main method managing early-stage disease. Minimal-access video-assisted thoracoscopic surgery results in less tissue trauma than open surgery; however, it not known if improves patient outcomes.
Abstract Background Accurate assessment of surgical-site infection (SSI) is crucial for surveillance and research. Self-reporting patient measures are needed because current SSI tools limited assessing patients after leaving hospital. The Bluebelle Wound Healing Questionnaire (WHQ) was developed or observer completion; this study tested its acceptability, scale structure, reliability validity in with closed primary wounds abdominal surgery. Methods Patients completed the WHQ...
Case series and a post hoc subgroup analysis of large randomized trial have suggested potential benefit in treating ruptured abdominal aortic aneurysms (rAAAs) using endovascular aneurysm repair (EVAR) with local anaesthesia (LA) rather than general (GA). The uptake outcomes LA clinical practice remain unknown.The UK National Vascular Registry was interrogated for patients presenting rAAA managed EVAR under different modes between 1 January 2014 31 December 2016. primary outcome in-hospital...
8504 Background: Video assisted thoracoscopic surgery (VATS) is a popular access for lung cancer resection. However, there limited information from RCTs in-hospital to one-year clinical efficacy, safety and oncologic outcomes of minimal approach. Methods: VIOLET parallel group multi-center RCT conducted in 9 centers the United Kingdom that recruited participants with known or suspected (cT1-3, N0-1 M0) (ISRCTN13472721). Trial protocol: https://bmjopen.bmj.com/content/9/10/e029507.info....
Abstract Background In February 2021, the UK Department of Health and Social Care sought evidence on safety immunogenicity COVID-19 influenza vaccine co-administration to inform 2021/2022 policy. Co-administration could support uptake reduce healthcare appointments. ComFluCOV was a randomised controlled trial designed provide this evidence. This report outlines methods used deliver in 6 months answer an urgent public health question as part pandemic response. Methods commissioned by managed...
Recruiting to randomised trials is often challenging particularly when the intervention arms are markedly different. The Mesothelioma and Radical Surgery 2 controlled trial (RCT) compared standard chemotherapy with or without (extended) pleurectomy decortication surgery for malignant pleural mesothelioma. Anticipating recruitment difficulties, a QuinteT Recruitment Intervention was embedded in main phase unearth address barriers. achieved target 4-month COVID-19 pandemic-related extension....
Surgical site infection (SSI) affects up to 20% of people with a primary closed wound after surgery. Wound dressings may reduce SSI. To assess the feasibility multicentre randomised controlled trial (RCT) evaluate effectiveness and cost-effectiveness dressing types or no SSI in surgical wounds. Phase A - semistructured interviews, outcome measure development, practice survey, literature reviews value-of-information analysis. B pilot RCT qualitative research questionnaire validation. Patients...
Background In chronic central serous chorioretinopathy, fluid accumulates in the subretinal space and causes permanent vision loss ≈ 30% of patients. There is no definitive treatment. Previous research suggests that mineralocorticoid receptor antagonist eplerenone effective but it not licensed for chorioretinopathy. Objectives The objective was to evaluate whether or safe superior placebo treating We also aimed set up a biobank DNA, serum plasma samples from treatment-naive participants...
Background: Concomitant administration of COVID-19 and influenza vaccines would reduce burden on healthcare systems. We assess the safety concomitant administration. Methods: Adults in receipt a single dose ChAdOx1 or BNT162b2 were enrolled at 12 UK sites randomised 1:1 to receive either age-appropriate placebo alongside second vaccine. Three weeks later group who received vaccine, vice versa. Participants followed six weeks. The three seasonal, inactivated (trivalent, MF59C adjuvanted...
To investigate the effect of preoperative volume replacement therapy (VRT) on renal function, health outcome and time to fitness for discharge in diabetic patients undergoing coronary artery bypass grafting (CABG).In 2 parallel randomized controlled trials, were allocated VRT (1 ml/kg/h Hartmann's solution 12 h) or usual care. Primary was discharge. Secondary outcomes included acute kidney injury, postoperative complications, patient-reported quality life (QoL), hospital resource use markers...
Background: Extended pleurectomy decortication for complete macroscopic resection pleural mesothelioma has never been evaluated in a randomised trial to determine its effect on overall survival.Methods: Eligible patients were surgery and chemotherapy or alone. Primary outcome was survival secondary outcomes included disease-free survival, safety, health-related quality-of-life up 2 years.Results: 335 participants (169 chemotherapy; 166 alone). Baseline characteristics well-balanced, majority...
Controlled reoxygenation on starting cardiopulmonary bypass (CPB) rather than hyperoxic CPB may confer clinical advantages during surgery for congenital cyanotic heart disease.A single-centre, randomized controlled trial was carried out to compare the effectiveness of (normoxia) versus in children with disease undergoing open-heart (Oxic-2). The co-primary outcomes were duration inotropic support, intubation time and postoperative intensive care unit (ICU) hospital stay. Analysis primary...
Abstract Background In early 2021, the Department of Health and Social Care in UK called for research on safety immunogenicity concomitant administration COVID-19 influenza vaccines. Co-administration these vaccines would facilitate uptake reduce number healthcare visits required. The ComFluCOV trial was designed to deliver necessary evidence time inform autumn (September–November) 2021 vaccination policy. This paper presents statistical methodology applied help successfully results 6...
Surgery through a single port may be less painful because access is supplied by 1 intercostal nerve or more multiple instruments are used in port. We analyzed data collected from the video-assisted thoracoscopic surgery group of randomized controlled trial to compare differences pain up year.